rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood.
rbfox1 LoF 突变体在发育过程中表现出 bdnf/trkb2 和 crhb/nr3c2 表达紊乱和皮质醇水平升高,同时在成年期出现异质稳态超负荷的迹象。
期刊:Translational Psychiatry
影响因子:6.2
doi:10.1038/s41398-025-03703-x
Leggieri Adele, GarcÃa-González Judit, Hosseinian Saeedeh, Ashdown Peter, Anagianni Sofia, Wang Xian, Havelange William, Fernà ndez-Castillo Noèlia, Cormand Bru, Brennan Caroline H