日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

可塑性活性位点环是实现高底物混杂性的关键吗?一种具有卓越双重立体控制的结构多样化紫杉烷侧链的混合生物催化途径

Kudalkar, Gaurav P; Leidner, Florian; Kumar, Nivesh; Hass, Jared L; Madzelan, Peter; Powell, Douglas R; Day, Victor W; Magueres, Pierre Le; Ferrara, Joseph D; Daniels, Lee M; Yamano, Akihito; Ito, Sho; Niu, Wei; Grubmüller, Helmut; Wilson, Mark A; Berkowitz, David B

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation

UBE2J2 使 ERAD 泛素化级联反应对膜脂饱和度的变化更加敏感

Vrentzou, Aikaterini; Leidner, Florian; Schmidt, Claudia C; Grubmüller, Helmut; Stein, Alexander

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1.

泛素连接酶 HUWE1 对药物样小分子进行选择性泛素化

Orth Barbara, Pohl Pavel, Aust Florian, Ji Yanlong, Seenivasan Ayshwarya, Dybkov Olexandr, Liang Xiaojun Julia, Bock Lars, Leidner Florian, Levantovsky Sophie, Schardey Patrick, Sander Pascal, Disch Nathanael J, Trautz Masanja L, Mizi Athanasia, Papantonis Argyris, Lenz Christof, Grubmüller Helmut, Steinchen Wieland, Behrends Christian, Urlaub Henning, Gehringer Matthias, Lorenz Sonja

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

听觉毛细胞突触蛋白——耳蛋白的结构和功能

Chen, Han; Cretu, Constantin; Trebilcock, Abigail; Evdokimova, Natalia; Babai, Norbert; Feldmann, Laura; Leidner, Florian; Benseler, Fritz; Mutschall, Sophia; Esch, Klara; Szabo, Csaba Zoltan Kibedi; Pena, Vladimir; Pape, Constantin; Grubmüller, Helmut; Strenzke, Nicola; Brose, Nils; Wichmann, Carolin; Preobraschenski, Julia; Moser, Tobias

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

避免直接抗病毒药物及其他药物产生耐药性的药物设计策略

Matthew, Ashley N; Leidner, Florian; Lockbaum, Gordon J; Henes, Mina; Zephyr, Jacqueto; Hou, Shurong; Rao, Desaboini Nageswara; Timm, Jennifer; Rusere, Linah N; Ragland, Debra A; Paulsen, Janet L; Prachanronarong, Kristina; Soumana, Djade I; Nalivaika, Ellen A; Kurt Yilmaz, Nese; Ali, Akbar; Schiffer, Celia A

Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning

通过耦合分子动力学和机器学习来解析耐药性和效力丧失的复杂机制

Leidner, Florian; Kurt Yilmaz, Nese; Schiffer, Celia A

Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning

利用分子动力学和机器学习解析卡氏肺孢子虫二氢叶酸还原酶的抗真菌药物耐药性

Leidner, Florian; Kurt Yilmaz, Nese; Schiffer, Celia A

Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir

格卡瑞韦抑制泛基因型HCV NS3/4A蛋白酶的分子和结构机制

Timm, Jennifer; Kosovrasti, Klajdi; Henes, Mina; Leidner, Florian; Hou, Shurong; Ali, Akbar; Kurt Yilmaz, Nese; Schiffer, Celia A

Optimizing the refinement of merohedrally twinned P6(1) HIV-1 protease-inhibitor cocrystal structures

优化半面体孪晶P6(1) HIV-1蛋白酶抑制剂共晶体结构的精修

Lockbaum, Gordon J; Leidner, Florian; Royer, William E; Kurt Yilmaz, Nese; Schiffer, Celia A

Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B

人胞苷脱氨酶APOBEC3B活性位点和DNA结合的结构分析

Hou, Shurong; Silvas, Tania V; Leidner, Florian; Nalivaika, Ellen A; Matsuo, Hiroshi; Kurt Yilmaz, Nese; Schiffer, Celia A