日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MK-7602: a potent multi-stage dual-targeting antimalarial

MK-7602:一种强效的多阶段双靶点抗疟药

Favuzza, Paola; Palandri, Josephine; de Lera Ruiz, Manuel; Bailey, Wendy; Boyce, Christopher W; Danziger, Andrew; Fawaz, Maria V; Kelly, Michael; Murgolo, Nicholas; Robbins, Jonathan A; Vavrek, Marissa; Zhao, Lianyun; Lei, Zhiyu; Guo, Zhuyan; Reaksudsan, Kitsanapong; Steel, Ryan W J; Hodder, Anthony N; Ngo, Anna; Dziekan, Jerzy M; Thompson, Jennifer K; Triglia, Tony; Birkinshaw, Richard W; Penington, Jocelyn Sietsma; Scally, Stephen W; Dans, Madeline G; Coyle, Rachael; Sevilleno, Nicole; Orban, Agnes; Feufack-Donfack, Lionel Brice; Popovici, Jean; Lee, Marcus C S; Papenfuss, Anthony; Lowes, Kym N; Sleebs, Brad E; McCarthy, James S; McCauley, John A; Boddey, Justin A; Olsen, David B; Cowman, Alan F

Mechanistic insights into dual-active liver and blood-stage antiplasmodials

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R; Chen, Daisy; Plater, Andrew; Post, John; Lin, De; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C; Gamo, Fransisco-Javier; Baragaña, Beatriz; Winzeler, Elizabeth A; Lee, Marcus C S

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of Plasmodium falciparum Parasites In Vitro

蛋白质精氨酸甲基转移酶抑制剂在体外靶向恶性疟原虫的多个发育阶段

Opperman, Daniel; Rabie, Tayla; Maré, Marché; Naude, Mariska; van der Watt, Mariette; Thibaud, Jessica L; Shannon, Megan; Sanders, Nicole; Bolscher, Judith M; van der Laak, Rianne; Willemsen, Rowy; Bronkhorst, Alfred; Boonyalai, Nonlawat; Lee, Marcus C S; Birkholtz, Lyn-Marié

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

优化和表征靶向 PfATP4 的 N-乙酰胺吲哚类抗疟药

Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D; Mansouri, Mahta; Calic, Petar P S; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M; Mao, Emma Y; Gancheva, Maria R; Wilson, Danny W; Giannangelo, Carlo; MacRaild, Christopher A; Creek, Darren J; Yeo, Tomas; Sheth, Tanaya; Fidock, David A; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T; Delves, Michael J; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C S; Chowdury, Mrittika; de Koning-Ward, Tania F; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Dans, Madeline G; Sleebs, Brad E

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

对易受ROM8和CSC1突变影响的N-芳基乙酰胺类化合物的抗疟活性进行优化和表征

Nguyen, William; Boulet, Coralie; Dans, Madeline G; Loi, Katie; Jarman, Kate E; Barnes, Claudia B G; Yeo, Tomas; Sheth, Tanaya; Mukherjee, Partha; Chakraborty, Arnish; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Coyle, Rachael; Sevilleno, Nicole; Boonyalai, Nonlawat; Lee, Marcus C S; Rabie, Tayla; Birkholtz, Lyn-Marié; Baud, Delphine; Brand, Stephen; Chowdury, Mrittika; de Koning-Ward, Tania F; Fidock, David A; Gilson, Paul R; Sleebs, Brad E

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.

喹喔啉类抗血吸虫化合物具有很强的抗疟原虫活性

Rawat Mukul, Padalino Gilda, Adika Edem, Okombo John, Yeo Tomas, Brancale Andrea, Fidock David A, Hoffmann Karl F, Lee Marcus C S

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

疟原虫UBP-1中与耐药性相关的突变会破坏其必需的去泛素化活性。

Smith, Cameron J; Eavis, Heledd; Briggs, Carla; Henrici, Ryan; Karpiyevich, Maryia; Ansbro, Megan R; Hoshizaki, Johanna; van der Heden van Noort, Gerbrand J; Ascher, David B; Sutherland, Colin J; Lee, Marcus C S; Artavanis-Tsakonas, Katerina