日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Benchmarking Alzheimer's disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies

阿尔茨海默病预测基准测试:利用多基因风险评分,结合多种方法和全基因组研究进行个性化风险评估

Bellou, Eftychia; Kim, Woori; Leonenko, Ganna; Tao, Feifei; Simmonds, Emily; Wu, Ying; Mattsson-Carlgren, Niklas; Hansson, Oskar; Nagle, Michael W; Escott-Price, Valentina

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource.

利用人类 iPSC 模拟具有高低多基因风险的常见阿尔茨海默病:大规模研究资源

Maguire Emily, Winston Jincy, Ellwood Sarah H, O'Donoghue Rachel, Shaw Bethany, Morales Atahualpa Castillo, Keat Samuel, Evans Alexandra, Marshall Rachel, Luckcuck Lauren, Brown Laura, Salis Elisa, Leonenko Ganna, Denning Nicola, Allen Nicholas D, Escott-Price Valentina, Webber Caleb, Taylor Philip R, Sims Rebecca, Cowley Sally A, Williams Julie, Carpanini Sarah M, Hall-Roberts Hazel

Dementias Platform UK: Bringing genetics into life

英国痴呆症平台:将基因学融入生活

Leonenko, Ganna; Bauermeister, Sarah; Ghanti, Dipanwita; Stevenson-Hoare, Joshua; Simmonds, Emily; Brookes, Keeley; Morgan, Kevin; Chaturvedi, Nishi; Elliott, Paul; Thomas, Alan; Wareham, Nicholas; Gallacher, John; Escott-Price, Valentina

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

全基因组分析揭示了MAPT、MOBP和APOE基因位点在散发性额颞叶痴呆症中的潜在作用

Manzoni, Claudia; Kia, Demis A; Ferrari, Raffaele; Leonenko, Ganna; Costa, Beatrice; Saba, Valentina; Jabbari, Edwin; Tan, Manuela Mx; Albani, Diego; Alvarez, Victoria; Alvarez, Ignacio; Andreassen, Ole A; Angiolillo, Antonella; Arighi, Andrea; Baker, Matt; Benussi, Luisa; Bessi, Valentina; Binetti, Giuliano; Blackburn, Daniel J; Boada, Merce; Boeve, Bradley F; Borrego-Ecija, Sergi; Borroni, Barbara; Bråthen, Geir; Brooks, William S; Bruni, Amalia C; Caroppo, Paola; Bandres-Ciga, Sara; Clarimon, Jordi; Colao, Rosanna; Cruchaga, Carlos; Danek, Adrian; de Boer, Sterre Cm; de Rojas, Itziar; di Costanzo, Alfonso; Dickson, Dennis W; Diehl-Schmid, Janine; Dobson-Stone, Carol; Dols-Icardo, Oriol; Donizetti, Aldo; Dopper, Elise; Durante, Elisabetta; Ferrari, Camilla; Forloni, Gianluigi; Frangipane, Francesca; Fratiglioni, Laura; Kramberger, Milica G; Galimberti, Daniela; Gallucci, Maurizio; García-González, Pablo; Ghidoni, Roberta; Giaccone, Giorgio; Graff, Caroline; Graff-Radford, Neill R; Grafman, Jordan; Halliday, Glenda M; Hernandez, Dena G; Hjermind, Lena E; Hodges, John R; Holloway, Guy; Huey, Edward D; Illán-Gala, Ignacio; Josephs, Keith A; Knopman, David S; Kristiansen, Mark; Kwok, John B; Leber, Isabelle; Leonard, Hampton L; Libri, Ilenia; Lleo, Alberto; Mackenzie, Ian R; Madhan, Gaganjit K; Maletta, Raffaele; Marquié, Marta; Maver, Ales; Menendez-Gonzalez, Manuel; Milan, Graziella; Miller, Bruce L; Morris, Christopher M; Morris, Huw R; Nacmias, Benedetta; Newton, Judith; Nielsen, Jørgen E; Nilsson, Christer; Novelli, Valeria; Padovani, Alessandro; Pal, Suvankar; Pasquier, Florence; Pastor, Pau; Perneczky, Robert; Peterlin, Borut; Petersen, Ronald C; Piguet, Olivier; Pijnenburg, Yolande Al; Puca, Annibale A; Rademakers, Rosa; Rainero, Innocenzo; Reus, Lianne M; Richardson, Anna Mt; Riemenschneider, Matthias; Rogaeva, Ekaterina; Rogelj, Boris; Rollinson, Sara; Rosen, Howard; Rossi, Giacomina; Rowe, James B; Rubino, Elisa; Ruiz, Agustin; Salvi, Erika; Sanchez-Valle, Raquel; Sando, Sigrid Botne; Santillo, Alexander F; Saxon, Jennifer A; Schlachetzki, Johannes Cm; Scholz, Sonja W; Seelaar, Harro; Seeley, William W; Serpente, Maria; Sorbi, Sandro; Sordon, Sabrina; St George-Hyslop, Peter; Thompson, Jennifer C; Van Broeckhoven, Christine; Van Deerlin, Vivianna M; Van der Lee, Sven J; Van Swieten, John; Tagliavini, Fabrizio; van der Zee, Julie; Veronesi, Arianna; Vitale, Emilia; Waldo, Maria Landqvist; Yokoyama, Jennifer S; Nalls, Mike A; Momeni, Parastoo; Singleton, Andrew B; Hardy, John; Escott-Price, Valentina

Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population

在欧洲人群中,针对经病理学确诊的阿尔茨海默病病例对照研究,开展X染色体全基因组关联研究

Simmonds, Emily; Leonenko, Ganna; Yaman, Umran; Bellou, Eftychia; Myers, Amanda; Morgan, Kevin; Brookes, Keeley; Hardy, John; Salih, Dervis; Escott-Price, Valentina

P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity

P2RX7 缺陷通过抑制细胞外囊泡分泌和线粒体毒性,阻止 PS19 小鼠出现认知缺陷、脑萎缩和 tau 蛋白病变进展。

Baker, Emily; Leonenko, Ganna; Schmidt, Karl Michael; Hill, Matthew; Myers, Amanda J; Shoai, Maryam; de Rojas, Itziar; Tesi, Niccoló; Holstege, Henne; van der Flier, Wiesje M; Pijnenburg, Yolande A L; Ruiz, Agustin; Hardy, John; van der Lee, Sven; Escott-Price, Valentina; Borna, Sahar; Gomez-Cabello, Cesar A; Ali Haider, Syed; Genovese, Ariana; Prabha, Srinivasagam; Trabilsy, Maissa; Haider, Clifton R; Felton, Christopher L; Carter, Rickey E; McLeod, Christopher J; Bruce, Charles J; Jorge Forte, Antonio; WANG, NA; Doss, Sydney V; Chang, Yuzhou; Tauer, William; Ren, Yingxue; Qi, Fangfang; Bu, Guojun; Liu, Chia‐Chen; Wu, Long‐Jun; Santos, Victor B; Abdullah, Mohammad; Ellison, Justice; Ruan, Zhi; Ikezu, Tsuneya; Ikezu, Seiko

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease

血浆生物标志物和遗传学在阿尔茨海默病诊断和预测中的应用

Stevenson-Hoare, Joshua; Heslegrave, Amanda; Leonenko, Ganna; Fathalla, Dina; Bellou, Eftychia; Luckcuck, Lauren; Marshall, Rachel; Sims, Rebecca; Morgan, Bryan Paul; Hardy, John; de Strooper, Bart; Williams, Julie; Zetterberg, Henrik; Escott-Price, Valentina

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing

通过多基因风险和RNA测序发现,高尔基体、内质网和线粒体功能与阿尔茨海默病有关。

Crawford, Karen; Leonenko, Ganna; Baker, Emily; Grozeva, Detelina; Lan-Leung, Benoit; Holmans, Peter; Williams, Julie; O'Donovan, Michael C; Escott-Price, Valentina; Ivanov, Dobril K

Comparison of long-term effects of metformin on longevity between people with type 2 diabetes and matched non-diabetic controls

比较二甲双胍对2型糖尿病患者和匹配的非糖尿病对照组寿命的长期影响

Stevenson-Hoare, Joshua; Leonenko, Ganna; Escott-Price, Valentina

What does heritability of Alzheimer's disease represent?

阿尔茨海默病的遗传性代表着什么?

Baker, Emily; Leonenko, Ganna; Schmidt, Karl Michael; Hill, Matthew; Myers, Amanda J; Shoai, Maryam; de Rojas, Itziar; Tesi, Niccoló; Holstege, Henne; van der Flier, Wiesje M; Pijnenburg, Yolande A L; Ruiz, Agustin; Hardy, John; van der Lee, Sven; Escott-Price, Valentina