日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection

TMPRSS2抑制剂对SARS-CoV-2（JN.1）和甲型流感（H1N1）病毒具有广谱疗效，并能保护小鼠免受甲型流感病毒感染。

期刊:Emerging Microbes & Infections
影响因子:7.5
doi:10.1080/22221751.2026.2616944
Presley, Lianne; Pérez-Vargas, Jimena; Saintigny, Anaïs; Villanueva, Iván; Ho, Michelle; Fone, Jessica; Brinsden, Lara; Kaushik, Nidhi; Olver, Syan; Thompson, Connor A H; Bautista-Sánchez, Diana; Ennis, Siobhan; Chen, Mike; McCallum, Matthew; Brown, Jack T; Ferková, Sára; Hetrick, Brian; Veesler, David; Leduc, Richard; Niikura, Masahiro; Boudreault, Pierre-Luc; Warner, Bryce; Jean, François
炎症/感染
流感
SARS-CoV-2
微生物学
发表日期：2026
文献求助 收藏

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting

通过C端肽工程和变构位点靶向调控血管紧张素II 1型受体的正性肌力信号传导

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01259
Hadjadj, Margot; Hassanzadeh, Malihe; Martel, Justin; Roy, Marie-Frédérique; Giguère, Hugo; Murza, Alexandre; Holleran, Brian J; Namkung, Yoon; Froehlich, Ulrike; Leduc, Richard; Auger-Messier, Mannix; Laporte, Stéphane A; Boudreault, Pierre-Luc
信号转导
发表日期：2026
文献求助 收藏

Structural basis of TMPRSS11D specificity and autocleavage activation.

TMPRSS11D 特异性和自切割激活的结构基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59677-3
Fraser Bryan J, Wilson Ryan P, Ferková Sára, Ilyassov Olzhas, Lac Jackie, Dong Aiping, Li Yen-Yen, Seitova Alma, Li Yanjun, Hejazi Zahra, Kenney Tristan M G, Penn Linda Z, Edwards Aled, Leduc Richard, Boudreault Pierre-Luc, Morin Gregg B, Bénard François, Arrowsmith Cheryl H
发表日期：2025
文献求助 收藏

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6

结构导向的TMPRSS6选择性共价可逆肽模拟抑制剂的优化

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01998
Guerrab, Walid; Lepage, Matthieu; Désilets, Antoine; Joushomme, Alexandre; Desgagné, Michael; Froehlich, Ulrike; Leduc, Richard; Boudreault, Pierre-Luc
发表日期：2025
文献求助 收藏

From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.

从 N-0385 到 N-0920：揭示了一种宿主导向的蛋白酶抑制剂，对流行的 SARS-CoV-2 变种具有皮摩尔级的抗病毒功效

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02468
Lemieux Gabriel, Pérez-Vargas Jimena, Désilets Antoine, Hassanzadeh Malihe, Thompson Connor A H, Gravel-Trudeau Alice, Joushomme Alexandre, Ennis Siobhan, Villanueva Ivan, Marouseau Étienne, Fraser Bryan J, Champagne William, Lepage Matthieu, Niikura Masahiro, Arrowsmith Cheryl H, Jean François, Leduc Richard, Boudreault Pierre-Luc
炎症/感染
新冠
Viral
发表日期：2025
文献求助 收藏

Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency

开发具有低纳摩尔效力的酮苯并噻唑类肽模拟TMPRSS13抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2466841
Joushomme, Alexandre; Désilets, Antoine; Champagne, William; Hassanzadeh, Malihe; Lemieux, Gabriel; Gravel-Trudeau, Alice; Lepage, Matthieu; Lafrenière, Sabrina; Froehlich, Ulrike; List, Karin; Boudreault, Pierre-Luc; Leduc, Richard
发表日期：2025
文献求助 收藏

Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals.

解码 ADGRE5：蛋白水解切割和机械力如何释放细胞信号

期刊:Cells
影响因子:5.2
doi:10.3390/cells14161284
Moreno-Salinas Ana L, Mancini Arturo, Aouad Samya, Kandasamy Herthana, Morissette Sandra, Maiga Arhamatoulaye, Bouvier Michel, Leduc Richard, Sabbagh Laurent
信号转导
细胞生物学
发表日期：2025
文献求助 收藏

Proteoform-predictor: Increasing the Phylogenetic Reach of Top-Down Proteomics

蛋白质异构体预测器：扩大自上而下蛋白质组学的系统发育范围

期刊:Journal of Proteome Research
影响因子:3.6
doi:10.1021/acs.jproteome.4c00943
Su, Taojunfeng; Fellers, Ryan T; Greer, Joseph B; LeDuc, Richard D; Thomas, Paul M; Kelleher, Neil L
发育与干细胞
发表日期：2025
文献求助 收藏

A110 SUSTAINABILITY IN EVERYDAY GI PRACTICE: QUANTIFYING TRAVEL RELATED CARBON EMISSIONS FOR IN-PERSON APPOINTMENTS AND MODELS FOR REDUCTION THROUGH USE OF TELEHEALTH

A110 日常胃肠病诊疗实践中的可持续性：量化面对面就诊的出行相关碳排放以及通过远程医疗减少碳排放的模式

期刊:Atmospheric Pollution Research
影响因子:3.5
doi:10.1016/j.apr.2016.10.009
Provençal, Simon; Buchard, Virginie; da Silva, Arlindo M; Leduc, Richard; Barrette, Nathalie; Galts, C; Anvari, S; Leontiadis, G
发表日期：2025
文献求助 收藏

Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients

突触核蛋白病患者阑尾中易聚集的α-突触核蛋白蛋白异构体和失调的分子特征

期刊:
影响因子:
doi:10.1101/2025.10.07.680938
Anis, Ehraz; Zameer, Saima; Wierenga, Joshua; Li, Peipei; Sikora, Jacek W; Gordevicius, Juozas; Schilthuis, Meghan; LeDuc, Richard D; Kordower, Jeffery H; Pinho, Michelle; Pritzkow, Sandra; Soto, Claudio; Brundin, Patrik; Brundin, Lena; Killinger, B A
神经科学
发表日期：2025
文献求助 收藏