日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PRMT5 inhibitors actively promote metastatic progression of lung adenocarcinoma.

PRMT5抑制剂可积极促进肺腺癌的转移进展。

Fowler Colin E, O'Hearn Natalie A, Henning Nicole, Griffen Anthony, Mathey-Andrews Nicolas, Salus Griffin J, Hazan Renin, Jacks Tyler, Burds Aurora A, Mueller Helen S, Soto-Feliciano Yadira, LaFave Lindsay M, Lees Jacqueline A

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing.

PRMT5剪接轴是调控滞留内含子剪接的关键致癌脆弱点

Fowler Colin E, O'Hearn Natalie A, Salus Griffin J, Singh Arundeep, Boutz Paul L, Lees Jacqueline A

BMI1 is required for melanocyte stem cell maintenance and hair pigmentation

BMI1是维持黑色素干细胞和毛发色素沉着所必需的。

Wilson, Molly M; Danielian, Paul S; Salus, Griffin; Ferretti, Roberta; Whittaker, Charles A; Lees, Jacqueline A

MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

MITF 缺陷和致癌基因 GNAQ 均能促进斑马鱼黑素细胞谱系细胞的增殖。

Phelps, Grace B; Amsterdam, Adam; Hagen, Hannah R; García, Nicole Zambrana; Lees, Jacqueline A

Targeting the cyclin-dependent kinase 5 in metastatic melanoma

靶向转移性黑色素瘤中的细胞周期蛋白依赖性激酶5

Sharma, Samanta; Zhang, Tian; Michowski, Wojciech; Rebecca, Vito W; Xiao, Min; Ferretti, Roberta; Suski, Jan M; Bronson, Roderick T; Paulo, Joao A; Frederick, Dennie; Fassl, Anne; Boland, Genevieve M; Geng, Yan; Lees, Jacqueline A; Medema, Rene H; Herlyn, Meenhard; Gygi, Steven P; Sicinski, Piotr

The Rb tumor suppressor regulates epithelial cell migration and polarity.

Rb肿瘤抑制因子调节上皮细胞的迁移和极性

Parisi Tiziana, Balsamo Michele, Gertler Frank, Lees Jacqueline A

The awakening of the CDK10/Cyclin M protein kinase

CDK10/细胞周期蛋白M蛋白激酶的激活

Guen, Vincent J; Gamble, Carly; Lees, Jacqueline A; Colas, Pierre

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

pRb缺失的蛋白质组学分析突显了线粒体氧化磷酸化降低的特征。

Nicolay, Brandon N; Danielian, Paul S; Kottakis, Filippos; Lapek, John D Jr; Sanidas, Ioannis; Miles, Wayne O; Dehnad, Mantre; Tschöp, Katrin; Gierut, Jessica J; Manning, Amity L; Morris, Robert; Haigis, Kevin; Bardeesy, Nabeel; Lees, Jacqueline A; Haas, Wilhelm; Dyson, Nicholas J

Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1

在缺乏DICER1的情况下,小鼠肉瘤细胞系的增殖和肿瘤发生

Ravi, Arvind; Gurtan, Allan M; Kumar, Madhu S; Bhutkar, Arjun; Chin, Christine; Lu, Victoria; Lees, Jacqueline A; Jacks, Tyler; Sharp, Phillip A

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma

斑马鱼Hagoromo突变体在胚后阶段上调fgf8表达并发展为神经母细胞瘤

Amsterdam, Adam; Lai, Kevin; Komisarczuk, Anna Z; Becker, Thomas S; Bronson, Roderick T; Hopkins, Nancy; Lees, Jacqueline A