日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development

粘多糖贮积症 VI 的骨骼表型改善需要在出生后发育的最早阶段进行干预

Elizabeth Hwang-Wong, Gabrielle Amar, Nanditha Das, Xiaoli Zhang, Nina Aaron, Kirsten Gale, Nyanza Rothman, Massimo Fante, Andrew Baik, Ajay Bhargava, Arun Fricker, Michelle McAlister, Jeremy Rabinowitz, John Lees-Shepard, Kalyan Nannuru, Aris N Economides, Katherine D Cygnar

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

抗ACVR1抗体通过激活进行性骨化性纤维发育不良(FOP)突变型ACVR1,加剧FOP中的异位骨化。

Senem Aykul,Lily Huang,Lili Wang,Nanditha M Das,Sandra Reisman,Yonaton Ray,Qian Zhang,Nyanza Rothman,Kalyan C Nannuru,Vishal Kamat,Susannah Brydges,Luca Troncone,Laura Johnsen,Paul B Yu,Sergio Fazio,John Lees-Shepard,Kevin Schutz,Andrew J Murphy,Aris N Economides,Vincent Idone,Sarah J Hatsell

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

抗ACVR1抗体可加剧进行性骨化性纤维发育不良小鼠体内纤维脂肪祖细胞的异位骨化。

John B Lees-Shepard ,Sean J Stoessel ,Julian T Chandler ,Keith Bouchard ,Patricia Bento ,Lorraine N Apuzzo ,Parvathi M Devarakonda ,Jeffrey W Hunter ,David J Goldhamer

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

激活素 A 通过其指尖环与 ACVR1 和 II 型激活素/BMP 受体形成非信号复合物

Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Tho

Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

对“帕洛伐罗汀可减少幼年FOP小鼠的异位骨化,但表现出明显的骨骼毒性”一文的评论的回应

Goldhamer, David J; Lees-Shepard, John B

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

纤维/脂肪生成祖细胞中的激活素依赖性信号导致进行性骨化性纤维发育不良

John B Lees-Shepard, Masakazu Yamamoto, Arpita A Biswas, Sean J Stoessel, Sarah-Anne E Nicholas, Cathy A Cogswell, Parvathi M Devarakonda, Michael J Schneider Jr, Samantha M Cummins, Nicholas P Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W Hunter, David J Goldhamer

Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity.

帕洛伐罗汀可减少幼年 FOP 小鼠的异位骨化,但表现出明显的骨骼毒性

Lees-Shepard John B, Nicholas Sarah-Anne E, Stoessel Sean J, Devarakonda Parvathi M, Schneider Michael J, Yamamoto Masakazu, Goldhamer David J

Stem cells and heterotopic ossification: Lessons from animal models

干细胞与异位骨化:来自动物模型的启示

Lees-Shepard, John B; Goldhamer, David J