日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Peripheral blood iNKT cells display an activated profile with both increased apoptosis and dysfunction in obesity

肥胖患者的外周血iNKT细胞表现出活化状态,同时伴有细胞凋亡增加和功能障碍。

Wilkin, Chloé; Esser, Nathalie; Lassence, Cédric; Bruneteaux, Marion; Fadeur, Marjorie; De Flines, Jenny; Paquot, Nicolas; Piette, Jacques; Legrand-Poels, Sylvie

Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

在肥胖发展为 MASH 的过程中,脂肪组织巨噬细胞浸润和肝细胞应激会增加 GDF-15 的表达。

Laurent L'homme ,Benan Pelin Sermikli ,Joel T Haas ,Sébastien Fleury ,Sandrine Quemener ,Valentine Guinot ,Emelie Barreby ,Nathalie Esser ,Robert Caiazzo ,Hélène Verkindt ,Benjamin Legendre ,Violeta Raverdy ,Lydie Cheval ,Nicolas Paquot ,Jacques Piette ,Sylvie Legrand-Poels ,Myriam Aouadi ,François Pattou ,Bart Staels ,David Dombrowicz

Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid

在 LPS 或饱和脂肪酸刺激下,IRE1 RNase 在人类巨噬细胞中 HIF-1α 介导的糖酵解上调中发挥新的 XBP1s 独立功能

Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L'homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels

New Insights on the PBMCs Phospholipidome in Obesity Demonstrate Modulations Associated with Insulin Resistance and Glycemic Status

肥胖患者外周血单核细胞磷脂组的新发现揭示了与胰岛素抵抗和血糖状态相关的调节

Wilkin, Chloé; Colonval, Megan; Dehairs, Jonas; Esser, Nathalie; Iovino, Margaud; Gianfrancesco, Marco A; Fadeur, Marjorie; Swinnen, Johan V; Paquot, Nicolas; Piette, Jacques; Legrand-Poels, Sylvie

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

饱和脂肪酸通过PERK/eIF2/CHOP信号通路促进人巨噬细胞中GDF15的表达

Laurent L'homme ,Benan Pelin Sermikli ,Bart Staels ,Jacques Piette ,Sylvie Legrand-Poels ,David Dombrowicz

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption

饱和脂肪酸通过磷脂饱和和 Na、K-ATPase 破坏导致的 K+ 外流诱导人类巨噬细胞中的 NLRP3 活化

Marco A Gianfrancesco, Jonas Dehairs, Laurent L'homme, Gaëtan Herinckx, Nathalie Esser, Olivia Jansen, Yvette Habraken, Cédric Lassence, Johan V Swinnen, Mark H Rider, Jacques Piette, Nicolas Paquot, Sylvie Legrand-Poels

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

不饱和脂肪酸可防止人类单核细胞/巨噬细胞中 NLRP3 炎症小体的激活

Laurent L'homme, Nathalie Esser, Laura Riva, André Scheen, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels

The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process

c-Jun N 端激酶 (JNK) 结合蛋白 (JNKBP1) 通过抑制 NOD2 蛋白的寡聚化过程,充当 NOD2 蛋白信号传导的负调节剂

Aurore Lecat, Emmanuel Di Valentin, Joan Somja, Samuel Jourdan, Marianne Fillet, Thomas A Kufer, Yvette Habraken, Catherine Sadzot, Edouard Louis, Philippe Delvenne, Jacques Piette, Sylvie Legrand-Poels

Perturbation of actin dynamics induces NF-kappaB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway

肌动蛋白动力学的扰动通过 NADPH 氧化酶依赖性途径诱导髓单核细胞中 NF-κB 的激活。

Kustermans, Gaelle; El Benna, Jamel; Piette, Jacques; Legrand-Poels, Sylvie