日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

What does BCL-2 do? From new molecular insights to the clinical implications

BCL-2 有什么作用?从新的分子机制到临床意义

Croce, Carlo M; Tait, Stephen W G; Garcia-Sáez, Ana J; Villunger, Andreas; Letai, Anthony; Walter, Harriet S; Dyer, Martin J S; Green, Douglas R; Shi, Yufang; Melino, Gerry

Venetoclax/FluBu2 RIC transplant followed by all-oral venetoclax/decitabine maintenance for poor-risk MDS/AML

对于预后不良的MDS/AML患者,先进行Venetoclax/FluBu2 RIC移植,随后进行全口服Venetoclax/地西他滨维持治疗。

Garcia, Jacqueline S; Kim, Haesook T; Murdock, H Moses; Bosch-Vilaseca, Anna; Panaro, Kevin M; Lim, Felicia; Fiorilla, Jade; Auriemma, Elise; Brock, Jennifer; Gooptu, Mahasweta; Ho, Vincent T; Cutler, Corey S; Shapiro, Roman; Kelkar, Amar H; Abel, Gregory A; DeAngelo, Daniel J; Stone, Richard M; Bat-Erdene, Denbaa; Ryan, Jeremy; Fell, Geoffrey; Letai, Anthony; Ritz, Jerome; Lindsley, R Coleman; Antin, Joseph H; Soiffer, Robert J

Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies.

通过对线粒体依赖性的定量分析,可以预测衰老过程中的细胞凋亡启动,进而预测特定的衰老细胞清除

MacDonald Julie A, Bradshaw Gary A, Jochems Fleur, Bernards René, Letai Anthony

Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma

将MCL-1抑制剂与CD37靶向嵌合抗原受体T细胞相结合,是治疗T细胞淋巴瘤的有效策略。

Heavican-Foral, Tayla B; Korell, Felix; Scarfò, Irene; Wiggers, Caroline R M; B, Allen Thayakumar; Eisenbies, Zachary; Powers, Foster; Hegel, Justin; Liu, Jianlin; Kulp, Steffen; Silva, Harrison; Wu, Gongwei; Letai, Anthony; Stegmaier, Kimberly; Lohr, Jens G; Weinstock, David M; Maus, Marcela V; Knoechel, Birgit

Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia

维奈托克联合低强度化疗治疗成人急性淋巴细胞白血病

Luskin, Marlise R; Shimony, Shai; Keating, Julia; Winer, Eric S; Garcia, Jacqueline S; Stone, Richard M; Jabbour, Elias; Flamand, Yael; Stevenson, Kristen; Ryan, Jeremy; Zeng, Zhihong; Letai, Anthony; Konopleva, Marina; Jain, Nitin; DeAngelo, Daniel J

Dynamic BH3 profiling predicts clinical outcomes in acute myeloid leukemia

动态 BH3 谱分析可预测急性髓系白血病的临床结果

Minihane, Emma-Jayne; Krotee, Leah; Wu, Jason; Thornton, Lindsey; Fell, Geoffrey; Herter, Sonja; Ryan, Jeremy; Jakkani, Amulya; Marinchev, Kate; Lane, Andrew A; Luskin, Marlise R; Winer, Eric S; Chen, Evan C; Shimony, Shai; Wadleigh, Martha; Vedula, Rahul; Volpe, Virginia O; Reilly, Christopher; Galinsky, Ilene; DeAngelo, Daniel J; Stone, Richard M; Neuberg, Donna S; Letai, Anthony; Garcia, Jacqueline S

Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia

治疗耐药性TP53突变急性髓系白血病中可靶向的BIRC5依赖性

Mamdouh, Ahmed M; Lim, Fang Qi; Mi, Yang; Olesinski, Elyse A; Chan, Cheryl Gek Teng; Jasdanwala, Shaista; Lin, Xiao Xian; Wang, Yichen; Tan, Jordan Yong Ming; Bhatia, Karanpreet Singh; Sapozhnikova, Valeriia; Wang, Chuqi; Mahesh, Aarthi Nivasini; Liang, Daniel Tan En; Chitkara, Nishtha; Mertins, Philipp; Hogdal, Leah; Brown, Brandon D; Haferlach, Torsten; Lobry, Camille; Lindsley, Coleman; Puissant, Alexandre; Ho, Han Kiat; Das, Sanjukta; Letai, Anthony; Kornblau, Steven M; Krönke, Jan; Ayoub, Edward; Itahana, Koji; Andreeff, Michael; Bhatt, Shruti

TP53 mutations drive therapy resistance via post-mitochondrial caspase blockade.

TP53 突变通过阻断线粒体后 caspase 导致治疗耐药性

Mamdouh Ahmed M, Olesinski Elyse A, Lim Fang Qi, Jasdanwala Shaista, Mi Yang, Lin Nicole Si En, Liang Daniel Tan En, Chitkara Nishtha, Hogdal Leah, Lindsley R Coleman, Letai Anthony, Itahana Koji, Bhatt Shruti

The Siren Song of Synergy

协同作用的诱惑之歌

Bhola, Patrick D; Letai, Anthony

Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts.

AML获得性多药耐药是由复发性髓母细胞凋亡启动不足引起的

Olesinski Elyse A, Bhatia Karanpreet Singh, Wang Chuqi, Pioso Marissa S, Lin Xiao Xian, Mamdouh Ahmed M, Ng Shu Xuan, Sandhu Vedant, Jasdanwala Shaista Shabbir, Yilma Binyam, Bohl Stephan, Ryan Jeremy A, Malani Disha, Luskin Marlise R, Kallioniemi Olli, Porkka Kimmo, Adamia Sophia, Chng Wee Joo, Osato Motomi, Weinstock David M, Garcia Jacqueline S, Letai Anthony, Bhatt Shruti