CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination
CD47通过稳定ROBO2来调节胶质母细胞瘤的进展,其机制是通过阻止ITCH介导的泛素化。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2602460123
Polara, Ruhi; Gliddon, Briony L; Ganesan, Raja; Davies, Lorena T; Toubia, John; Lenin, Sakthi; Siddiqui, Ghizal; Morris-Hanon, Olivia; Tea, Melinda N; Moretti, Paul A B; Nguyen, Dung A; Kok, Chung Hoow; Shard, Chloe; Staudacher, Alexander H; Brown, Michael P; Creek, Darren J; Gomez, Guillermo A; Thomas, Daniel; Pitson, Stuart M; Robinson, Nirmal
ROBO2
表观遗传
T细胞
CD47
泛素化
ITCH
细胞生物学
CD4