日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Programming tumor evolution with selection gene drives to proactively combat drug resistance

利用选择基因驱动程序控制肿瘤进化,以主动对抗耐药性

Scott M Leighow ,Joshua A Reynolds ,Ivan Sokirniy ,Shun Yao ,Zeyu Yang ,Haider Inam ,Dominik Wodarz ,Marco Archetti ,Justin R Pritchard

Characterizing Variants of Uncertain Drug Resistance (VUDRs) Using Quantitative Measurements at Clinical Exposures

利用临床暴露下的定量测量方法表征不确定耐药性变异株(VUDRs)

Inam, Haider; Tomaszkiewicz, Marta; Reynolds, Joshua; Yang, Zeyu; Leighow, Scott; Pritchard, Justin R

Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing

转化研究中激酶抑制剂浓度过高阻碍了有效的药物再利用

Chuan Liu, Scott M Leighow, Kyle McIlroy, Mengrou Lu, Kady A Dennis, Kerry Abello, Donovan J Brown, Connor J Moore, Anushka Shah, Haider Inam, Victor M Rivera, Justin R Pritchard

Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions

揭示全氟烷基-蛋白质相互作用的机制基础

Lawanprasert, Atip; Sloand, Janna N; González Vargas, Mariangely; Singh, Harminder; Eldor, Tomer; Miller, Michael A; Pimcharoen, Sopida; Wang, Jian; Leighow, Scott M; Pritchard, Justin R; Dokholyan, Nikolay V; Medina, Scott H

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

对哺乳动物细胞特异性的泛CRISPR分析鉴定出用于基因组规模实验的超紧凑型sgRNA子集。

Zhao, Boyang; Rao, Yiyun; Leighow, Scott; O'Brien, Edward P; Gilbert, Luke; Pritchard, Justin R

SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics

美国三个州在社会和经济重启后,SARS-CoV-2疫情的年龄结构和临床特征发生了变化。

Wikle, Nathan B; Tran, Thu Nguyen-Anh; Gentilesco, Bethany; Leighow, Scott M; Albert, Emmy; Strong, Emily R; Brinda, Karel; Inam, Haider; Yang, Fuhan; Hossain, Sajid; Chan, Philip; Hanage, William P; Messick, Maria; Pritchard, Justin R; Hanks, Ephraim M; Boni, Maciej F

SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021

2020年3月至2021年5月新英格兰南部SARS-CoV-2感染率和人群免疫力

Tran, Thu Nguyen-Anh; Wikle, Nathan B; Yang, Fuhan; Inam, Haider; Leighow, Scott; Gentilesco, Bethany; Chan, Philip; Albert, Emmy; Strong, Emily R; Pritchard, Justin R; Hanage, William P; Hanks, Ephraim M; Crawford, Forrest W; Boni, Maciej F

Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes

基于代理的模型通过分析不同药物失效模式之间的竞争关系,帮助解释临床药物耐药模式。

Leighow, Scott M; Landry, Ben; Lee, Michael J; Peyton, Shelly R; Pritchard, Justin R

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

利用罗德岛州和马萨诸塞州的实时感染率估计值,实现SARS-CoV-2疫苗的最佳分配

Tran, Thu Nguyen-Anh; Wikle, Nathan B; Albert, Emmy; Inam, Haider; Strong, Emily; Brinda, Karel; Leighow, Scott M; Yang, Fuhan; Hossain, Sajid; Pritchard, Justin R; Chan, Philip; Hanage, William P; Hanks, Ephraim M; Boni, Maciej F

SARS-CoV-2 attack rate and population immunity in southern New England, March 2020 - May 2021

2020年3月至2021年5月,新英格兰南部SARS-CoV-2感染率和人群免疫力

Tran, Thu Nguyen-Anh; Wikle, Nathan B; Yang, Fuhan; Inam, Haider; Leighow, Scott; Gentilesco, Bethany; Chan, Philip; Albert, Emmy; Strong, Emily R; Pritchard, Justin R; Hanage, William P; Hanks, Ephraim M; Crawford, Forrest W; Boni, Maciej F