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Chatelain, Frank C; de Oliveira, Barbara Ribeiro; Grataloup, Guillaume; Robert, Noé; Alameh, Malak; Thollet, Aurélie; Montnach, Jérôme; Feliciangeli, Sylvain; Rio, Aline; Bibault, Floriane; Bichet, Delphine; Bignucolo, Olivier; Extramiana, Fabrice; Majumder, Rupamanjari; Schott, Jean-Jacques; Probst, Vincent; Denjoy, Isabelle; Lesage, Florian; Loussouarn, Gildas; De Waard, Michel

ERG

ARC

发表日期：2026

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Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

TWIK1离子选择性对pH动态响应的机制基础

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-48067-w

Chatelain, Franck C; Gilbert, Nicolas; Bichet, Delphine; Jauch, Annaïse; Feliciangeli, Sylvain; Lesage, Florian; Bignucolo, Olivier

发表日期：2024

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Predicting hERG repolarization power at 37°C from recordings at room temperature

根据室温下的记录预测 37°C 下的 hERG 复极化能力

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.1266

Oliveira-Mendes, Barbara B R; Alameh, Malak; Montnach, Jérôme; Ollivier, Béatrice; Gibaud, Solène; Feliciangeli, Sylvain; Lesage, Florian; Charpentier, Flavien; Loussouarn, Gildas; De Waard, Michel; Baró, Isabelle

ERG

发表日期：2023

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A need for exhaustive and standardized characterization of ion channels activity. The case of K(V)11.1

需要对离子通道活性进行全面且标准化的表征。以K(V)11.1为例

期刊:Frontiers in Physiology

影响因子:3.4

doi:10.3389/fphys.2023.1132533

Alameh, Malak; Oliveira-Mendes, Barbara Ribeiro; Kyndt, Florence; Rivron, Jordan; Denjoy, Isabelle; Lesage, Florian; Schott, Jean-Jacques; De Waard, Michel; Loussouarn, Gildas

发表日期：2023

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A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity

用于评估 KCNH2 基因变异致病性的标准化 hERG 表型分析流程

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.609

Oliveira-Mendes, Barbara; Feliciangeli, Sylvain; Ménard, Mélissa; Chatelain, Frank; Alameh, Malak; Montnach, Jérôme; Nicolas, Sébastien; Ollivier, Béatrice; Barc, Julien; Baró, Isabelle; Schott, Jean-Jacques; Probst, Vincent; Kyndt, Florence; Denjoy, Isabelle; Lesage, Florian; Loussouarn, Gildas; De Waard, Michel

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

TREK1和TRAAK钾通道中多种刺激汇聚于单个门控

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2021.755826

Choveau, Frank S; Ben Soussia, Ismail; Bichet, Delphine; Franck, Chatelain C; Feliciangeli, Sylvain; Lesage, Florian

发表日期：2021

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TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects

TREK1通道激活作为一种新的镇痛策略，避免了阿片类药物的不良反应。

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.15243

Busserolles, Jérôme; Ben Soussia, Ismail; Pouchol, Laetitia; Marie, Nicolas; Meleine, Mathieu; Devilliers, Maïly; Judon, Céline; Schopp, Julien; Clémenceau, Loïc; Poupon, Laura; Chapuy, Eric; Richard, Serge; Noble, Florence; Lesage, Florian; Ducki, Sylvie; Eschalier, Alain; Lolignier, Stéphane

发表日期：2020

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Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

单个残基的突变促进脊椎动物和无脊椎动物双孔域钾通道的门控。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-019-08710-3

Ben Soussia, Ismail; El Mouridi, Sonia; Kang, Dawon; Leclercq-Blondel, Alice; Khoubza, Lamyaa; Tardy, Philippe; Zariohi, Nora; Gendrel, Marie; Lesage, Florian; Kim, Eun-Jin; Bichet, Delphine; Andrini, Olga; Boulin, Thomas

发表日期：2019

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Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.

对 TREK-1/TREK-2/TRAAK 缺陷小鼠进行高氧治疗与表面活性蛋白的减少有关

期刊:American Journal of Physiology-Lung Cellular and Molecular Physiology

影响因子:3.5

doi:10.1152/ajplung.00121.2017

Schwingshackl Andreas, Lopez Benjamin, Teng Bin, Luellen Charlean, Lesage Florian, Belperio John, Olcese Riccardo, Waters Christopher M

免疫/内分泌

发表日期：2017

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The family of K2P channels: salient structural and functional properties

K2P通道家族：显著的结构和功能特性

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/jphysiol.2014.287268

Feliciangeli, Sylvain; Chatelain, Frank C; Bichet, Delphine; Lesage, Florian

发表日期：2015

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SPARC: a structural pathogenicity algorithm for risk classification of hERG variants

SPARC：一种用于hERG变异风险分类的结构致病性算法

Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH

TWIK1离子选择性对pH动态响应的机制基础

Predicting hERG repolarization power at 37°C from recordings at room temperature

根据室温下的记录预测 37°C 下的 hERG 复极化能力

A need for exhaustive and standardized characterization of ion channels activity. The case of K(V)11.1

需要对离子通道活性进行全面且标准化的表征。以K(V)11.1为例

A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity

用于评估 KCNH2 基因变异致病性的标准化 hERG 表型分析流程

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

TREK1和TRAAK钾通道中多种刺激汇聚于单个门控

TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects

TREK1通道激活作为一种新的镇痛策略，避免了阿片类药物的不良反应。

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

单个残基的突变促进脊椎动物和无脊椎动物双孔域钾通道的门控。

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.

对 TREK-1/TREK-2/TRAAK 缺陷小鼠进行高氧治疗与表面活性蛋白的减少有关

The family of K2P channels: salient structural and functional properties

K2P通道家族：显著的结构和功能特性