APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.
小鼠中 APOE4 到 APOE2 等位基因转换可改善阿尔茨海默病相关的代谢特征、神经病理学和认知能力。
期刊:Nature Neuroscience
影响因子:20
doi:10.1038/s41593-025-02094-y
Golden Lesley R, Siano Dahlia S, Stephens Isaiah O, MacLean Steven M, Saito Kai, Nolt Georgia L, Funnell Jessica L, Pallerla Akhil V, Lee Sangderk, Smith Cathryn, Chen Jing, Zhu Haining, Voy Clairity, Whitus Callie M, Hernandez Gabriela, Farmer Brandon C, Pandya Kumar, Cowley Dale O, Macauley Shannon L, Gordon Scott M, Morganti Josh M, Johnson Lance A
