日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A "one-step" approach to heart rate correction and statistical analysis applied to conscious dog QTc studies

一种应用于清醒犬QTc研究的心率校正和统计分析的“一步法”

Best, Derek D; Abernathy, Matthew M; Leishman, Derek J

The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis

QT 分析的“一步法”提高了非临床 QTc 分析的灵敏度

Leishman, Derek J; Holdsworth, David L; Lauver, D Adam; Bailie, Marc B; Roche, Brian M

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

是时候进行全面整合的非临床-临床风险评估,以简化QT间期延长责任认定流程了:制药行业的视角

Vargas, Hugo M; Rolf, Michael G; Wisialowski, Todd A; Achanzar, William; Bahinski, Anthony; Bass, Alan; Benson, Charles T; Chaudhary, Khuram W; Couvreur, Nicolas; Dota, Corina; Engwall, Michael J; Michael Foley, C; Gallacher, David; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Guth, Brian; Himmel, Herbert M; Hegele-Hartung, Christa; Ito, Maki; Jenkinson, Stephen; Chiba, Katsuyoshi; Lagrutta, Armando; Levesque, Paul; Martel, Eric; Okai, Yoshiko; Peri, Ravikumar; Pointon, Amy; Qu, Yusheng; Teisman, Ard; Traebert, Martin; Yoshinaga, Takashi; Gintant, Gary A; Leishman, Derek J; Valentin, Jean-Pierre

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

心律失常风险预测模型验证的一般原则:CiPA 计算机模拟策略的扩展

Li, Zhihua; Mirams, Gary R; Yoshinaga, Takashi; Ridder, Bradley J; Han, Xiaomei; Chen, Janell E; Stockbridge, Norman L; Wisialowski, Todd A; Damiano, Bruce; Severi, Stefano; Morissette, Pierre; Kowey, Peter R; Holbrook, Mark; Smith, Godfrey; Rasmusson, Randall L; Liu, Michael; Song, Zhen; Qu, Zhilin; Leishman, Derek J; Steidl-Nichols, Jill; Rodriguez, Blanca; Bueno-Orovio, Alfonso; Zhou, Xin; Passini, Elisa; Edwards, Andrew G; Morotti, Stefano; Ni, Haibo; Grandi, Eleonora; Clancy, Colleen E; Vandenberg, Jamie; Hill, Adam; Nakamura, Mikiko; Singer, Thomas; Polonchuk, Liudmila; Greiter-Wilke, Andrea; Wang, Ken; Nave, Stephane; Fullerton, Aaron; Sobie, Eric A; Paci, Michelangelo; Musuamba Tshinanu, Flora; Strauss, David G

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua