日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral Discovery

基于结构的广谱抗病毒药物发现计算流程

Castellanos, Maria A; Payne, Alexander M; Scheen, Jenke; MacDermott-Opeskin, Hugo; Pulido, Iván; Balcomb, Blake H; Griffen, Ed J; Fearon, Daren; Barr, Haim; Lahav, Noa; Cousins, David; Stacey, Jessica; Robinson, Ralph; Lefker, Bruce; Chodera, John D

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

共价对接鉴定出一种有效且选择性的 MKK7 抑制剂

Amit Shraga, Evgenia Olshvang, Natalia Davidzohn, Payam Khoshkenar, Nicolas Germain, Khriesto Shurrush, Silvia Carvalho, Liat Avram, Shira Albeck, Tamar Unger, Bruce Lefker, Chakrapani Subramanyam, Robert L Hudkins, Amir Mitchell, Ziv Shulman, Takayoshi Kinoshita, Nir London

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

大环IL-17A拮抗剂的结合位点阐明和结构导向设计

Shenping Liu ,Leslie A Dakin ,Li Xing ,Jane M Withka ,Parag V Sahasrabudhe ,Wei Li ,Mary Ellen Banker ,Paul Balbo ,Suman Shanker ,Boris A Chrunyk ,Zuojun Guo ,Jinshan M Chen ,Jennifer A Young ,Guoyun Bai ,Jeremy T Starr ,Stephen W Wright ,Joerg Bussenius ,Sheng Tan ,Ariamala Gopalsamy ,Bruce A Lefker ,Fabien Vincent ,Lyn H Jones ,Hua Xu ,Lise R Hoth ,Kieran F Geoghegan ,Xiayang Qiu ,Mark E Bunnage ,Atli Thorarensen

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

NLRP3 炎症小体抑制剂 CP-456,773 (CRID3) 在小鼠皮肤和肺部炎症模型中的疗效和药理学

Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Paul D Bonin, Matthew Mangan, Ken Dower, Brian G Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth, J Perry Hall

An EP2 receptor-selective prostaglandin E2 agonist induces bone healing

EP2受体选择性前列腺素E2激动剂可诱导骨愈合

Paralkar, V M; Borovecki, F; Ke, H Z; Cameron, K O; Lefker, B; Grasser, W A; Owen, T A; Li, M; DaSilva-Jardine, P; Zhou, M; Dunn, R L; Dumont, F; Korsmeyer, R; Krasney, P; Brown, T A; Plowchalk, D; Vukicevic, S; Thompson, D D

Deficient flavoprotein component of the NADPH-dependent O2-.-generating oxidase in the neutrophils from three male patients with chronic granulomatous disease

三名患有慢性肉芽肿病的男性患者中性粒细胞中 NADPH 依赖性 O2- 生成氧化酶的黄素蛋白成分缺乏

Gabig, T G; Lefker, B A