日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL(Pro)

SARS-CoV-2 PL(Pro)片段抑制剂的发现

Wei, Qiangqiang; Taylor, Ashley J; Barmade, Mahesh Angadrao; Teuscher, Kevin B; Chowdhury, Somanath; Apakama, Chideraa; Anderson-Daniels, Jordan; Yongqing, Zhu; Schultz, David C; Rietz, Tyson A; South, Taylor M; Crow, Mackenzie M; Zhao, Bin; Amporndanai, Kangsa; Sensintaffar, John L; Phan, Jason; Cherry, Sara; Denison, Mark; Lee, Taekyu; Fesik, Stephen W

Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease

发现螺[色满-2,4'-哌啶]衍生物作为SARS-CoV-2木瓜蛋白酶样蛋白酶的不可逆抑制剂

Wei, Qiangqiang; Taylor, Ashley J; Miriyala, Nagaraju; Barmade, Mahesh A; Gentry, Zachary O; Anderson-Daniels, Jordan; Teuscher, Kevin B; Crow, Mackenzie M; Apakama, Chideraa; South, Taylor M; Rietz, Tyson A; Amporndanai, Kangsa; Phan, Jason; Sensintaffar, John L; Denison, Mark; Lee, Taekyu; Fesik, Stephen W

Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model

发现具有强效细胞活性和在小鼠实体瘤异种移植模型中体内活性的巨环髓系细胞白血病1 (Mcl-1) 抑制剂

Tarr, James C; Jeon, Kyuok; Veerasamy, Nagarathanam; Aichinger, Martin; Salovich, James M; Zhao, Bin; Sensintaffar, John L; Arnhof, Heribert; Wunberg, Tobias; Sgubin, Danielle; Arnold, Allison; Vekariya, Rakesh H; Christov, Plamen P; Kim, Kwangho; Fuchs, Julian Emanuel; Karier, Pol; Betzemeier, Bodo; Van Meveren, Mayme; Miriyala, Nagaraju; Olejniczak, Edward T; Engelhardt, Harald; Lee, Taekyu; McConnell, Darryl; Fesik, Stephen W

Culture-based characterization of gut microbiota in inflammatory bowel disease

基于培养的炎症性肠病肠道菌群特征分析

Park, Hyunjoon; Yeo, Soyoung; Lee, Taekyu; Han, Yumin; Ryu, Chang Beom; Huh, Chul Sung

The EPA oxylipin, 12-HEPE, directly regulates human platelet activity

EPA氧化脂质12-HEPE直接调节人血小板活性。

Goerger, Krista; Stanger, Livia; Rickenberg, Andrew; Nguyễn, Anthony; Lee, Taekyu; Holman, Theodore R; Holinstat, Michael

Effect of Heat Treatment Duration on the Recrystallization and Electrochemical Properties of Cold-Rolled Cantor-Type High-Entropy Alloy

热处理时间对冷轧坎托型高熵合金再结晶和电化学性能的影响

Shin, Byung-Hyun; Lim, Jinsurang; Kim, Doo-In; Ok, Jung-Woo; Kim, Seongjun; Park, Jinyong; Hong, Jonggi; Lee, Taekyu; Yoon, Jang-Hee; Lee, Je In

418 The antiplatelet effects of EPA, an omega-3 fatty acid, are mediated by its 12-lipoxygenase metabolite, 12-HEPE

418 ω-3脂肪酸EPA的抗血小板作用是由其12-脂氧合酶代谢产物12-HEPE介导的。

Wang, Sijie; Yin, Na; Li, Yongjuan; Xiang, Tingting; Jiang, Wenxiao; Zhao, Xiu; Liu, Wei; Zhang, Zhenzhong; Shi, Jinjin; Zhang, Kaixiang; Guo, Xingming; Si, Pilei; Liu, Junjie; Goerger, Krista; Lee, Taekyu; Gilmore, Devin; Tran, Michelle; Holman, Theodore R; Holinstat, Michael

Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

对WD重复结构域5抑制剂的扩展分析揭示了治疗血液系统恶性肿瘤的可行策略

Meyer, Christian T; Smith, Brianna N; Wang, Jing; Teuscher, Kevin B; Grieb, Brian C; Howard, Gregory C; Silver, Alexander J; Lorey, Shelly L; Stott, Gordon M; Moore, William J; Lee, Taekyu; Savona, Michael R; Weissmiller, April M; Liu, Qi; Quaranta, Vito; Fesik, Stephen W; Tansey, William P

Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL(pro))

基于片段的SARS-CoV-2木瓜蛋白酶样蛋白酶(PL(pro))筛选

Taylor, Ashley J; Amporndanai, Kangsa; Rietz, Tyson A; Zhao, Bin; Thiruvaipati, Anusha; Wei, Qiangqiang; South, Taylor M; Crow, Mackenzie M; Apakama, Chideraa; Sensintaffar, John L; Phan, Jason; Lee, Taekyu; Fesik, Stephen W

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

基于结构的高效WD重复结构域5抑制剂的发现,在临床前动物模型中证实了其疗效和安全性。

Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W