日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types.

整合多尺度计算机模拟和实验数据的框架预测 CAR-NK 细胞对不同靶细胞类型的细胞毒性。

Ahmad Saeed, Xing Kun, Pereira Marcelo S F, Castle Stephanie, Rajakaruna Harshana, Nayak Indrani, Stewart William C, Beckwith Kyle A, Cairo Mitchell S, Naeimi Kararoudi Meisam, Lee Dean A, Das Jayajit

Molecular approaches drive the raceCAR team against cancer

分子生物学方法驱动着赛车队对抗癌症。

Lee, Dean A

Erratum: Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

更正:在体外和体内NB异种移植模型中,抗ROR1 CAR NK细胞与N-803联合应用可有效靶向神经母细胞瘤

Chu, Yaya; Nayyar, Gaurav; Tian, Meijuan; Lee, Dean A; Ozkaynak, Mehmet F; Ayala-Cuesta, Jessica; Klose, Kayleigh; Foley, Keira; Mendelowitz, Alyssa S; Luo, Wen; Liao, Yanling; Ayello, Janet; Behbehani, Gregory K; Riddell, Stanley; Cripe, Timothy P; Cairo, Mitchell S

Trabectedin decreases myeloid resistance to improve the efficacy of anti-PD1 immunotherapy and delay glioma malignant progression.

曲贝替定可降低髓系抵抗力,从而提高抗 PD-1 免疫疗法的疗效并延缓胶质瘤的恶性进展。

Nazzaro Matthew, Mardis Elaine R, Canella Alessandro, Bhinder Bhavneet, Elemento Olivier, Behbehani Gregory, Currier Mark, Glaspell Andrea, Lee Dean A, Cripe Timothy P, Rajappa Prajwal

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements

NK细胞的基因调控程序表明,NCAM1(CD56)和KIRs受遗传多态性远端调控元件的控制

Salem, Mariam A; Varkey, Aditi; Estrada, Matthew D; Sharma, Kruthika; Eisele, Caprice D; Chakravarti, Nitin; Lee, Dean A; Freud, Aharon G; Mundy-Bosse, Bethany L; Collins, Patrick L

High-throughput drug screening identifies SMAC mimetics as enhancers of NK-cell cytotoxicity in chronic myeloid leukemia

高通量药物筛选发现SMAC模拟物可增强慢性粒细胞白血病中NK细胞的细胞毒性。

Nygrén, Petra; Bouhlal, Jonas; Jokinen, Emmi; Forstén, Sofia; Laajala, Essi; Dias, Diogo; Adnan-Awad, Shady; Ianevski, Aleksandr; Klievink, Jay; Lähteenmäki, Hanna; Kuusanmäki, Heikki; Myllymäki, Mikko; Kasanen, Tiina; Saeed, Khalid; Lee, Dean A; Hjorth-Hansen, Henrik; Aittokallio, Tero; Dufva, Olli; Mustjoki, Satu

IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy

IL-21重编程的Vδ1 T细胞可杀伤实体瘤,而CAR修饰可增强其杀伤作用,使其成为一种现成的免疫疗法。

Portillo, Ana L; Mehboob, Misaal; Snyder, Genesis; Moinuddin, Adnan; Ritchie, Tyrah M; Balint, Elizabeth; Moore, Allyson E; Sookhaklari, Mohammadamin; Bramson, Jonathan L; Lee, Dean A; Naeimi Kararoudi, Meisam; Ashkar, Ali A

Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ

皮肤中的自然杀伤细胞:更好地了解被忽视的次级淋巴器官诸多方面的独特机会

Johnson, Kirsten M; Lee, Dean A

Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma

采用抗ROR1 CAR NK细胞和分泌IL-21的溶瘤病毒联合免疫疗法治疗神经母细胞瘤

Chu, Yaya; Tian, Meijuan; Saini, Uksha; Ayala-Cuesta, Jessica; Klose, Kayleigh; Mendelowitz, Alyssa S; Foley, Keira; Ozkaynak, Mehmet F; Luo, Wen; Cripe, Timothy P; Lee, Dean A; Cassady, Kevin A; Cairo, Mitchell S

Bringing in cytokine support troops with an OV Trojan horse

利用 OV 特洛伊木马引入细胞因子支援部队

Lee, Dean A; Pereira, Marcelo S F