日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

一种新型PLpro抑制剂改善了新冠肺炎长期症状的临床前模型的结果

M Bader Stefanie, Calleja Dale J, Devine Shane M, Kuchel Nathan W, Lu Bernadine G C, Wu Xinyu, Birkinshaw Richard W, Bhandari Reet, Loi Katie, Volpe Rohan, Khakham Yelena, Au Amanda E, Blackmore Timothy R, Mackiewicz Liana, Dayton Merle, Schaefer Jan, Scherer Lena, Stock Angus T, Cooney James P, Schoffer Kael, Maluenda Ana, Kleeman Elizabeth A, Davidson Kathryn C, Allison Cody C, Ebert Gregor, Chen Gong, Katneni Kasiram, Klemm Theresa A, Nachbur Ueli, Georgy Smitha Rose, Czabotar Peter E, Hannan Anthony J, Putoczki Tracy L, Tanzer Maria, Pellegrini Marc, Lechtenberg Bernhard C, Charman Susan A, Call Melissa J, Mitchell Jeffrey P, Lowes Kym N, Lessene Guillaume, Doerflinger Marcel, Komander David

Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins.

重新评估在透化血癌细胞上测试维奈托克或其他 BH3 模拟剂的试验,这些药物选择性地靶向促生存 BCL2 蛋白

Gong Jia-Nan, Djajawi Tirta M, Moujalled Donia M, Pomilio Giovanna, Khong Tiffany, Zhang Li-Ping, Fedele Pasquale L, Low Michael S, Anderson Mary Ann, Riffkin Christopher D, White Christine A, Lan Ping, Lessene Guillaume, Herold Marco J, Strasser Andreas, Spencer Andrew, Grigoriadis George, Wei Andrew H, van Delft Mark F, Roberts Andrew W, Huang David C S

Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape

SARS-CoV-2 木瓜蛋白酶样蛋白酶的突变分析揭示了其功能、结构和药物逃逸的要求

Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kathleen Zeglinski, Kym N Lowes, Dale J Calleja, Jeffrey P Mitchell, Guillaume Lessene, David Komander, Matthew E Call, Melissa J Call

Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis

VDAC2-BAK 复合物中的关键残基可以作为调节细胞凋亡的靶点

Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewson

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

BAX 基因的获得性突变可使急性髓系白血病对 BH3 模拟疗法产生耐药性

Moujalled Donia M, Brown Fiona C, Chua Chong Chyn, Dengler Michael A, Pomilio Giovanna, Anstee Natasha S, Litalien Veronique, Thompson Ella, Morley Thomas, MacRaild Sarah, Tiong Ing S, Morris Rhiannon, Dun Karen, Zordan Adrian, Shah Jaynish, Banquet Sebastien, Halilovic Ensar, Morris Erick, Herold Marco J, Lessene Guillaume, Adams Jerry M, Huang David C S, Roberts Andrew W, Blombery Piers, Wei Andrew H

Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

更正:抗癌药物APR-246可激活多种程序性细胞死亡过程以杀死恶性细胞。

Wang, Zilu; Hu, Huimin; Heitink, Luuk; Rogers, Kelly; You, Yue; Tan, Tao; Suen, Connie Li Wai; Garnham, Alex; Chen, Hao; Lieschke, Elizabeth; Diepstraten, Sarah T; Chang, Catherine; Chen, Tianwei; Moujalled, Diane; Sutherland, Kate; Lessene, Guillaume; Sieber, Oliver M; Visvader, Jane; Kelly, Gemma L; Strasser, Andreas

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

抗癌药物APR-246可以激活多种程序性细胞死亡过程来杀死恶性细胞

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells

BH3 模拟药物与替莫唑胺、JQ1 和铁死亡诱导剂协同杀死多形性胶质母细胞瘤细胞

Diane Moujalled, Adam G Southon #, Eiman Saleh #, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S Cross, Misty R Jenkins, Duong Nhu, Zilu Wang, Melissa X Shi, Ruth M Kluck, Guillaume Lessene, Stephanie Grabow, Ashley I Bush, Andreas Strasser

Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs

去除BFL-1可使某些黑色素瘤细胞对BH3模拟药物的杀伤作用更加敏感。

Gangoda, Lahiru; Schenk, Robyn L; Tai, Lin; Szeto, Pacman; Cheung, Jen G; Strasser, Andreas; Lessene, Guillaume; Shackleton, Mark; Herold, Marco J

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Lck 抑制剂 AMG-47a 可阻断坏死性凋亡,并提示 RIPK1 参与了 MLKL 下游的信号传导

Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J A Kersten, André L Samson, Mark F van Delft, David C S Huang, Hélène Jousset Sabroux, Guillaume Lessene, John Silke, James M Murphy