Lee Ramee相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

亨廷顿病 LIG1 修饰基因变体可提高连接酶的保真度并抑制体细胞 CAG 重复序列扩增。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2518854123

Lee, Eunhye; Kim, Wonju; Beier, David H; Lee, Yejin; Kovalenko, Marina; Saif, Faaiza; Oliver, Esaria; Srinageshwar, Bhairavi; Murtha, Ryan; Andrew, Marissa A; Jiang, Andrew; Gillis, Tammy; Demelo, Brigitte; Ruliera, Jayla; Lucente, Diane; Kwak, Seung; Lee, Ramee; Pinto, Ricardo Mouro; MacDonald, Marcy E; Gusella, James F; O'Brien, Patrick J; Wheeler, Vanessa C; Seong, Ihn Sik

细胞生物学

发表日期：2026

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Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

doi:10.1101/2025.06.24.661398

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

细胞生物学

发表日期：2025

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Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion.

亨廷顿病 LIG1 修饰变体可提高连接酶的保真度并抑制体细胞 CAG 重复扩增

doi:10.1101/2025.07.15.664798

Lee Eunhye, Kim Wonju, Beier David H, Lee Yejin, Kovalenko Marina, Saif Faaiza, Oliver Esaria, Murtha Ryan, Andrew Marissa A, Gillis Tammy, Demelo Brigitte, Srinageshwar Bhairavi, Ruliera Jayla, Lucente Diane, Kwak Seung, Lee Ramee, Pinto Ricardo Mouro, MacDonald Marcy E, Gusella James F, O'Brien Patrick J, Wheeler Vanessa C, Seong Ihn Sik

细胞生物学

发表日期：2025

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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out

在亨廷顿病敲入小鼠中，Fan1 敲除促进体细胞 CAG 重复序列扩增的现象可被 Mlh1 敲除阻断。

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddaa196

Loupe, Jacob M; Pinto, Ricardo Mouro; Kim, Kyung-Hee; Gillis, Tammy; Mysore, Jayalakshmi S; Andrew, Marissa A; Kovalenko, Marina; Murtha, Ryan; Seong, IhnSik; Gusella, James F; Kwak, Seung; Howland, David; Lee, Ramee; Lee, Jong-Min; Wheeler, Vanessa C; MacDonald, Marcy E

细胞生物学

发表日期：2020

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Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA

突变亨廷顿蛋白3'非翻译区的完整序列及其基因调控活性受内源性microRNA调控

期刊:Journal of Human Genetics

影响因子:2.5

doi:10.1038/s10038-019-0639-8

Kim, Kyung-Hee; Abu Elneel, Kawther; Shin, Jun Wan; Keum, Jae Whan; Seong, David; Kwak, Seung; Lee, Ramee; Gusella, James F; MacDonald, Marcy E; Seong, Ihn Sik; Lee, Jong-Min

发表日期：2019

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Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR

从阿尔茨海默病患者脑组织中分离出的pro-NGF可诱导p75NTR介导的神经元凋亡。

期刊:American Journal of Pathology

影响因子:3.6

doi:10.1016/S0002-9440(10)62275-4

Pedraza, Carlos E; Podlesniy, Petar; Vidal, Noemí; Arévalo, Juan Carlos; Lee, Ramee; Hempstead, Barbara; Ferrer, Isidre; Iglesias, Montse; Espinet, Carme

阿尔茨海默症

发表日期：2005

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A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor

一种新型的p75神经营养因子受体相关蛋白NRH2，可调节神经生长因子与TrkA受体的结合。

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.3960-03.2004

Murray, Simon S; Perez, Pilar; Lee, Ramee; Hempstead, Barbara L; Chao, Moses V

发表日期：2004

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