日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

In Silico Discovery of 5'-Modified 7-Deoxy-7-ethynyl-4'-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor

利用计算机模拟发现 5'-修饰的 7-脱氧-7-乙炔基-4'-硫代腺苷作为 HASPIN 抑制剂及其与 PLK1 抑制剂的协同抗癌作用

期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.3c00332
Kwon, Eun-Ji; Mashelkar, Karishma K; Seo, Juhee; Shin, Yoon-Ze; Sung, Kisu; Jang, Sung Chul; Cheon, Sang Won; Lee, Haeseung; Lee, Hyuk Woo; Kim, Gyudong; Han, Byung Woo; Lee, Sang Kook; Jeong, Lak Shin; Cha, Hyuk-Jin
肿瘤
HASP
肿瘤免疫
PLK1
发表日期：2023
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Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A(2A)/A(3) Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.

截短的 2,8-二取代腺苷衍生物作为双重 A(2A)/A(3) 腺苷受体拮抗剂的构效关系及其癌症免疫治疗活性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c00806
Kim Gibae, Hou Xiyan, Byun Woong Sub, Kim Gyudong, Jarhad Dnyandev B, Lee Grim, Hyun Young Eum, Yu Jinha, Lee Chang Soo, Qu Shuhao, Warnick Eugene, Gao Zhan-Guo, Kim Ji Yong, Ji Seunghee, Shin Hyunwoo, Choi Jong-Ryoul, Jacobson Kenneth A, Lee Hyuk Woo, Lee Sang Kook, Jeong Lak Shin
免疫/内分泌
发表日期：2023
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Discovery of a Novel Template, 7-Substituted 7-Deaza-4'-Thioadenosine Derivatives as Multi-Kinase Inhibitors

发现一种新型模板化合物，7-取代的7-脱氮-4'-硫代腺苷衍生物作为多激酶抑制剂

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph14121290
Mashelkar, Karishma K; Byun, Woong Sub; Ko, Hyejin; Sung, Kisu; Tripathi, Sushil K; An, Seungchan; Yum, Yun A; Kwon, Jee Youn; Kim, Minjae; Kim, Gibae; Kwon, Eun-Ji; Lee, Hyuk Woo; Noh, Minsoo; Lee, Sang Kook; Jeong, Lak Shin
信号转导
发表日期：2021
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Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.

新型模板截短的 1'-同系腺苷衍生物作为纯粹的双重 PPARα/α 调节剂的发现和构效关系

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.0c01874
An Seungchan, Kim Gyudong, Kim Hyun Jin, Ahn Sungjin, Kim Hyun Young, Ko Hyejin, Hyun Young Eum, Nguyen Mai, Jeong Juri, Liu Zijing, Han Jinhe, Choi Hongseok, Yu Jinha, Kim Ji Won, Lee Hyuk Woo, Jacobson Kenneth A, Cho Won Jea, Kim Young-Mi, Kang Keon Wook, Noh Minsoo, Jeong Lak Shin
其它
发表日期：2020
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6'-β-Fluoro-Homoaristeromycin and 6'-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1

6'-β-氟-高阿利斯特霉素和6'-氟-高诺霉素A通过直接作用于病毒非结构蛋白1，成为基孔肯雅病毒复制的强效抑制剂。

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02532-19
Kovacikova, Kristina; Morren, Bas M; Tas, Ali; Albulescu, Irina C; van Rijswijk, Robin; Jarhad, Dnyandev B; Shin, Young Sup; Jang, Min Hwan; Kim, Gyudong; Lee, Hyuk Woo; Jeong, Lak Shin; Snijder, Eric J; van Hemert, Martijn J
微生物学
发表日期：2020
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Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues

6'-氟代阿利司霉素类似物的设计、合成及抗RNA病毒活性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.9b00781
Yoon, Ji-Seong; Kim, Gyudong; Jarhad, Dnyandev B; Kim, Hong-Rae; Shin, Young-Sup; Qu, Shuhao; Sahu, Pramod K; Kim, Hea Ok; Lee, Hyuk Woo; Wang, Su Bin; Kong, Yun Jeong; Chang, Tong-Shin; Ogando, Natacha S; Kovacikova, Kristina; Snijder, Eric J; Posthuma, Clara C; van Hemert, Martijn J; Jeong, Lak Shin
微生物学
发表日期：2019
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A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats

A3腺苷受体激动剂可减轻大鼠脑缺血损伤并抑制炎症细胞迁移

期刊:American Journal of Pathology
影响因子:3.6
doi:10.1016/j.ajpath.2011.07.006
Choi, In-Young; Lee, Jae-Chul; Ju, Chung; Hwang, Sunyoung; Cho, Geum-Sil; Lee, Hyuk Woo; Choi, Won Jun; Jeong, Lak Shin; Kim, Won-Ki
炎症
炎症/感染
信号转导
Rat
神经科学
细胞生物学
发表日期：2011
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Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists

2-氯-N6-取代-4'-硫代腺苷-5'-N,N-二烷基糖醛酸酰胺作为人A3腺苷受体拮抗剂的构效关系

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2008.01.070
Jeong, Lak Shin; Lee, Hyuk Woo; Kim, Hea Ok; Tosh, Dilip K; Pal, Shantanu; Choi, Won Jun; Gao, Zhan-Guo; Patel, Amit R; Williams, Wanda; Jacobson, Kenneth A; Kim, Hee-Doo
信号转导
发表日期：2008
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Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety

通过修饰 5'-核糖呋喃-尿酰胺部分将 A3 腺苷受体激动剂转化为选择性拮抗剂

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2005.10.054
Gao, Zhan-Guo; Joshi, Bhalchandra V; Klutz, Athena M; Kim, Soo-Kyung; Lee, Hyuk Woo; Kim, Hea Ok; Jeong, Lak Shin; Jacobson, Kenneth A
信号转导
发表日期：2006
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