日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer

CB-103（一种首创的转录Notch抑制剂）在乳腺癌临床前模型中的疗效

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers15153957
Vigolo, Michele; Urech, Charlotte; Lamy, Sebastien; Monticone, Giulia; Zabaleta, Jovanny; Hossain, Fokhrul; Wyczechowska, Dorota; Del Valle, Luis; O'Regan, Ruth M; Miele, Lucio; Lehal, Rajwinder; Majumder, Samarpan
肿瘤
肿瘤免疫
乳腺癌
Notch
发表日期：2023
文献求助 收藏

A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors

一项针对晚期腺样囊性癌和其他肿瘤患者的泛Notch抑制剂CB-103的I期研究

期刊:Cancer Research Communications
影响因子:3.3
doi:10.1158/2767-9764.CRC-23-0333
Hanna, Glenn J; Stathis, Anastasios; Lopez-Miranda, Elena; Racca, Fabricio; Quon, Doris; Leyvraz, Serge; Hess, Dagmar; Keam, Bhumsuk; Rodon, Jordi; Ahn, Myung-Ju; Kim, Hye Ryun; Schneeweiss, Andreas; Ribera, Josep-Maria; DeAngelo, Daniel; Perez Garcia, Jose Manuel; Cortes, Javier; Schönborn-Kellenberger, Oliver; Weber, Dirk; Pisa, Pavel; Bauer, Michael; Beni, Laura; Bobadilla, Maria; Lehal, Raj; Vigolo, Michele; Vogl, Florian D; Garralda, Elena
肿瘤
肿瘤免疫
Notch
发表日期：2023
文献求助 收藏

CB-103: A novel CSL-NICD inhibitor for the treatment of NOTCH-driven T-cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T-ALL

CB-103：一种新型CSL-NICD抑制剂，用于治疗NOTCH驱动的T细胞急性淋巴细胞白血病：一例复发难治性T-ALL患者获得完全临床缓解的病例报告

期刊:eJHaem
影响因子:1.2
doi:10.1002/jha2.510
Medinger, Michael; Junker, Till; Heim, Dominik; Tzankov, Alexandar; Jermann, Philip M; Bobadilla, Maria; Vigolo, Michele; Lehal, Rajwinder; Vogl, Florian D; Bauer, Michael; Passweg, Jakob
OTC
T细胞
NOTCH
白血病
T细胞
细胞生物学
免疫/内分泌
发表日期：2022
文献求助 收藏

Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity

将 Notch 抑制剂靶向骨髓瘤骨髓微环境可减少肿瘤生长和骨质破坏，且无肠道毒性

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-21-0524
Hayley M Sabol #, Adam J Ferrari #, Manish Adhikari, Tânia Amorim, Kevin McAndrews, Judith Anderson, Michele Vigolo, Rajwinder Lehal, Meloney Cregor, Sharmin Khan, Pedro L Cuevas, Jill A Helms, Noriyoshi Kurihara, Venkat Srinivasan, Frank H Ebetino, Robert K Boeckman Jr, G David Roodman, Teresita Be
信号转导
肿瘤
骨髓瘤
Notch
发表日期：2021
文献求助 收藏

Fatigability of the external anal sphincter muscles using a novel strength training resistance exercise device

使用新型力量训练阻力运动装置研究外肛门括约肌的疲劳性

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:3.3
doi:10.1152/ajpgi.00456.2020
Mei, Ling; Patel, Krupa; Lehal, Navjit; Kern, Mark K; Benjamin, Adam; Sanvanson, Patrick; Shaker, Reza
发表日期：2021
文献求助 收藏

Differences in fatigability of muscles involved in fecal continence: Potential clinical ramifications

控制排便的肌肉疲劳程度差异：潜在的临床意义

期刊:Physiological Reports
影响因子:1.9
doi:10.14814/phy2.15144
Patel, Krupa; Mei, Ling; Yu, Elliot; Kern, Mark; Lehal, Navjit; Edeani, Francis; Sanvanson, Patrick; Davidson, Emily R W; Shaker, Reza
发表日期：2021
文献求助 收藏

Pharmacological disruption of the Notch transcription factor complex

Notch转录因子复合物的药理学破坏

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1922606117
Lehal, Rajwinder; Zaric, Jelena; Vigolo, Michele; Urech, Charlotte; Frismantas, Viktoras; Zangger, Nadine; Cao, Linlin; Berger, Adeline; Chicote, Irene; Loubéry, Sylvain; Choi, Sung Hee; Koch, Ute; Blacklow, Stephen C; Palmer, Hector G; Bornhauser, Beat; González-Gaitán, Marcos; Arsenijevic, Yvan; Zoete, Vincent; Aster, Jon C; Bourquin, Jean-Pierre; Radtke, Freddy
Notch
发表日期：2020
文献求助 收藏