日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes.

基于深度学习的从头发现和设计能够逆转疾病相关转录表型的治疗方法。

Xing Jing, Tan Mingdian, Leshchiner Dmitry, Sun Mengying, Abdelgied Mohamed, Huang Li, Paithankar Shreya, Uhl Katie, Shankar Rama, Lisabeth Erika, Aleiwi Bilal, Jager Tara, Lawson Cameron, Chen Ruoqiao, Giletto Matthew, Girgis Reda, Neubig Richard R, So Samuel, Ellsworth Edmund, Li Xiaopeng, Chua Mei-Sze, Zhou Jiayu, Chen Bin

A common network of residue-residue contacts underlies interactions between peptides and HLA class II complex

肽与HLA II类复合物之间的相互作用基于共同的残基-残基接触网络。

Kister, Alexander E; Leshchiner, Dmitry R; Kister, Ilya

A neoantigen vaccine generates antitumour immunity in renal cell carcinoma

新抗原疫苗可在肾细胞癌中产生抗肿瘤免疫力

Braun, David A; Moranzoni, Giorgia; Chea, Vipheaviny; McGregor, Bradley A; Blass, Eryn; Tu, Chloe R; Vanasse, Allison P; Forman, Cleo; Forman, Juliet; Afeyan, Alexander B; Schindler, Nicholas R; Liu, Yiwen; Li, Shuqiang; Southard, Jackson; Chang, Steven L; Hirsch, Michelle S; LeBoeuf, Nicole R; Olive, Oriol; Mehndiratta, Ambica; Greenslade, Haley; Shetty, Keerthi; Klaeger, Susan; Sarkizova, Siranush; Pedersen, Christina B; Mossanen, Matthew; Carulli, Isabel; Tarren, Anna; Duke-Cohan, Joseph; Howard, Alexis A; Iorgulescu, J Bryan; Shim, Bohoon; Simon, Jeremy M; Signoretti, Sabina; Aster, Jon C; Elagina, Liudmila; Carr, Steven A; Leshchiner, Ignaty; Getz, Gad; Gabriel, Stacey; Hacohen, Nir; Olsen, Lars R; Oliveira, Giacomo; Neuberg, Donna S; Livak, Kenneth J; Shukla, Sachet A; Fritsch, Edward F; Wu, Catherine J; Keskin, Derin B; Ott, Patrick A; Choueiri, Toni K

Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction

基于众包的单样本肿瘤亚克隆重建基准测试

Salcedo, Adriana; Tarabichi, Maxime; Buchanan, Alex; Espiritu, Shadrielle M G; Zhang, Hongjiu; Zhu, Kaiyi; Ou Yang, Tai-Hsien; Leshchiner, Ignaty; Anastassiou, Dimitris; Guan, Yuanfang; Jang, Gun Ho; Mootor, Mohammed F E; Haase, Kerstin; Deshwar, Amit G; Zou, William; Umar, Imaad; Dentro, Stefan; Wintersinger, Jeff A; Chiotti, Kami; Demeulemeester, Jonas; Jolly, Clemency; Sycza, Lesia; Ko, Minjeong; Wedge, David C; Morris, Quaid D; Ellrott, Kyle; Van Loo, Peter; Boutros, Paul C

Tamoxifen induces PI3K activation in uterine cancer.

他莫昔芬可诱导子宫癌细胞中PI3K活化。

Kübler Kirsten, Nardone Agostina, Anand Shankara, Gurevich Daniel, Gao Jianjiong, Droog Marjolein, Hermida-Prado Francisco, Akhshi Tara, Feiglin Ariel, Feit Avery S, Cohen Feit Gabriella, Dackus Gwen, Pun Matthew, Kuang Yanan, Cha Justin, Miller Mendy, Gregoricchio Sebastian, Lanfermeijer Mirthe, Cornelissen Sten, Gibson William J, Paweletz Cloud P, Van Allen Eliezer M, van Leeuwen Flora E, Nederlof Petra M, Nguyen Quang-Dé, Mourits Marian J E, Radovich Milan, Leshchiner Ignaty, Stewart Chip, Matulonis Ursula A, Zwart Wilbert, Maruvka Yosef E, Getz Gad, Jeselsohn Rinath

Majusculamide-o, a simplified marine natural product analog, exhibits potent and specific cancer cell cytotoxicity

Majusculamide-o 是一种简化的海洋天然产物类似物,具有强效且特异性的癌细胞毒性。

Niklas Alexander Wahl ,Naiara Lebrón-Acosta # ,Michelle Pérez-Cuevas # ,Angel Hernandez-Mejias ,Dmitry Leshchiner ,Frederick A Valeriote ,Eduardo J E Caro-Diaz ,Sachi Horibata

Liver Metastasis Risk and Timing in Pancreatic Cancer Patients Using Electronic Health Records

利用电子健康记录评估胰腺癌患者肝转移的风险和发生时间

Talukdar, Nabasmita; Yu, Zeshui; Zeng, Zheng; Zhang, Xiaodan; Lu, Ying; Joseph, Dimitri F; Leshchiner, Dmitry; Wang, Hui; Chen, Bin

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构 PI3Kα 抑制剂可克服由继发性 PIK3CA 突变介导的对正构抑制剂的靶向耐药性

Andreas Varkaris #, Ferran Fece de la Cruz #, Elizabeth E Martin #, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi

High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection

高通量适应性实验揭示了人类适应性沙门氏菌在压力和感染期间的特定脆弱性

Wang, Benjamin X; Leshchiner, Dmitry; Luo, Lijuan; Tuncel, Miles; Hokamp, Karsten; Hinton, Jay C D; Monack, Denise M

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.

EGFR突变型肺癌的发生机制是发育嵌合现象,表现为多原发肿瘤

Burr Risa, Leshchiner Ignaty, Costantino Christina L, Blohmer Martin, Sundaresan Tilak, Cha Justin, Seeger Karsen, Guay Sara, Danysh Brian P, Gore Ira, Jacobs Raquel A, Slowik Kara, Utro Filippo, Rhrissorrakrai Kahn, Levovitz Chaya, Barth Jaimie L, Dubash Taronish, Chirn Brian, Parida Laxmi, Sequist Lecia V, Lennerz Jochen K, Mino-Kenudson Mari, Maheswaran Shyamala, Naxerova Kamila, Getz Gad, Haber Daniel A