日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus.

开发和实施基于液相色谱-质谱联用技术的腺相关病毒多属性检测方法

Powers Thomas W, Mariani Shawn, Narepekha Halyna, Ryan Daniel, Sankar Savita, Lerch Thomas F

Enabling icIEF Peak Identification of AAV Capsid Proteins by Fractionation on MauriceFlex and Subsequent Analysis by LC-MS.

利用 MauriceFlex 进行分级分离,实现 AAV 衣壳蛋白的 icIEF 峰识别,并随后通过 LC-MS 进行分析

McElroy Will, Huang Sisi, He Xiaoping, Zhou Cheng, Heger Christopher D, Powers Thomas W, Anderson Melissa M, Sloan Courtney, Lerch Thomas F

Implementing a robust platform analytical procedure for measuring adeno-associated virus vector genome titer

实施一种稳健的平台分析程序,用于测量腺相关病毒载体基因组滴度

Powers, Thomas W; Sloan, Courtney D K; Stano, Don; Evans, Brad; Liu, Kang; Mariani, Shawn; Campbell, Jessica A; Lerch, Thomas F; Mo, Jim J

Development of an icIEF assay for monitoring AAV capsid proteins and application to gene therapy products

开发用于监测AAV衣壳蛋白的icIEF检测方法及其在基因治疗产品中的应用

He, Xiaoping Z; Powers, Thomas W; Huang, Sisi; Liu, Zhenjiu; Shi, Heliang; Orlet, John D; Mo, Jim J; Srinivasan, Saipraveen; Jacobs, Steven; Zhang, Kun; Runnels, Herbert A; Anderson, Melissa M; Lerch, Thomas F

Structure of AAV-DJ, a retargeted gene therapy vector: cryo-electron microscopy at 4.5 Å resolution

AAV-DJ(一种重定向基因治疗载体)的结构:4.5 Å分辨率的冷冻电镜成像

Lerch, Thomas F; O'Donnell, Jason K; Meyer, Nancy L; Xie, Qing; Taylor, Kenneth A; Stagg, Scott M; Chapman, Michael S

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse

美国夸特马皮肤弹性蛋白增生症的野生型和突变型环孢亲和素B的晶体结构

Boudko, Sergei P; Ishikawa, Yoshihiro; Lerch, Thomas F; Nix, Jay; Chapman, Michael S; Bächinger, Hans Peter

Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens

人胶原蛋白XV三聚化结构域的晶体结构:一种多聚蛋白胶原蛋白共有的强效三聚化单元

Wirz, Jacqueline A; Boudko, Sergei P; Lerch, Thomas F; Chapman, Michael S; Bächinger, Hans Peter

A pseudo-plaque method for infectious particle assay and clonal isolation of adeno-associated virus

一种用于腺相关病毒感染性颗粒检测和克隆分离的假噬斑法

Mitchell, Daniel A J; Lerch, Thomas F; Hare, Joan T; Chapman, Michael S

The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion

腺相关病毒3B型(AAV-3B)的结构:对受体结合和免疫逃逸的深入了解

Lerch, Thomas F; Xie, Qing; Chapman, Michael S

Twinned crystals of adeno-associated virus serotype 3b prove suitable for structural studies

腺相关病毒3b型血清型的孪晶适用于结构研究

Lerch, Thomas F; Xie, Qing; Ongley, Heather M; Hare, Joan; Chapman, Michael S