日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

5' DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5' UTR of Target Genes

5' DREDGE：通过靶基因的5' UTR直接利用重复序列下调基因表达

期刊:Cells
影响因子:5.2
doi:10.3390/cells14120866
Parikh, Sagar J; Terron, Heather M; Burgard, Luke A; Butler, Dylan D; LaFerla, Frank M; Lane, Shelley; Leissring, Malcolm A
RED
发表日期：2025
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Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases

利用CRISPR相关核糖核酸内切酶进行基因表达靶向控制

期刊:Cells
影响因子:5.2
doi:10.3390/cells14070543
Parikh, Sagar J; Terron, Heather M; Burgard, Luke A; Maranan, Derek S; Butler, Dylan D; Wiseman, Abigail; LaFerla, Frank M; Lane, Shelley; Leissring, Malcolm A
发表日期：2025
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Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation

更正：小鼠胰岛α细胞中胰岛素降解酶的缺失会引发细胞增殖、增生和胰高血糖素分泌失调

期刊:Diabetologia
影响因子:10.2
doi:10.1007/s00125-023-06037-9
Merino, Beatriz; Casanueva-Álvarez, Elena; Quesada, Iván; González-Casimiro, Carlos M; Fernández-Díaz, Cristina M; Postigo-Casado, Tamara; Leissring, Malcolm A; Kaestner, Klaus H; Perdomo, Germán; Cózar-Castellano, Irene
细胞生物学
免疫/内分泌
发表日期：2024
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Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation

小鼠胰岛α细胞中胰岛素降解酶的缺失会引发细胞增殖、增生和胰高血糖素分泌失调。

期刊:Diabetologia
影响因子:10.2
doi:10.1007/s00125-022-05729-y
Merino, Beatriz; Casanueva-Álvarez, Elena; Quesada, Iván; González-Casimiro, Carlos M; Fernández-Díaz, Cristina M; Postigo-Casado, Tamara; Leissring, Malcolm A; Kaestner, Klaus H; Perdomo, Germán; Cózar-Castellano, Irene
细胞生物学
免疫/内分泌
发表日期：2022
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Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme

羟基吡啶硫酮类人胰岛素降解酶抑制剂

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202100111
Adamek, Rebecca N; Suire, Caitlin N; Stokes, Ryjul W; Brizuela, Monica K; Cohen, Seth M; Leissring, Malcolm A
Human
免疫/内分泌
发表日期：2021
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Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin

用于定量、高通量检测胰淀素蛋白水解降解的方法

期刊:Methods and Protocols
影响因子:2
doi:10.3390/mps3040081
Suire, Caitlin N; Brizuela, Monica K; Leissring, Malcolm A
发表日期：2020
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Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

小鼠肝脏特异性敲除胰岛素降解酶会导致肝脏胰岛素抵抗和葡萄糖耐受不良，但不影响胰岛素清除率。

期刊:Metabolism-Clinical and Experimental
影响因子:11.9
doi:10.1016/j.metabol.2018.08.001
Villa-Pérez, Pablo; Merino, Beatriz; Fernández-Díaz, Cristina M; Cidad, Pilar; Lobatón, Carmen D; Moreno, Alfredo; Muturi, Harrison T; Ghadieh, Hilda E; Najjar, Sonia M; Leissring, Malcolm A; Cózar-Castellano, Irene; Perdomo, Germán
代谢
免疫/内分泌
发表日期：2018
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Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease

Aβ降解蛋白酶：在阿尔茨海默病治疗中的潜力

期刊:CNS Drugs
影响因子:7.4
doi:10.1007/s40263-016-0364-1
Leissring, Malcolm A
阿尔茨海默症
发表日期：2016
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Age and its association with low insulin and high amyloid-β peptides in blood

年龄及其与血液中低胰岛素和高β-淀粉样蛋白肽的关系

期刊:Journal of Alzheimers Disease
影响因子:3.1
doi:10.3233/JAD-150428
Li, Huajie; Zhu, Haihao; Wallack, Max; Mwamburi, Mkaya; Abdul-Hay, Samer O; Leissring, Malcolm A; Qiu, Wei Qiao
免疫/内分泌
发表日期：2016
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Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

利用准不可逆硫醇修饰抑制剂选择性靶向细胞外胰岛素降解酶

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.5b00334
Abdul-Hay, Samer O; Bannister, Thomas D; Wang, Hui; Cameron, Michael D; Caulfield, Thomas R; Masson, Amandine; Bertrand, Juliette; Howard, Erin A; McGuire, Michael P; Crisafulli, Umberto; Rosenberry, Terrone R; Topper, Caitlyn L; Thompson, Caroline R; Schürer, Stephan C; Madoux, Franck; Hodder, Peter; Leissring, Malcolm A
细胞生物学
免疫/内分泌
发表日期：2015
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