日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-throughput chemical proteomics workflow for profiling protein citrullination dynamics.

用于分析蛋白质瓜氨酸化动态的高通量化学蛋白质组学工作流程。

Meelker González Rebecca, Laposchan Sophia, Riedel Erik, Fürst Anna, O'Sullivan Naomi, Gabriel Wassim, Wilhelm Mathias, Knolle Percy A, Médard Guillaume, Kuster Bernhard, Lee Chien-Yun

Development of motif-specific monoclonal antibodies for global protein citrullination detection with minimal cross-reactivity to homocitrullination

开发针对特定基序的单克隆抗体,用于检测蛋白质整体瓜氨酸化,且与同型瓜氨酸化的交叉反应性极低。

Laposchan, Sophia; Riedel, Erik; Flatley, Andrew; Pasquero, Selina; Feederle, Regina; Lee, Chien-Yun

Promoter hypomethylation drives ABCB1-mediated carfilzomib resistance in multiple myeloma

启动子低甲基化驱动多发性骨髓瘤中ABCB1介导的卡非佐米耐药性

Han, Seungbin; Haertle, Larissa; Munawar, Umair; Truger, Marietta; Hainold, Ann-Sophie; Lee, Chien-Yun; Kurian, Shilpa; Verbruggen, Christina; Nerreter, Silvia; Vogt, Cornelia; Besant, Emma; Rein, Nina; Lehmann, Johanna; Köppel, Max; Tamamushi, Yoko; Zhou, Xiang; Steinbrunn, Torsten; Haaf, Thomas; Küster, Bernhard; Slaby, Ondrej; Haferlach, Claudia; Einsele, Hermann; Rasche, Leo; Waldschmidt, Johannes; Besse, Andrej; Driessen, Christoph; Besse, Lenka; Kortüm, K Martin

Citrullination negatively regulates the functions of the p53 protein and opposes its ubiquitination and degradation

瓜氨酸化负调控p53蛋白的功能,并抑制其泛素化和降解。

Yang, Yi-Fang; Lee, Chien-Yun; Liu, Guang-Yaw; Hsieh, Ju-Yi; Lin, Yi-Chun; Wang, Li-Wei; Chan, Kai-Han; Yen, Won-Shin; Chen, Yin-Chu; Lin, Chi-Li; Hung, Hui-Chih

Deep Learning Enhances Precision of Citrullination Identification in Human and Plant Tissue Proteomes

深度学习提高了人和植物组织蛋白质组中瓜氨酸化鉴定的精确度

Gabriel, Wassim; González, Rebecca Meelker; Laposchan, Sophia; Riedel, Erik; Dündar, Gönül; Poppenberger, Brigitte; Wilhelm, Mathias; Lee, Chien-Yun

Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics.

利用磷酸化蛋白质组学揭示肉瘤细胞对激酶抑制剂的表型药物反应

Lee Chien-Yun, The Matthew, Meng Chen, Bayer Florian P, Putzker Kerstin, Müller Julian, Streubel Johanna, Woortman Julia, Sakhteman Amirhossein, Resch Moritz, Schneider Annika, Wilhelm Stephanie, Kuster Bernhard

Mining the Human Tissue Proteome for Protein Citrullination

挖掘人体组织蛋白质组中的蛋白质瓜氨酸化现象

Lee, Chien-Yun; Wang, Dongxue; Wilhelm, Mathias; Zolg, Daniel P; Schmidt, Tobias; Schnatbaum, Karsten; Reimer, Ulf; Pontén, Fredrik; Uhlén, Mathias; Hahne, Hannes; Kuster, Bernhard

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

人肽基精氨酸脱亚胺酶4的二聚体界面与底物结合位点之间的分子相互作用

Lee, Chien-Yun; Lin, Chu-Cheng; Liu, Yi-Liang; Liu, Guang-Yaw; Liu, Jyung-Hurng; Hung, Hui-Chih

Functional roles of the dimer-interface residues in human ornithine decarboxylase

人鸟氨酸脱羧酶二聚体界面残基的功能作用

Lee, Chien-Yun; Liu, Yi-Liang; Lin, Chih-Li; Liu, Guang-Yaw; Hung, Hui-Chih