日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation

磺胺类泛酸激酶激活剂的发现及同工酶选择性在细胞泛酸激酶激活中的作用阐明

Coker, Ashton L; Tangallapally, Rajendra; Yun, Mi-Kyung; Subramanian, Chitra; Jayasinghe, Thilina; Miller, Karen; Edwards, Anne; Frank, Matthew; Jackowski, Suzanne; Rock, Charles O; White, Stephen W; Lee, Richard E

A virtual screening and molecular dynamics approach in search of novel antibiotic chemotypes

利用虚拟筛选和分子动力学方法寻找新型抗生素化学类型

Noor, Tahira; Schultz, Daniel C; Zhai, Yuting; Snoke, Hannah E; Noh, Suyeun; Seabra, Gustavo; Lee, Richard E; Jeong, Kwangcheol Casey; Li, Chenglong; Siddiqi, Abdul Rauf

Amplicon sequencing of ice and water phytoplankton and bacterial communities during an extreme winter in a central Canadian great lake

在加拿大中部五大湖区经历极端冬季期间,对冰层和水中的浮游植物和细菌群落进行扩增子测序

Rozmarynowycz, Mark J; Brown, Katelyn M; Gantz, J D; Lee, Richard E Jr; Zastepa, Arthur; Watson, Sue; McKay, R Michael L

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus

前药氟苯尼考胺通过固有耐药性激活,靶向脓肿分枝杆菌。

Phelps, Gregory A; Kurt, Sinem; Jenner, Alexander R; Anderson, Shelby M; Jayasinghe, Thalina D; Griffith, Elizabeth C; Thompson, Carl W; Yang, Lei; Wicki, Basil; Bright, Frederick K; Loudon, Victoria; Wright, William C; Srivastava, Ashish; Singh, Amarinder; Thalluri, Bhargavi; Park, Hyunseo; Lee, Robin B; Wright, Anna K; Grant-Chapman, Oliver; Conner, Daryl K; Troyer, Brennen T; Iverson, Amy; Ochoado, Jason; Pagala, Vishwajeeth R; Wu, Long; Byrum, Stephanie; Fu, Yingxue; Yuan, Zu-Fei; High, Anthony A; Schulthess, Bettina; Rosch, Jason W; Geeleher, Paul; Hobbie, Sven N; Boeck, Lucas; Meibohm, Bernd; Obregon-Henao, Andres; Sander, Peter; Lee, Richard E

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

结核分枝杆菌通过大量重塑其脂质组,使其含有不含磷的脂质,从而克服磷酸盐缺乏。

Gray, Robert M; Hunt, Debbie M; Silva Dos Santos, Mariana; Liu, Jiuyu; Agapova, Aleksandra; Rodgers, Angela; Fearns, Antony; Canseco, Julio Ortiz; Garza-Garcia, Acely; MacRae, James I; Gutierrez, Maximiliano G; Lee, Richard E; de Carvalho, Luiz Pedro S

An open-source screening platform accelerates discovery of drug combinations

开源筛选平台加速药物组合的发现

Wright, William C; Pan, Min; Phelps, Gregory A; Low, Jonathan; Currier, Duane; Sanjali, Ankita; Trotter, Marlon; Hwang, Jihye; Chapple, Richard H; Liu, Xueying; Bennett, Declan; Zhang, Yinwen; Lee, Richard E; Chen, Taosheng; Geeleher, Paul

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

真菌病原体中海藻糖-6-磷酸合成酶活性的抑制剂会损害其耐热途径。

Miao, Yi; Yadav, Vikas; Shadrick, William; Liu, Jiuyu; Jenner, Alexander R; Nichols, Connie B; Gee, Clifford; Schäfer, Martin; Tenor, Jennifer L; Perfect, John R; Lee, Richard E; Brennan, Richard G; Washington, Erica J

Characterization of new mouse models of acute and chronic Mycobacterium abscessus infection for antimicrobial drug screening

构建急性及慢性脓肿分枝杆菌感染的新型小鼠模型用于抗菌药物筛选

Alshiraihi, Ilham M; Lam, Ha; Troyer, Brennen T; Tran, Kristina N; Zohaib Ali, Malik; Conner, Daryl K; Godelfer, Abigail; Pearce, Camron; Jackson, Mary; Henao-Tamayo, Marcela; Norcross, Sara E Maloney; Meibohm, Bernd; Lee, Richard E; Gonzalez-Juarrero, Mercedes; Obregon-Henao, Andres

Obligate diapause and its termination shape the life-cycle seasonality of an Antarctic insect

南极昆虫的专性滞育及其终止决定了其生命周期的季节性。

Yoshida, Mizuki; Convey, Peter; Hayward, Scott A L; Lee, Richard E Jr; Denlinger, David L; Teets, Nicholas M; Goto, Shin G

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

通过增强革兰氏阴性菌中二氢蝶酸合成酶蝶呤结合位点的全细胞靶向结合来开发嘧啶并哒嗪类似物

Snoke, Hannah E; Reeve, Stephanie M; Dharuman, Suresh; Wallace, Miranda J; Loudon, Victoria C; Zhao, Ying; Bowling, John J; Murphy, Patricia A; Waddell, Brett; Lee, Robin B; Bulitta, Jürgen B; Lee, Richard E