Lesley Probert相关文献与解析，生知库 | 链接生命科学的每一步

Vasileios Gouzouasis ，Ioannis Sarrigeorgiou ，Margaritis Tsifintaris ，Nikos Markoglou ，Urania Georgopoulou ，Peggy Lymberi ，Maria Anagnostouli ，Lesley Probert ，Antonis Giannakakis

多发性硬化症

发表日期：2025

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PBMC-Humanized Mouse Model for Multiple Sclerosis: Studying Immune Changes and CNS Involvement

利用外周血单核细胞构建人源化小鼠模型研究多发性硬化症：免疫变化和中枢神经系统受累情况

期刊:Bio-protocol

影响因子:1

doi:10.21769/BioProtoc.5312

Anastasia Dagkonaki ，Irini Papazian ，Vasileios Gouzouasis ，Ariadni Karles ，Maria Kourouvani ，Theodore Tselios ，Eirini Fragkiadaki ，Lesley Probert

IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

中枢神经系统巨噬细胞中 IKKβ 的缺失会增加神经元兴奋性并加速 EAE 的发病，而外周巨噬细胞中的 IKKβ 缺失则会降低疾病严重程度

期刊:Journal of Neuroinflammation

影响因子:9.3

doi:10.1186/s12974-024-03023-9

Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M Delgado-García, Lesley Probert #, Vasiliki Kyrargyri #

Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

自发性人类 CD8 T 细胞和自身免疫性脑脊髓炎诱发的 HLA-DRB1*15 阳性多发性硬化症人源化免疫系统小鼠脑和脊髓中的 CD4/CD8 T 细胞病变

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.88826

Irini Papazian, Maria Kourouvani, Anastasia Dagkonaki, Vasileios Gouzouasis, Lila Dimitrakopoulou, Nikolaos Markoglou, Fotis Badounas, Theodore Tselios, Maria Anagnostouli, Lesley Probert

Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis

甘露聚糖-MOG诱导循环Ly6ChiCCR2+单核细胞成熟，进而诱导抗原特异性耐受并逆转自身免疫性脑脊髓炎。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2022.972003

Anastasia Dagkonaki ，Athina Papalambrou ，Maria Avloniti ，Areti Gkika ，Maria Evangelidou ，Maria-Eleni Androutsou ，Theodore Tselios ，Lesley Probert

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

神经元 TNF 受体在中枢神经系统病理学中发挥着根本不同的作用：TNFR1 和 IKKβ 促进脱髓鞘中的小胶质细胞反应和组织损伤，而 TNFR2 可防止小鼠的兴奋性毒性

期刊:Journal of Neuroinflammation

影响因子:9.3

doi:10.1186/s12974-021-02200-4

Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, Konstantinos Kambas, Lida Iliopoulou, Roman Fischer, Roland E Kontermann, Maria C Denis, George Kollias, Hans Lassmann, Lesley Probert

Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology

探讨缺氧诱导因子 1 和假性缺氧在骨髓增生异常综合征病理生理中的作用

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms22084099

Ioanna E Stergiou, Konstantinos Kambas, Aikaterini Poulaki, Stavroula Giannouli, Theodora Katsila, Aglaia Dimitrakopoulou, Veroniki Vidali, Vasileios Mouchtouris, Ismini Kloukina, Evangelia Xingi, Stamatis N Pagakis, Lesley Probert, George P Patrinos, Konstantinos Ritis, Athanasios G Tzioufas, Micha

信号转导

发表日期：2021

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Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

Mannan-MOG35-55 可逆转实验性自身免疫性脑脊髓炎，诱导外周 2 型髓系反应，减少中枢神经系统炎症，并保护脊髓病变中的轴突

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2020.575451

Anastasia Dagkonaki, Maria Avloniti, Maria Evangelidou, Irini Papazian, Ioannis Kanistras, Vivian Tseveleki, Fotis Lampros, Theodore Tselios, Lise Torp Jensen, Wiebke Möbius, Torben Ruhwedel, Maria-Eleni Androutsou, John Matsoukas, Maria Anagnostouli, Hans Lassmann, Lesley Probert

免疫

神经

Immunology/Inflammation

发表日期：2020

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Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF

间充质干细胞保护神经元免受谷氨酸兴奋性毒性，包括减少 NMDA 触发的钙反应和表面 GluR1，部分由 TNF 介导

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms19030651

Irini Papazian, Vasiliki Kyrargyri, Maria Evangelidou, Anda Voulgari-Kokota, Lesley Probert

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

可溶性脑肿瘤坏死因子的治疗性抑制可通过增加小胶质细胞的髓鞘吞噬作用来促进髓鞘再生

期刊:JCI Insight

影响因子:6.3

doi:10.1172/jci.insight.87455

Maria Karamita, Christopher Barnum, Wiebke Möbius, Malú G Tansey, David E Szymkowski, Hans Lassmann, Lesley Probert

Double-stranded RNA antiviral signature in early multiple sclerosis

早期多发性硬化症中的双链RNA抗病毒特征

PBMC-Humanized Mouse Model for Multiple Sclerosis: Studying Immune Changes and CNS Involvement

利用外周血单核细胞构建人源化小鼠模型研究多发性硬化症：免疫变化和中枢神经系统受累情况

IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

中枢神经系统巨噬细胞中 IKKβ 的缺失会增加神经元兴奋性并加速 EAE 的发病，而外周巨噬细胞中的 IKKβ 缺失则会降低疾病严重程度

Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

自发性人类 CD8 T 细胞和自身免疫性脑脊髓炎诱发的 HLA-DRB1*15 阳性多发性硬化症人源化免疫系统小鼠脑和脊髓中的 CD4/CD8 T 细胞病变

Maturation of circulating Ly6ChiCCR2+ monocytes by mannan-MOG induces antigen-specific tolerance and reverses autoimmune encephalomyelitis

甘露聚糖-MOG诱导循环Ly6ChiCCR2+单核细胞成熟，进而诱导抗原特异性耐受并逆转自身免疫性脑脊髓炎。

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

神经元 TNF 受体在中枢神经系统病理学中发挥着根本不同的作用：TNFR1 和 IKKβ 促进脱髓鞘中的小胶质细胞反应和组织损伤，而 TNFR2 可防止小鼠的兴奋性毒性

Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology

探讨缺氧诱导因子 1 和假性缺氧在骨髓增生异常综合征病理生理中的作用

Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

Mannan-MOG35-55 可逆转实验性自身免疫性脑脊髓炎，诱导外周 2 型髓系反应，减少中枢神经系统炎症，并保护脊髓病变中的轴突

Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF

间充质干细胞保护神经元免受谷氨酸兴奋性毒性，包括减少 NMDA 触发的钙反应和表面 GluR1，部分由 TNF 介导

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

可溶性脑肿瘤坏死因子的治疗性抑制可通过增加小胶质细胞的髓鞘吞噬作用来促进髓鞘再生