日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants

高通量筛选鉴定出一种与长QT综合征相关的KCNQ1变异体的转运校正因子

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.201297
Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R
发表日期：2026
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Recent developments in cystic fibrosis drug discovery: where are we today?

囊性纤维化药物研发的最新进展：我们目前处于什么阶段？

期刊:Expert Opinion on Drug Discovery
影响因子:4.9
doi:10.1080/17460441.2025.2490250
Lopes-Pacheco, Miquéias; Winters, Ashlyn G; Jackson, JaNise J; Olson, John A 3rd; Kim, Minsoo; Ledwitch, Kaitlyn V; Tedman, Austin; Jhangiani, Ashish R; Schlebach, Jonathan P; Meiler, Jens; Plate, Lars; Oliver, Kathryn E
发表日期：2025
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Classification models distinguish functional and trafficking effects of KCNQ1 variants to enhance variant interpretation

分类模型区分KCNQ1变异体的功能效应和转运效应，以增强对变异体的解读。

期刊:
影响因子:
doi:10.1101/2025.10.31.685955
Chang-Gonzalez, Ana C; Bell, Eric W; Vanoye, Carlos G; Guadarrama, Eduardo; Desai, Reshma R; DeKeyser, Jean-Marc; Butcher, Kathryn R; Scott, Thomas; Sanders, Charles R; George, Alfred L Jr; Ledwitch, Kaitlyn V; Meiler, Jens
发表日期：2025
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High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

高通量筛选鉴定出一种针对长QT综合征相关KCNQ1变异的小分子转运校正剂

期刊:
影响因子:
doi:10.1101/2025.10.13.682066
Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R
发表日期：2025
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Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologics

分析EGFR结合热点以设计新型EGFR抑制性生物制剂

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.5141
Tydings, Claiborne W; Singh, Bhuminder; Smith, Adam W; Ledwitch, Kaitlyn V; Brown, Benjamin P; Lovly, Christine M; Walker, Allison S; Meiler, Jens
EGFR
EGF
发表日期：2024
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Dark nanodiscs for evaluating membrane protein thermostability by differential scanning fluorimetry

利用差示扫描荧光法评估膜蛋白热稳定性的暗纳米盘

期刊:Biophysical Journal
影响因子:3.1
doi:10.1016/j.bpj.2023.11.019
Selvasingh, Jazlyn A; McDonald, Eli F; Neufer, Preston D; McKinney, Jacob R; Meiler, Jens; Ledwitch, Kaitlyn V
IF
发表日期：2024
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Targeting in silico GPCR conformations with ultra-large library screening for hit discovery

利用超大规模文库筛选靶向计算机模拟的GPCR构象以发现先导化合物

期刊:Trends in Pharmacological Sciences
影响因子:19.9
doi:10.1016/j.tips.2022.12.006
Sala, D; Batebi, H; Ledwitch, K; Hildebrand, P W; Meiler, J
GPCR/Calcium/cAMP
发表日期：2023
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Computational modeling and prediction of deletion mutants

缺失突变体的计算建模和预测

期刊:Structure
影响因子:4.4
doi:10.1016/j.str.2023.04.005.
Hope Woods ,Dominic L Schiano ,Jonathan I Aguirre ,Kaitlyn V Ledwitch ,Eli F McDonald ,Markus Voehler ,Jens Meiler ,Clara T Schoeder
发表日期：2023
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Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction

从非典型氨基酸连接镧系元素标签获得的稀疏拟接触位移核磁共振数据可改善膜蛋白整体结构预测

期刊:Journal of Biomolecular NMR
影响因子:2.4
doi:10.1007/s10858-023-00412-9
Kaitlyn V Ledwitch, Georg Künze, Jacob R McKinney, Elleansar Okwei, Katherine Larochelle, Lisa Pankewitz, Soumya Ganguly, Heather L Darling, Irene Coin, Jens Meiler
发表日期：2023
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Dark nanodiscs as a model membrane for evaluating membrane protein thermostability by differential scanning fluorimetry

以暗纳米圆盘为模型膜，通过差示扫描荧光法评估膜蛋白的热稳定性

期刊:
影响因子:
doi:10.1101/2023.05.08.539917
Jazlyn A Selvasingh, Eli Fritz McDonald, Jacob R Mckinney, Jens Meiler, Kaitlyn V Ledwitch
IF
发表日期：2023
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