日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular determinants of ASIC1 modulation by divalent cations

二价阳离子调控ASIC1的分子决定因素

Liu, Yi; Ma, Jichun; DesJarlais, Renee L; Hagan, Rebecca; Rech, Jason; Liu, Changlu; Miller, Robyn; Schoellerman, Jeffrey; Luo, Jinquan; Letavic, Michael; Grasberger, Bruce; Maher, Michael P

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1

小分子调控酸敏感离子通道门控的分子机制和结构基础 1

Liu, Yi; Ma, Jichun; DesJarlais, Renee L; Hagan, Rebecca; Rech, Jason; Lin, David; Liu, Changlu; Miller, Robyn; Schoellerman, Jeffrey; Luo, Jinquan; Letavic, Michael; Grasberger, Bruce; Maher, Michael

1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators

1H-吡咯并[3,2-b]吡啶 GluN2B 选择性负变构调节剂

Chrovian, Christa C; Soyode-Johnson, Akinola; Wall, Jessica L; Rech, Jason C; Schoellerman, Jeff; Lord, Brian; Coe, Kevin J; Carruthers, Nicholas I; Nguyen, Leslie; Jiang, Xiaohui; Koudriakova, Tatiana; Balana, Bartosz; Letavic, Michael A

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

JNJ-55308942 的神经精神药理学研究:在神经炎症和快感缺失动物模型中评估靶向 P2X7 离子通道的临床候选药物

Anindya Bhattacharya ,Brian Lord ,Jan-Sebastian Grigoleit ,Yingbo He ,Ian Fraser ,Shannon N Campbell ,Natalie Taylor ,Leah Aluisio ,Jason C O'Connor ,Mariusz Papp ,Christa Chrovian ,Nicholas Carruthers ,Timothy W Lovenberg ,Michael A Letavic

Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

选择性抑制食欲素-2受体可阻止小鼠应激诱导的ACTH释放

Yun, Sujin; Wennerholm, Michelle; Shelton, Jonathan E; Bonaventure, Pascal; Letavic, Michael A; Shireman, Brock T; Lovenberg, Timothy W; Dugovic, Christine

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

短暂的 P2X7 受体拮抗作用可持久减少实验性颞叶癫痫的自发性癫痫发作和神经胶质增生

Alba Jimenez-Pacheco, Miguel Diaz-Hernandez, Marina Arribas-Blázquez, Amaya Sanz-Rodriguez, Luis A Olivos-Oré, Antonio R Artalejo, Mariana Alves, Michael Letavic, M Teresa Miras-Portugal, Ronan M Conroy, Norman Delanty, Michael A Farrell, Donncha F O'Brien, Anindya Bhattacharya, Tobias Engel, David

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

对特定癫痫模型中 P2X7 受体拮抗剂的严格评估

Wolfgang Fischer, Heike Franke, Ute Krügel, Heiko Müller, Klaus Dinkel, Brian Lord, Michael A Letavic, David C Henshall, Tobias Engel

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists

脑穿透性P2X7受体拮抗剂的合成、构效关系及药理学表征

Savall, Brad M; Wu, Duncan; De Angelis, Meri; Carruthers, Nicholas I; Ao, Hong; Wang, Qi; Lord, Brian; Bhattacharya, Anindya; Letavic, Michael A

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

新型中枢通透性 P2X7 受体拮抗剂 JNJ-47965567 的药理学表征

Anindya Bhattacharya, Qi Wang, Hong Ao, James R Shoblock, Brian Lord, Leah Aluisio, Ian Fraser, Diane Nepomuceno, Robert A Neff, Natalie Welty, Timothy W Lovenberg, Pascal Bonaventure, Alan D Wickenden, Michael A Letavic

Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon

JNJ-39220675阻断脑组胺H3受体:在麻醉狒狒中使用[¹¹C]GSK189254进行的临床前PET研究

Logan, Jean; Carruthers, Nicholas I; Letavic, Michael A; Sands, Steven; Jiang, Xiaohui; Shea, Colleen; Muench, Lisa; Xu, Youwen; Carter, Pauline; King, Payton; Fowler, Joanna S