日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of PLCγ2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCγ2激活剂

Hawksley, J C; Clayton, Brent; Massey, Steven M; Chu, Shaoyou; Mason, Emily R; Bissel, Stephanie J; Bedford, Logan M; Rizzo, Stacey J Sukoff; Mesecar, Andrew D; Kaiser, Bridget L; Lendy, Emma K; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors

探索尼尔马特雷韦的P1和P4修饰:SARS-CoV-2 Mpro抑制剂的设计、合成、生物学评价和X射线结构研究

Ghosh, Arun K; Yadav, Monika; Iddum, Satyanarayana; Ghazi, Somayeh; Lendy, Emma K; Jayashankar, Uttara; Beechboard, Sydney N; Takamatsu, Yuki; Hattori, Shin-Ichiro; Amano, Masayuki; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D

Identification of PLCG2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCG2激活剂

Dang, Lei; Zhang, Chunbo; Su, Biru; Ning, Na; Huang, Qiuling; Zhou, Su; Wu, Meng; Ma, Wenqing; Wang, Man; Cui, Pengfei; Li, Yan; Wang, Shixuan; Clayton, Brent; Massey, Steven M; Beck, Daniel E; Putt, Karson S; Utsuki, Tada; Visvanathan, Ramya; Mesecar, Andrew D; Lendy, Emma K; Kaiser, Bridget L; Chu, Shaoyou; Mason, Emily R; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Development of a sensitive microplate assay for characterizing RNA methyltransferase activity: Implications for epitranscriptomics and drug development.

开发一种灵敏的微孔板检测方法来表征 RNA 甲基转移酶活性:对表观转录组学和药物开发的影响

Mensah Isaiah K, Norvil Allison B, He Ming, Lendy Emma, Hjortland Nicole, Tan Hern, Pomerantz Richard T, Mesecar Andrew, Gowher Humaira

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

非甾体抗炎药的氯吡啶酯及其相关衍生物作为强效SARS-CoV-2 3CL蛋白酶抑制剂

Ghosh, Arun K; Shahabi, Dana; Yadav, Monika; Kovela, Satish; Anson, Brandon J; Lendy, Emma K; Bonham, Connie; Sirohi, Devika; Brito-Sierra, Carlos A; Hattori, Shin-Ichiro; Kuhn, Richard; Mitsuya, Hiroaki; Mesecar, Andrew D

Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies

高选择性和高效性人β-分泌酶2 (BACE2) 抑制剂治疗2型糖尿病:设计、合成、X射线结构和构效关系研究

Ghosh, Arun K; Brindisi, Margherita; Yen, Yu-Chen; Lendy, Emma K; Kovela, Satish; Cárdenas, Emilio Leal; Reddy, Bhavanam Sekhara; Rao, Kalapala Venketeswara; Downs, Deborah; Huang, Xiangping; Tang, Jordan; Mesecar, Andrew D

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

以双环异噁唑啉甲酰胺为P3配体的新型BACE1抑制剂的设计、合成、X射线研究和生物学评价

Ghosh, Arun K; Ghosh, Koena; Brindisi, Margherita; Lendy, Emma K; Yen, Yu-Chen; Kumaragurubaran, Nagaswamy; Huang, Xiangping; Tang, Jordan; Mesecar, Andrew D