日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Preclinical signal for a disease-modifying effect on seizure cluster severity with intermittent diazepam treatment

间歇性地西泮治疗对癫痫发作簇严重程度具有疾病改善作用的临床前信号

期刊:Epilepsia
影响因子:6.6
doi:10.1002/epi.70051
Wu, Qian; Guignet, Michelle; Vuong, Jonathan; White, H Steve; Kerr, Wesley T; Shih, Evelyn K; Ngo, Leock Y; Carrazana, Enrique; Rabinowicz, Adrian L
信号转导
癫痫
神经科学
发表日期：2026
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Efficacy and safety of perampanel as first adjunctive therapy in patients with focal-onset seizures or generalized tonic-clonic seizures in four post-marketing studies across regions

四项上市后研究评估了吡仑帕奈作为一线辅助疗法治疗局灶性发作或全身强直-阵挛性发作患者的疗效和安全性。

期刊:Epilepsia Open
影响因子:2.9
doi:10.1002/epi4.70183
Meletti, Stefano; Punia, Vineet; Dash, Amitabh; Gentile, Anna Lisa; Sáinz-Fuertes, Ricardo; Goldman, Samantha; Goldmann, Tobias; Patten, Anna; Kumar, Dinesh; Ngo, Leock Y; Steinhoff, Bernhard J
强直性脊柱炎
发表日期：2026
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Safety, Tolerability, and Pharmacokinetics of NRL-1049, a Rho-Associated Kinase Inhibitor, in Healthy Volunteers: A Phase 1, First-in-Human, Single-Ascending Dose, Randomized, Placebo-Controlled Trial

NRL-1049（一种 Rho 相关激酶抑制剂）在健康志愿者中的安全性、耐受性和药代动力学：一项 1 期、首次人体、单次递增剂量、随机、安慰剂对照试验

期刊:CNS Drugs
影响因子:7.4
doi:10.1007/s40263-025-01198-0
Madden, Stuart; Awad, Issam; Lopez-Toledano, Miguel A; Morrison, Leslie; Gutierrez, Juan; Ngo, Leock Y; Carrazana, Enrique; Rabinowicz, Adrian L
信号转导
Human
发表日期：2025
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Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of focal seizures

随机分组前癫痫发作计数设计充分评估了吡仑帕奈治疗局灶性癫痫的安全性和耐受性。

期刊:Epilepsia
影响因子:6.6
doi:10.1111/epi.18460
Kerr, Wesley T; Ngo, Leock Y; Zhu, Liang; Patten, Anna; Cheng, Jocelyn Y; Biju, Lavanya; French, Jacqueline A
癫痫
神经科学
发表日期：2025
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Efficacy and safety of perampanel in patients with seizures associated with Lennox-Gastaut syndrome: A randomized trial

吡仑帕奈治疗Lennox-Gastaut综合征相关癫痫患者的疗效和安全性：一项随机试验

期刊:Epilepsia
影响因子:6.6
doi:10.1111/epi.18193
Vossler, David G; Porter, Brenda E; Kira, Ryutaro; Lee, Jeehun; Aeby, Alec; Patten, Anna; Cheng, Jocelyn Y; Ngo, Leock Y
癫痫
神经科学
发表日期：2025
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Pharmacokinetics and 180-day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2-5 years

地西泮鼻喷雾剂在2-5岁癫痫患儿中的药代动力学和180天安全性研究

期刊:Epilepsia
影响因子:6.6
doi:10.1111/epi.18473
Segal, Eric B; Wheless, James W; Zafar, Muhammad; Shih, Evelyn K; Ngo, Leock Y; Carrazana, Enrique; Rabinowicz, Adrian L
癫痫
神经科学
发表日期：2025
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Potential for Therapeutic Alteration of the Underlying Biology of Epilepsy

癫痫潜在生物学机制的治疗性改变

期刊:Biomedicines
影响因子:3.9
doi:10.3390/biomedicines13092258
Sperling, Michael R; Peters, Jurriaan M; Wu, Qian; Guignet, Michelle; White, H Steve; Shih, Evelyn K; Ngo, Leock Y; Carrazana, Enrique; Rabinowicz, Adrian L
癫痫
神经科学
发表日期：2025
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Real-world use of adjunctive perampanel for focal-onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)

意大利辅助使用吡仑帕奈治疗局灶性癫痫的真实世界应用：一项针对成人和青少年吡仑帕奈的镜像临床实践研究 (AMPA)

期刊:Epilepsia Open
影响因子:2.9
doi:10.1002/epi4.70068
D'Aniello, Alfredo; Giallonardo, Anna Teresa; Tinuper, Paolo; Mecarelli, Oriano; Aguglia, Umberto; Assenza, Giovanni; Gambardella, Antonio; Canevini, Maria Paola; Scifo, Renato; Meletti, Stefano; De Giorgis, Valentina; Bonanni, Enrica; Michelucci, Roberto; Cerminara, Caterina; Romeo, Antonino; Vigevano, Federico; Operto, Francesca Felicia; Tramacere, Luciana; Di Gennaro, Giancarlo; Ngo, Leock Y; Patten, Anna; Gentile, Anna Lisa; Pecori, Andrea; Goldman, Samantha
癫痫
神经科学
发表日期：2025
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Long-term efficacy and safety of perampanel in patients aged 60 years and older with focal seizures: Post hoc analysis of phase III open-label extension studies stratified by enzyme-inducing anti-seizure medication use

帕拉帕尼治疗60岁及以上局灶性癫痫患者的长期疗效和安全性：按酶诱导型抗癫痫药物使用情况分层的III期开放标签扩展研究的事后分析

期刊:Epilepsy and Behavior Reports
影响因子:1.5
doi:10.1016/j.ebr.2025.100833
Marawar, Rohit; Leppik, Ilo E; Wechsler, Robert T; Patten, Anna; Ngo, Leock Y
癫痫
神经科学
发表日期：2025
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Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of primary generalized tonic-clonic seizures

随机分组前癫痫发作计数设计充分评估了吡仑帕奈治疗原发性全身强直-阵挛性癫痫的安全性和耐受性。

期刊:Epilepsia
影响因子:6.6
doi:10.1111/epi.18023
Kerr, Wesley T; Ngo, Leock Y; Zhu, Liang; Patten, Anna; Cheng, Jocelyn Y; Reddy, Advith S; French, Jacqueline A
强直性脊柱炎
癫痫
神经科学
发表日期：2024
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