日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of Pharmacologically Left Shifting the Oxygen-Hemoglobin Dissociation Curve on Arterial Blood Gases and Pulmonary Gas Exchange During Maximal Exercise in Hypoxia

药物左移氧合血红蛋白解离曲线对低氧条件下最大运动期间动脉血气和肺气体交换的影响

Stewart, Glenn M; Cross, Troy J; Joyner, Michael J; Chase, Steven C; Curry, Timothy; Lehrer-Graiwer, Josh; Dufu, Kobina; Vlahakis, Nicholas E; Johnson, Bruce D

GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury.

GBT1118 是一种能提高血红蛋白氧亲和力的化合物,可改善小鼠缺氧性急性肺损伤的存活率

Putz Nathan D, Shaver Ciara M, Dufu Kobina, Li Chien-Ming, Xu Qing, Hutchaleelaha Athiwat, Lehrer-Graiwer Josh, Majka Susan M, Ware Lorraine B, Bastarache Julie A

Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease

沃克洛托(GBT440)对镰状细胞病患者非结合胆红素和黄疸的影响

Telfer, Paul; Agodoa, Irene; Fox, Kathleen M; Burke, Laurie; Mant, Timothy; Jurek, Marzena; Tonda, Margaret; Lehrer-Graiwer, Josh

GBT1118, a potent allosteric modifier of hemoglobin O(2) affinity, increases tolerance to severe hypoxia in mice

GBT1118 是一种强效的血红蛋白氧亲和力变构调节剂,可提高小鼠对严重缺氧的耐受性。

Dufu, Kobina; Yalcin, Ozlem; Ao-Ieong, Eilleen S Y; Hutchaleelala, Athiwat; Xu, Qing; Li, Zhe; Vlahakis, Nicholas; Oksenberg, Donna; Lehrer-Graiwer, Josh; Cabrales, Pedro

Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis

血红蛋白氧亲和力增加可改善博来霉素引起的低氧血症和肺纤维化

Geng, Xin; Dufu, Kobina; Hutchaleelaha, Athiwat; Xu, Qing; Li, Zhe; Li, Chien-Ming; Patel, Mira P; Vlahakis, Nicholas; Lehrer-Graiwer, Josh; Oksenberg, Donna

GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

GBT440 在模拟剧烈运动的体外条件下抑制镰状细胞性状血液的镰状化

Dufu, Kobina; Lehrer-Graiwer, Josh; Ramos, Eleanor; Oksenberg, Donna