日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis

发现一种ITK和TRK激酶抑制剂,可用于治疗特应性皮炎。

Duffen, Jennifer L; Crouse, Kimberly K; Ji, Lin; Brault, Amy L; Ford, Kristen; Brooks, Jonathan; Jelinsky, Scott A; Li, Yizheng; Shin, Julia H; Zhao, Yajuan; Andreyeva, Tatyana; Hammerman, Katherine; Arnold, Christina; Sheldon, Richard T; Garren, Jeonifer; LaBarge, Wes; Resek, Anthony; Volmer, Jon; Bagley, Scott W; Casimiro-Garcia, Agustin; Chinigo, Gary M; Davoren, Jennifer E; Denny, Rajiah Aldrin; Drozda, Susan; Foley, Timothy L; Hicklin, Robert W; Liu, Shenping; Lovering, Frank E; Nedoma, Nicole L; Parikh, Mihir D; Strohbach, Joseph W; Trujillo, John I; Steyn, Stefanus J; Nocka, Karl; Hegen, Martin; Vincent, Fabien; Lee, Katherine L; Gerstenberger, Brian S; Primiano, Michael J

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca(2+) dependent allosteric binding site.

通过靶向 Ca(2+) 依赖性变构结合位点来抑制肽基精氨酸脱亚胺酶 (PAD1-4)

Dakin Leslie A, Xing Li, Hall Justin, Ding Weidong, Vajdos Felix F, Pelker Jeffrey W, Ramsey Simeon, Balbo Paul, Sahasrabudhe Parag V, Banker Mary Ellen, Choi Won Young, Wright Stephen W, Chang Jeanne S, Curto John M, Davoren Jennifer E, Drozda Susan E, Fennell Kimberly F, Futatsugi Kentaro, Kortum Steve, Lee Katherine L, Liu Shenping, Lovering Frank, Nicki Jennifer A, Trujillo John I, Vincent Fabien, Schnute Mark E

Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule

通过置换被捕获的水分子来优化肽基精氨酸脱亚胺酶(PAD)抑制剂

Schnute, Mark E; Chinigo, Gary M; Futatsugi, Kentaro; Yamaguchi, Masaya; Bagley, Scott W; Banker, Mary Ellen; Chang, Jeanne S; Chen, Ming Z; Choi, Won Young; Corbett, Matthew S; Drozda, Susan E; Ebner, David C; Garcia-Irizarry, Carmen; Hicklin, Robert; Hoy, Susan; Jiao, Wenhua; Kortum, Steven; Lee, Katherine L; Limburg, David C; Lovering, Frank; Moreno, Antonio; Mousseau, James J; Pan, Senliang; Parikh, Mihir D; Pelker, Jeffrey W; Ramsey, Simeon; Reilly, Usa; Rescourio, Gwenaella; Schmitt, Daniel C; Simpson, Brittany; Skrzypek, Grzegorz J; Smaltz, Daniel J; Taylor, Alexandria P; Torella, Rubben; Trujillo, John I; Vajdos, Felix F; Wepy, James A; Wright, Stephen W; Blakemore, David C; Vincent, Fabien; Clerin, Valerie M

In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)

回顾:IRAK4抑制剂Zimlovisertib(PF-06650833)结构-活性关系的根本原因分析

Wright, Stephen W; Farley, Kathleen A; Han, Seungil; Knafels, John D; Lee, Katherine L

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists

大环维甲酸受体相关孤儿受体C2反向激动剂

Schnute, Mark E; Trujillo, John I; Lee, Katherine L; Unwalla, Ray; Vajdos, Felix F; Kauppi, Björn; Nuhant, Philippe; Flick, Andrew C; Crouse, Kimberly K; Zhao, Yajuan; Samuel, Amanda; Lombardo, Vincent; Taylor, Alexandria P; Brault, Amy L; Knafels, John D; Vazquez, Michael L; Berstein, Gabriel

Cancer Niche as a Garbage Disposal Machine: Implications of TCM-Mediated Balance of Body-Disease for Treatment of Cancer

癌症微环境如同垃圾处理机:中医介导的身心平衡对癌症治疗的启示

Li, Shengwen Calvin; Luo, Jane; Lee, Katherine L

Phosphatases Generate Signal Specificity Downstream of Ssp1 Kinase in Fission Yeast

磷酸酶在裂殖酵母中产生 Ssp1 激酶下游的信号特异性

Lin Deng, Mid Eum Lee, Katherine L Schutt, James B Moseley

Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target

患者匹配的脑和颅外黑色素瘤转移的分子分析表明 PI3K 通路可作为治疗靶点

Guo Chen, Nitin Chakravarti, Kimberly Aardalen, Alexander J Lazar, Michael T Tetzlaff, Bradley Wubbenhorst, Sang-Bae Kim, Scott Kopetz, Alicia A Ledoux, Y N Vashisht Gopal, Cristiano Goncalves Pereira, Wanleng Deng, Ju-Seog Lee, Katherine L Nathanson, Kenneth D Aldape, Victor G Prieto, Darrin Stuart

Control dominating subclones for managing cancer progression and posttreatment recurrence by subclonal switchboard signal: implication for new therapies

通过亚克隆信号调控优势亚克隆以控制癌症进展和治疗后复发:对新疗法的启示

Li, Shengwen Calvin; Lee, Katherine L; Luo, Jane

Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib

接受卡铂、紫杉醇和索拉非尼治疗的黑色素瘤患者中索拉非尼靶点的表达

Lucia Jilaveanu, Christopher Zito, Sandra J Lee, Katherine L Nathanson, Robert L Camp, David L Rimm, Keith T Flaherty, Harriet M Kluger