日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Characterization of difficult-to-remove host cell proteins in adeno-associated virus downstream processing

腺相关病毒下游加工过程中难以去除的宿主细胞蛋白的特性分析

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2025.101623
Leibiger, Thomas M; Min, Lie; Lee, Kelvin H
微生物学
细胞生物学
发表日期：2025
文献求助 收藏

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

HEK293悬浮细胞培养基的开发、瞬时转染优化工作流程以及批量rAAV生产的分析

期刊:Biotechnology and Bioengineering
影响因子:3.6
doi:10.1002/bit.28980
Green Erica A, Fu Qiang, Ndahiro Nelson, Leibiger Thomas M, Wang Yongdan, Lee Yongsuk, Lee Kelvin H, Betenbaugh Michael, Yoon Seongkyu, McNally David J
细胞生物学
发表日期：2025
文献求助 收藏

Evaluation of "Difficult-to-Express" Monoclonal Antibodies in a CHO-Based Hybrid Site-Specific Integration System Under Industrially Relevant Conditions

在工业相关条件下，对基于CHO细胞的混合位点特异性整合系统中“难表达”单克隆抗体进行评价

期刊:Biotechnology Journal
影响因子:3.1
doi:10.1002/biot.70102
Szkodny, Alana C; Lee, Kelvin H
单克隆抗体
细胞生物学
发表日期：2025
文献求助 收藏

A Flexible Hybrid Site-Specific Integration-Based Expression System in CHO Cells for Higher-Throughput Evaluation of Monoclonal Antibody Expression Cassettes

一种用于CHO细胞中单克隆抗体表达盒高通量评估的灵活混合位点特异性整合表达系统

期刊:Biotechnology Journal
影响因子:3.1
doi:10.1002/biot.202400520
Szkodny, Alana C; Lee, Kelvin H
单克隆抗体
细胞生物学
发表日期：2025
文献求助 收藏

Development and Characterization of the NISTCHO Reference Cell Line.

NISTCHO参考细胞系的建立和表征

期刊:Biotechnology Journal
影响因子:3.1
doi:10.1002/biot.70012
Dahodwala Hussain, Hodzic Irfan, Slesarev Alexei, Cutak Benjamin, Kuzin Alexander, Lal Rahul, Liu Jiajian, Mahon James, Narasimhan Rajagopalan Lakshmi, Onuska Jaya, Ravellette James, Reger Kelsey, Sakurada Sadie, Stewart Floy, Borgschulte Trissa, Cote Colette, Lee Kelvin H, O'Dell William B, Kelman Zvi, Anderson Britta A
细胞生物学
发表日期：2025
文献求助 收藏

Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development

生物层干涉法在腺相关病毒衣壳滴度测定中的应用及其在上游和下游工艺开发中的应用

期刊:Molecular Therapy-Methods & Clinical Development
影响因子:4.7
doi:10.1016/j.omtm.2024.101306
Leibiger, Thomas M; Remmler, Luke A; Green, Erica A; Lee, Kelvin H
微生物学
发表日期：2024
文献求助 收藏

Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing

单克隆抗体生物加工中CHO宿主细胞蛋白的鉴定和表征

期刊:Biotechnology and Bioengineering
影响因子:3.6
doi:10.1002/bit.28568
Oh, Young Hoon; Mendola, Kerri M; Choe, Leila H; Min, Lie; Lavoie, Ashton R; Sripada, Sobhana A; Williams, Taufika Islam; Lee, Kelvin H; Yigzaw, Yinges; Seay, Alexander; Bill, Jerome; Li, Xuanwen; Roush, David J; Cramer, Steven M; Menegatti, Stefano; Lenhoff, Abraham M
单克隆抗体
细胞生物学
发表日期：2024
文献求助 收藏

NIIMBL's viral vector program: A cross-gene therapy community collaboration to transform viral vector development and manufacturing

NIIMBL的病毒载体项目：一项跨基因治疗领域的合作，旨在变革病毒载体的开发和生产。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2023.11.009
Lee, Kelvin H; Gao, Guangping
微生物学
基因治疗
发表日期：2023
文献求助 收藏

Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

确定设计空间以优化瞬时rAAV生产中的DNA复合物形成和完整衣壳形成

期刊:Biotechnology and Bioengineering
影响因子:3.6
doi:10.1002/bit.28508
Fu, Qiang; Lee, Yong Suk; Green, Erica A; Wang, Yongdan; Park, So Young; Polanco, Ashli; Lee, Kelvin H; Betenbaugh, Michael; McNally, David; Yoon, Seongkyu
发表日期：2023
文献求助 收藏

Bioindustrial manufacturing readiness levels (BioMRLs) as a shared framework for measuring and communicating the maturity of bioproduct manufacturing processes

生物工业生产准备度等级（BioMRLs）作为衡量和交流生物产品生产工艺成熟度的共享框架

期刊:Journal of Industrial Microbiology & Biotechnology
影响因子:3.2
doi:10.1093/jimb/kuac022
Smanski, Michael J; Aristidou, Aristos; Carruth, Ryan; Erickson, John; Gordon, Mark; Kedia, Sandeep B; Lee, Kelvin H; Prather, Darcy; Schiel, John E; Schultheisz, Heather; Treynor, Thomas P; Evans, Steven L; Friedman, Douglas C; Tomczak, Melanie
发表日期：2022
文献求助 收藏