文献库，生知库 | 链接生命科学的每一步

Yang, Zhengning; Meng, Zhongxuan; Liu, Shangyuan; Chen, Yuxin; Gan, Xuhong; Zhang, Zi-Mei; Luo, Xiaoshan; Yan, Jiahong; Chen, Huijin; Huang, Danqing; Huang, Lihong; Zeng, Xiaomin; Ma, Wenyu; Liu, Jun; Wang, Linlin; Huang, Haotian; Yang, Xinyi; Hu, Mei; Chen, Lin; Du, Hongli; Leng, Qibin; Qiu, Li; Wang, Xiaoling

肿瘤

肿瘤免疫

信号转导

In situ DC-primed vaccine combined with CD137 agonist elicits long-lasting antitumor immunity through cDC1-mediated tumor antigen-specific CD8(+) T cell responses

原位DC启动的疫苗联合CD137激动剂可通过cDC1介导的肿瘤抗原特异性CD8(+) T细胞反应诱导持久的抗肿瘤免疫。

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-011665

Wang, Mengjiao; Qiu, Li; Tang, Cheng; Huang, Danqing; Zheng, Qiaocong; Li, Zunyi; Zhang, Zhenhui; Wei, Shupei; Chen, Lanfang; Huang, Hongxin; Liu, Jun; Zhou, Junfeng; Lu, Tao; Liu, Guanxin; Nie, Yingjie; Leng, Qibin; Chen, Tao

Prognostic value of diffusion-weighted imaging to cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for patients with gastric cancer and peritoneal metastases

弥散加权成像对接受或不接受腹腔热灌注化疗的胃癌腹膜转移患者进行细胞减灭术的预后价值

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-025-14008-z

Xin, Xin; Tang, Yongfang; Lu, Man; Huang, Jie; Shang, Jian; Yang, Lidan; Dai, Lihuan; Yin, Jinxue; Li, Jiansheng; Leng, Qibin; Tang, Hongsheng; Zhong, Xi

Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

单细胞分析揭示人类结直肠癌的抑制性肿瘤微环境

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.422

Mei, Yan; Xiao, Weiwei; Hu, Hao; Lu, Guanming; Chen, Lingdan; Sun, Zhun; Lü, Mengdie; Ma, Wenhui; Jiang, Ting; Gao, YuanHong; Li, LiRen; Chen, Gong; Wang, Zifeng; Li, Hanjie; Wu, Duojiao; Zhou, Pinghong; Leng, Qibin; Jia, Guangshuai

Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell Immunity

全球范围内的抗原进化揭示了预先存在的交叉反应性T细胞免疫对严重急性呼吸综合征冠状病毒2的潜在自然选择作用

期刊:Frontiers in Microbiology

影响因子:4.5

doi:10.3389/fmicb.2021.599562

Zhang, Chengdong; Jin, Xuanxuan; Chen, Xianyang; Qiu, Li; Leng, Qibin; Qiu, Tianyi

Strong immunity against COVID-19 in the early two years of age links to frequent immunization of routine vaccines

两岁左右儿童对新冠病毒的强免疫力与频繁接种常规疫苗有关。

期刊:Science Bulletin

影响因子:21.1

doi:10.1016/j.scib.2020.08.012

Qiu, Li; Zhang, Chengdong; Wu, Junbo; Luo, Jie; Netea, Mihai G; Luo, Zhiguo; Leng, Qibin

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

肠道上皮细胞TSC1/mTOR调控肠道炎症和癌症中的RIPK3依赖性坏死性凋亡

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI133264

Xie, Yadong; Zhao, Yifan; Shi, Lei; Li, Wei; Chen, Kun; Li, Min; Chen, Xia; Zhang, Haiwei; Li, Tiantian; Matsuzawa-Ishimoto, Yu; Yao, Xiaomin; Shao, Dianhui; Ke, Zunfu; Li, Jian; Chen, Yan; Zhang, Xiaoming; Cui, Jun; Cui, Shuzhong; Leng, Qibin; Cadwell, Ken; Li, Xiaoxia; Wei, Hong; Zhang, Haibing; Li, Huabin; Xiao, Hui

Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung Injury

二甲双胍的免疫调节和抗病毒活性及其在治疗2019冠状病毒病和肺损伤中的潜在意义

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2020.02056

Chen, Xianyang; Guo, Huifang; Qiu, Li; Zhang, Chengdong; Deng, Qiang; Leng, Qibin

Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2

ACE2 和 TMPRSS2 的单细胞表达谱揭示了 SARS-CoV-2 潜在的垂直传播和胎儿感染。

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.104015

Lü, Mengdie; Qiu, Li; Jia, Guangshuai; Guo, Rongqun; Leng, Qibin

Pre-existing heterologous T-cell immunity and neoantigen immunogenicity

预先存在的异源性T细胞免疫和新抗原免疫原性

期刊:Clinical & Translational Immunology

影响因子:3.8

doi:10.1002/cti2.1111

Leng, Qibin; Tarbe, Marion; Long, Qi; Wang, Feng

LTO1 and YAE1 regulate MHC-I expression via nonsense-mediated RNA decay in tumor cells

LTO1和YAE1通过无义介导的RNA降解调控肿瘤细胞中MHC-I的表达。

In situ DC-primed vaccine combined with CD137 agonist elicits long-lasting antitumor immunity through cDC1-mediated tumor antigen-specific CD8(+) T cell responses

原位DC启动的疫苗联合CD137激动剂可通过cDC1介导的肿瘤抗原特异性CD8(+) T细胞反应诱导持久的抗肿瘤免疫。

Prognostic value of diffusion-weighted imaging to cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for patients with gastric cancer and peritoneal metastases

弥散加权成像对接受或不接受腹腔热灌注化疗的胃癌腹膜转移患者进行细胞减灭术的预后价值

Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

单细胞分析揭示人类结直肠癌的抑制性肿瘤微环境

Antigenic Evolution on a Global Scale Reveals the Potential Natural Selection of Severe Acute Respiratory Syndrome-Coronavirus 2 by Pre-existing Cross-Reactive T-Cell Immunity

全球范围内的抗原进化揭示了预先存在的交叉反应性T细胞免疫对严重急性呼吸综合征冠状病毒2的潜在自然选择作用

Strong immunity against COVID-19 in the early two years of age links to frequent immunization of routine vaccines

两岁左右儿童对新冠病毒的强免疫力与频繁接种常规疫苗有关。

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

肠道上皮细胞TSC1/mTOR调控肠道炎症和癌症中的RIPK3依赖性坏死性凋亡

Immunomodulatory and Antiviral Activity of Metformin and Its Potential Implications in Treating Coronavirus Disease 2019 and Lung Injury

二甲双胍的免疫调节和抗病毒活性及其在治疗2019冠状病毒病和肺损伤中的潜在意义

Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2

ACE2 和 TMPRSS2 的单细胞表达谱揭示了 SARS-CoV-2 潜在的垂直传播和胎儿感染。

Pre-existing heterologous T-cell immunity and neoantigen immunogenicity

预先存在的异源性T细胞免疫和新抗原免疫原性