日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs.

用于体外发现和体内测试恶性疟原虫疟疾传播阻断药物的一体化流程

Brancucci Nicolas M B, Gumpp Christin, van Gemert Geert-Jan, Yu Xiao, Passecker Armin, Nardella Flore, Thommen Basil T, Chambon Marc, Turcatti Gerardo, Halby Ludovic, Blasco Benjamin, Duffey Maëlle, Arimondo Paola B, Bousema Teun, Scherf Artur, Leroy Didier, Kooij Taco W A, Rottmann Matthias, Voss Till S

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

消除疟疾传播需要通过脂质体吸收抗疟药物来靶向未成熟和成熟的配子体。

Naude, Mariska; van Heerden, Ashleigh; Reader, Janette; van der Watt, Mariëtte; Niemand, Jandeli; Joubert, Dorè; Siciliano, Giulia; Alano, Pietro; Njoroge, Mathew; Chibale, Kelly; Herreros, Esperanza; Leroy, Didier; Birkholtz, Lyn-Marié

Addressing the Intracellular Vestibule of the Plasmodial Lactate Transporter PfFNT by p-Substituted Inhibitors Amplifies In Vitro Activity

通过对质粒乳酸转运蛋白 PfFNT 的细胞内前庭进行 p-取代抑制剂处理,可增强其体外活性。

Nerlich, Cornelius; Tiedjens, Finn; Hertel, Robin; Henke, Björn; Häuer, Susan; Panitzsch, Lea S; Hansen, Kerrin; Franck, Ole; Mete, Antonio; Leroy, Didier; Schade, Dennis; Peifer, Christian; Hannus, Stefan; Becker, Frank; Wittlin, Sergio; Spielmann, Tobias; Beitz, Eric

Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates

遗传复杂性会改变恶性疟原虫无性繁殖期和配子体期对抗疟药物的敏感性

Greyling, Nicola; van der Watt, Mariëtte; Gwarinda, Hazel; van Heerden, Ashleigh; Greenhouse, Bryan; Leroy, Didier; Niemand, Jandeli; Birkholtz, Lyn-Marié

Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin

药物诱导的应激反应可导致恶性疟原虫环状体生长停滞,并降低体外寄生虫对青蒿素的敏感性。

Platon, Lucien; Leroy, Didier; Fidock, David A; Ménard, Didier

Defining the next generation of severe malaria treatment: a target product profile

定义下一代重症疟疾治疗方案:目标产品概况

Achan, Jane; Barry, Aïssata; Leroy, Didier; Kamara, George; Duparc, Stephan; Kaszubska, Wiweka; Gandhi, Preetam; Buffet, Bénédicte; Tshilab, Patrick; Ogutu, Bernhards; Taylor, Terrie; Krishna, Sanjeev; Richardson, Naomi; Ramachandruni, Hanu; Rietveld, Hans

Combating antimicrobial resistance in malaria, HIV and tuberculosis

对抗疟疾、艾滋病和结核病中的抗菌素耐药性

Duffey, Maëlle; Shafer, Robert W; Timm, Juliano; Burrows, Jeremy N; Fotouhi, Nader; Cockett, Mark; Leroy, Didier

Specific Proteomic Identification of Collagen-Binding Proteins in Escherichia coli O157:H7: Characterisation of OmpA as a Potent Vaccine Antigen

大肠杆菌 O157:H7 中胶原结合蛋白的特异性蛋白质组学鉴定:OmpA 作为强效疫苗抗原的表征

Ricardo Monteiro, Ingrid Chafsey, Nelly Caccia, Valentin Ageorges, Sabine Leroy, Didier Viala, Michel Hébraud, Valérie Livrelli, Mariagrazia Pizza, Alfredo Pezzicoli, Mickaël Desvaux

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro

寄生虫减少率(PRR)检测方法第二版:体外抗疟治疗后恶性疟原虫存活率的标准化评估

Walz, Annabelle; Duffey, Maëlle; Aljayyoussi, Ghaith; Sax, Sibylle; Leroy, Didier; Besson, Dominique; Burrows, Jeremy N; Cherkaoui-Rbati, Mohammed H; Gobeau, Nathalie; Westwood, Marie-Anne; Siethoff, Christoph; Gamo, Francisco-Javier; Mäser, Pascal; Wittlin, Sergio