日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

MCM10, a novel YAP1/TEAD4 target, drives gastric cancer progression by bridging DNA replication to stemness acquisition

MCM10 是一种新型的 YAP1/TEAD4 靶点，它通过连接 DNA 复制和干细胞特性获得来驱动胃癌的进展。

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-026-02623-8
Xie, Fuda; Leung, Hoi Wing; Lyu, Yang; Yu, Peiyao; Feng, Tiejun; Chen, Bonan; Wu, Jialin; Tham, Jenson; Fang, Canbin; Cheung, Alvin H K; Chow, Chit; Jiang, Jianhui; Hu, Jintao; Zhang, Fengbin; Zhu, Chaowei; Zhong, Keli; Sun, Meiheng; Zhang, Ge; Yu, Sifan; Xu, Dazhi; Wang, Shouyu; Huang, Bing; Zhuang, Kangmin; Luo, Xiaobei; Li, Aimin; Guo, Qing; Gao, Chanchan; Zhang, Bin; Ma, Yuan; Wu, William Kk; An, Liwei; Wong, Chi Chun; Yu, Jun; To, Ka Fai; Kang, Wei
胃癌
肿瘤
YAP1
MCM10
肿瘤免疫
细胞生物学
YAP
干细胞
发育与干细胞
发表日期：2026
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STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

STK3是YAP1的转录靶点，也是胃癌发生过程中Hippo和Wnt信号通路相互作用的关键组分。

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02391-x
Xie, Fuda; Lyu, Yang; Chen, Bonan; Leung, Hoi Wing; Yu, Peiyao; Feng, Tiejun; Fang, Canbin; Cheung, Alvin H K; Zhou, Bin; Jiang, Jianhui; Zhang, Ge; Xu, Dazhi; Li, Liang; Jiang, Chen; Chen, Jianwu; Zhou, Zhaocai; An, Liwei; Huang, Bing; Zhuang, Kangmin; Luo, Xiaobei; Leung, Kam Tong; To, Ching Hei; Ma, Brigette By; Wong, Chi Chun; Wu, William Kk; Yu, Jun; To, Ka Fai; Kang, Wei
胃癌
肿瘤
YAP1
STK3
肿瘤免疫
信号转导
Wnt/β-Catenin
YAP
Hippo
发表日期：2025
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Update in the treatment of cirrhotic patients with portal vein thrombosis

肝硬化合并门静脉血栓患者治疗进展

期刊:Clinical and Molecular Hepatology
影响因子:16.9
doi:10.3350/cmh.2025.0411
Wu, Jialin; Deng, Xinyi; Luo, Junyang; Jiang, Zaibo; Xie, Fuda; Chen, Bonan; Leung, Hoi Wing; Zhang, Ge; To, Ka Fai; Kang, Wei
心血管
肝硬化
发表日期：2025
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POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer.

POSTN 仅在癌症相关成纤维细胞中激活，导致胃癌患者预后不良

期刊:Molecular and Clinical Oncology
影响因子:1.4
doi:10.3892/mco.2025.2877
To Ching Hei, Xie Fuda, Yu Peiyao, Wu Jialin, Lyu Yang, Chen Bonan, Feng Tiejun, Leung Hoi Wing, Kang Wei
细胞生物学
胃癌
发表日期：2025
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A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging

利用人工智能对大规模组学数据集进行全面分析，揭示了可用于治疗癌症和衰老的新型双重靶点。

期刊:Aging Cell
影响因子:7.1
doi:10.1111/acel.14017
Pun, Frank W; Leung, Geoffrey Ho Duen; Leung, Hoi Wing; Rice, Jared; Schmauck-Medina, Tomas; Lautrup, Sofie; Long, Xi; Liu, Bonnie Hei Man; Wong, Chun Wai; Ozerov, Ivan V; Aliper, Alex; Ren, Feng; Rosenberg, Ari J; Agrawal, Nishant; Izumchenko, Evgeny; Fang, Evandro F; Zhavoronkov, Alex
肿瘤
衰老
肿瘤免疫
发表日期：2023
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Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform

利用 PandaOmics（一种人工智能驱动的生物靶点发现平台）识别与衰老和多形性胶质母细胞瘤相关的双重用途治疗靶点

期刊:Aging-Us
影响因子:3.9
doi:10.18632/aging.204678
Olsen, Andrea; Harpaz, Zachary; Ren, Christopher; Shneyderman, Anastasia; Veviorskiy, Alexander; Dralkina, Maria; Konnov, Simon; Shcheglova, Olga; Pun, Frank W; Leung, Geoffrey Ho Duen; Leung, Hoi Wing; Ozerov, Ivan V; Aliper, Alex; Korzinkin, Mikhail; Zhavoronkov, Alex
细胞生物学
衰老
发表日期：2023
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Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

利用 PandaOmics（一种人工智能驱动的生物靶点发现平台）识别肌萎缩侧索硬化症的治疗靶点

期刊:Frontiers in Aging Neuroscience
影响因子:4.5
doi:10.3389/fnagi.2022.914017
Pun, Frank W; Liu, Bonnie Hei Man; Long, Xi; Leung, Hoi Wing; Leung, Geoffrey Ho Duen; Mewborne, Quinlan T; Gao, Junli; Shneyderman, Anastasia; Ozerov, Ivan V; Wang, Ju; Ren, Feng; Aliper, Alexander; Bischof, Evelyne; Izumchenko, Evgeny; Guan, Xiaoming; Zhang, Ke; Lu, Bai; Rothstein, Jeffrey D; Cudkowicz, Merit E; Zhavoronkov, Alex
发表日期：2022
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Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

利用 PandaOmics AI 驱动的发现引擎预测基于衰老的双重用途疾病和年龄相关靶点的特征

期刊:Aging-Us
影响因子:3.9
doi:10.18632/aging.203960
Pun, Frank W; Leung, Geoffrey Ho Duen; Leung, Hoi Wing; Liu, Bonnie Hei Man; Long, Xi; Ozerov, Ivan V; Wang, Ju; Ren, Feng; Aliper, Alexander; Izumchenko, Evgeny; Moskalev, Alexey; de Magalhães, João Pedro; Zhavoronkov, Alex
衰老
发表日期：2022
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RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.

RA-XII 通过减少细胞粘附和侵袭以及促进基质降解来抑制乳腺肿瘤小鼠的肿瘤生长和转移

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/srep16985
Leung Hoi-Wing, Zhao Si-Meng, Yue Grace Gar-Lee, Lee Julia Kin-Ming, Fung Kwok-Pui, Leung Ping-Chung, Tan Ning-Hua, Lau Clara Bik-San
肿瘤
发表日期：2015
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