日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

QRICH1 mediates an intracellular checkpoint for CD8(+) T cell activation via the CARD11 signalosome.

QRICH1 通过 CARD11 信号体介导 CD8(+) T 细胞活化的细胞内检查点

Carter Nicole M, Hankore Wihib D, Yang Yong-Kang, Yang Chao, Hutcherson Shelby M, Fales Wyatt, Ghosh Anushka, Mongia Piyusha, Mackinnon Sophie, Brennan Anna, Leone Robert D, Pomerantz Joel L

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

发现肿瘤靶向代谢抑制剂前药DRP-104

Rais, Rana; Lemberg, Kathryn M; Tenora, Lukáš; Arwood, Matthew L; Pal, Arindom; Alt, Jesse; Wu, Ying; Lam, Jenny; Aguilar, Joanna Marie H; Zhao, Liang; Peters, Diane E; Tallon, Carolyn; Pandey, Rajeev; Thomas, Ajit G; Dash, Ranjeet P; Seiwert, Tanguy; Majer, Pavel; Leone, Robert D; Powell, Jonathan D; Slusher, Barbara S

Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

癌症免疫疗法中腺苷通路抑制的临床转化下一步

Augustin, Ryan C; Leone, Robert D; Naing, Aung; Fong, Lawrence; Bao, Riyue; Luke, Jason J

Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy

推动变革:靶向代谢以增强免疫疗法

Leone, Robert D; Powell, Jonathan D

Metabolism of immune cells in cancer

癌症中免疫细胞的代谢

Leone, Robert D; Powell, Jonathan D

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

靶向谷氨酰胺代谢可通过调节抑制性髓系细胞来增强肿瘤特异性免疫。

Oh, Min-Hee; Sun, Im-Hong; Zhao, Liang; Leone, Robert D; Sun, Im-Meng; Xu, Wei; Collins, Samuel L; Tam, Ada J; Blosser, Richard L; Patel, Chirag H; Englert, Judson M; Arwood, Matthew L; Wen, Jiayu; Chan-Li, Yee; Tenora, Lukáš; Majer, Pavel; Rais, Rana; Slusher, Barbara S; Horton, Maureen R; Powell, Jonathan D

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

谷氨酰胺阻断诱导不同的代谢程序以克服肿瘤免疫逃逸

Leone, Robert D; Zhao, Liang; Englert, Judson M; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Arwood, Matthew L; Bettencourt, Ian A; Patel, Chirag H; Wen, Jiayu; Tam, Ada; Blosser, Richard L; Prchalova, Eva; Alt, Jesse; Rais, Rana; Slusher, Barbara S; Powell, Jonathan D

Targeting adenosine for cancer immunotherapy

以腺苷为靶点的癌症免疫疗法

Leone, Robert D; Emens, Leisha A

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

抑制腺苷A2a受体可调节T细胞共抑制受体的表达,并改善效应功能,从而增强小鼠癌症模型中的免疫检查点阻断和过继性细胞疗法(ACT)。

Leone, Robert D; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Wen, Jiayu; Englert, Judson; Powell, Jonathan D

Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy

空气中的某种东西:通过高氧环境调节肿瘤微环境以增强免疫疗法

Leone, Robert D; Horton, Maureen R; Powell, Jonathan D