日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer

负选择维持转移性结直肠癌中显著改变但总体稳定的核型

Cross, William C H; Nowinski, Salpie; Cresswell, George D; Mossner, Maximilian; Banerjee, Abhirup; Lu, Bingxin; Williams, Marc J; Vlachogiannis, Georgios; Gay, Laura J; Baker, Ann-Marie; Kimberley, Christopher; Whiting, Frederick J H; Belnoue-Davis, Hayley L; Martinez, Pierre; Traki, Maria; Walther, Viola; Smith, Kane; Fernandez-Mateos, Javier; Yara-Romero, Erika; Oliveira, Erica A; Milite, Salvatore; Caravagna, Giulio; James, Chela T; Elia, George; Berner, Alison; Ryan Choi, Chang-Ho; Ramagiri, Pradeep; Chauhan, Ritika; Matthews, Nik; Murphy, Jamie; Antoniou, Anthony; Clark, Susan K; Mitchison, Miriam; Chin Aleong, Jo-Anne; Domingo, Enric; Spiteri, Inmaculada; McDonald, Stuart A C; Shibata, Darryl; Laclé, Miangela M; Wang, Lai Mun; Moorghen, Morgan; Tomlinson, Ian P M; Novelli, Marco; Jansen, Marnix; Watson, Alan; Valeri, Nicola; Wright, Nicholas A; Bridgewater, John A; Rodriguez-Justo, Manuel; Barnes, Chris P; Kocher, Hemant M; Leedham, Simon J; Sottoriva, Andrea; Graham, Trevor A

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

结直肠癌肿瘤微环境的治疗性调控和空间定量分析。

Mulholland-Illingworth Eoghan J, Moore Joshua W, Lin Muyang, Amirkhah Raheleh, Grzesiak Lucile, Ligeza Amelia, Bull Joshua A, Boen Joseph, Valbuena Gabriel N, Gillespie Michael A, Lannagan Tamsin R M, Gilroy Kathryn, Mills Megan L, Corry Shania M, Ridgway Rachel A, Belnoue-Davis Hayley L, Dunne Philip D, Sansom Owen J, Byrne Helen M, Leedham Simon J

The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt

成纤维细胞-上皮细胞相互作用在肠隐窝中不同成纤维细胞表型分布中的作用

Atkinson, George; Leedham, Simon; Byrne, Helen M

A comparison of routine blood culture methods and multiplex quantitative PCR for detecting pathogens in simulated polymicrobial blood cultures

比较常规血培养方法和多重定量PCR在模拟多微生物血培养中检测病原体的效果

Doualeh, Mariam; Mullally, Christopher; Thorsen, Martin; Raby, Edward; Litton, Edward; Leedham, Soraya; Payne, Matthew; Currie, Andrew

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA

血小板能够隔离细胞外DNA,捕获肿瘤来源的DNA和游离的胎儿DNA。

Lauren Murphy ,Jeanne Inchauspé ,Giampiero Valenzano ,Pamela Holland ,Nikolaos Sousos ,Hayley L Belnoue-Davis ,Rong Li ,Natalie J Jooss ,Camelia Benlabiod ,Eleanor Murphy ,Zohar Etzioni ,Emelie Shepherd ,Lucy Denly ,Sujata Biswas ,Lin Chen ,Jennifer O'Sullivan ,Michael P Rimmer ,Abdullah O Khan ,Christina Simoglou Karali ,Nadia Nasreddin ,Ian S Hitchcock ,Milka Koupenova ,Skirmantas Kriaucionis ,Jim R Hughes ,Eric O'Neill ,Manu Vatish ,Paul Rees ,Simon Leedham ,Michael Desborough ,Adam J Mead ,Benjamin Schuster-Böckler ,Christopher D Gregory ,Bethan Psaila

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.

低覆盖率全基因组测序可以强有力地预测溃疡性结肠炎中低级别发育不良的进展为肿瘤的风险

Al Bakir Ibrahim, Curtius Kit, Cresswell George D, Grant Heather E, Nasreddin Nadia, Smith Kane, Nowinski Salpie, Guo Qingli, Belnoue-Davis Hayley L, Fisher Jennifer, Clarke Theo, Kimberley Christopher, Mossner Maximilian, Dunne Philip D, Loughrey Maurice B, Speight Ally, East James E, Wright Nicholas A, Rodriguez-Justo Manuel, Jansen Marnix, Moorghen Morgan, Baker Ann-Marie, Leedham Simon J, Hart Ailsa L, Graham Trevor A

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.

上皮细胞 GREMLIN1 通过基质重塑破坏肠道上皮-间质细胞间的相互作用,从而诱导 Wnt 依赖性异位干细胞微环境

Mulholland Eoghan J, Belnoue-Davis Hayley L, Valbuena Gabriel N, Gunduz Nuray, Ligeza Amelia, Lin Muyang, Biswas Sujata, Gil Vasquez Ester, Omwenga Sulochana, Nasreddin Nadia, Hodder Michael C, Wang Lai Mun, Ng Aik Seng, Jennings Elizabeth, Midwood Kim S, Dedi Neesha, Irshad Shazia, Ridgway Rachel A, Phesse Toby J, East James, Tomlinson Ian Pm, Davies Gareth Cg, Sansom Owen J, Leedham Simon J

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

上皮细胞GREMLIN1通过基质重塑破坏肠道上皮-间质细胞间的相互作用,从而诱导Wnt依赖性异位干细胞微环境的形成

Eoghan J Mulholland #,Hayley L Belnoue-Davis #,Gabriel N Valbuena,Nuray Gunduz,Amelia Ligeza,Muyang Lin,Sujata Biswas,Ester Gil Vasquez,Sulochana Omwenga,Nadia Nasreddin,Michael C Hodder,Lai Mun Wang,Aik Seng Ng,Elizabeth Jennings,Kim S Midwood,Neesha Dedi,Shazia Irshad,Rachel A Ridgway,Toby J Phesse,James East,Ian Pm Tomlinson,Gareth Cg Davies,Owen J Sansom,Simon J Leedham    0

Health coaching for people with long-term conditions and multimorbidity: a mixed methods prospective service evaluation of Structured Agenda-free Coaching Conversations (StACC) in UK primary care

针对患有长期疾病和多种疾病人群的健康指导:英国基层医疗机构中结构化无议程指导对话(StACC)的混合方法前瞻性服务评估

Henry, Kate; El-Osta, Austen; Leedham-Green, Kathleen

Study protocol for putting the 'Person' in the PiCTuRE: an exploratory sequential mixed methods-based design, exploring how precision medicine is implemented and experienced by people living with a primary tumour of the craniospinal axis

将“人”置于PiCTuRE研究方案中:一项探索性序贯混合方法设计,旨在探索精准医疗在颅脊髓轴原发肿瘤患者中的实施和体验。

Mawhinney, Gerard; Higham, Helen; Leedham, Simon; Ansorge, Olaf