日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice

在给予烟草致癌物NNK之前口服二氢甲基噻菌灵可有效预防A/J小鼠肺部肿瘤的发生

期刊:Chemical Research in Toxicology
影响因子:3.8
doi:10.1021/acs.chemrestox.0c00161
Hu, Qi; Corral, Pedro; Narayanapillai, Sreekanth C; Leitzman, Pablo; Upadhyaya, Pramod; O'Sullivan, M Gerard; Hecht, Stephen S; Lu, Junxuan; Xing, Chengguo
肿瘤
肿瘤免疫
发表日期：2020
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Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O(6)-Methylguanine and Lung Tumor in A/J Mice

二氢甲基霉素在阻断4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁酮诱导的A/J小鼠O(6)-甲基鸟嘌呤和肺肿瘤中的体内构效关系初步研究

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.7b00921
Puppala, Manohar; Narayanapillai, Sreekanth C; Leitzman, Pablo; Sun, Haifeng; Upadhyaya, Pramod; O'Sullivan, M Gerard; Hecht, Stephen S; Xing, Chengguo
肿瘤
肿瘤免疫
发表日期：2017
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Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

膳食二氢甲胆碱可增加 A/J 小鼠中 4-(甲基亚硝氨基)-1-(3-吡啶基)-1-丁醇的葡萄糖醛酸化，从而可能增强其解毒作用

期刊:Drug Metabolism and Disposition
影响因子:4.4
doi:10.1124/dmd.115.068387
Sreekanth C Narayanapillai, Linda B von Weymarn, Steven G Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S Hecht, Sharon E Murphy, Chengguo Xing
发表日期：2016
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Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice

二氢甲基丁酸 (DHM) 以不依赖芳基烃受体 (AhR) 通路的方式阻断烟草致癌物 4-(甲基亚硝氨基)-1-(3-吡啶基)-1-丁酮 (NNK) 诱导的 O6-甲基鸟嘌呤

期刊:Chemical Research in Toxicology
影响因子:3.7
doi:10.1021/acs.chemrestox.6b00203
Sreekanth C Narayanapillai, Shang-Hsuan Lin, Pablo Leitzman, Pramod Upadhyaya, Carolyn J Baglole, Chengguo Xing
肿瘤
发表日期：2016
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Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone-rich Kava fraction

富含卡瓦内酯的卡瓦提取物抑制TRAMP前列腺癌发生的基因表达特征

期刊:Molecular Carcinogenesis
影响因子:3.2
doi:10.1002/mc.22469
Tang, Su-Ni; Zhang, Jinhui; Jiang, Peixin; Datta, Palika; Leitzman, Pablo; O'Sullivan, M Gerard; Jiang, Cheng; Xing, Chengguo; Lü, Junxuan
肿瘤
前列腺癌
肿瘤免疫
发表日期：2016
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Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice

卡瓦胡椒中的黄酮卡瓦因a和B（而非二氢甲氧基卡瓦因）可增强对乙酰氨基酚诱导的C57BL/6小鼠肝毒性。

期刊:Chemical Research in Toxicology
影响因子:3.8
doi:10.1021/tx5003194
Narayanapillai, Sreekanth C; Leitzman, Pablo; O'Sullivan, M Gerard; Xing, Chengguo
毒理研究
发表日期：2014
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Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

卡瓦胡椒中的二氢甲基异噻唑啉酮可阻断烟草致癌物4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮诱导的肺肿瘤发生，并能差异性地减少A/J小鼠的DNA损伤。

期刊:Carcinogenesis
影响因子:2.9
doi:10.1093/carcin/bgu149
Narayanapillai, Sreekanth C; Balbo, Silvia; Leitzman, Pablo; Grill, Alex E; Upadhyaya, Pramod; Shaik, Ahmad Ali; Zhou, Bo; O'Sullivan, M Gerard; Peterson, Lisa A; Lu, Junxuan; Hecht, Stephen S; Xing, Chengguo
毒理研究
肿瘤
肿瘤免疫
发表日期：2014
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Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice

卡瓦胡椒通过减少A/J小鼠体内O6-甲基鸟嘌呤DNA加合物，抑制4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮诱导的肺肿瘤发生。

期刊:Cancer Prevention Research
影响因子:2.6
doi:10.1158/1940-6207.CAPR-13-0301
Leitzman, Pablo; Narayanapillai, Sreekanth C; Balbo, Silvia; Zhou, Bo; Upadhyaya, Pramod; Shaik, Ahmad Ali; O'Sullivan, M Gerard; Hecht, Stephen S; Lu, Junxuan; Xing, Chengguo
肿瘤
肿瘤免疫
发表日期：2014
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