日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation.

用于扩展细胞外靶向蛋白降解的细胞因子受体靶向嵌合体工具箱。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2524129123
Kumru Kaan, Yao Zi, Holmes Brandon B, Zhao Fangzhu, Zhang Yun, Ferrara Emilio, Peters-Clarke Trenton M, Leung Kevin K, Wells James A
蛋白降解
信号转导
细胞生物学
免疫/内分泌
发表日期：2026
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Targeted shedding of extracellular membrane proteins by induced protease recruitment

通过诱导蛋白酶募集靶向脱落细胞外膜蛋白

期刊:
影响因子:
doi:10.64898/2026.02.17.706468
Yao, Zi; Zhao, Fangzhu; Miao, Kun; Peters-Clarke, Trenton M; Zhang, Yun; Ganjave, Snehal D; Vázquez-Maldonado, Angel L; Wu, Yan; Kumru, Kaan; Jumaa, Hammam; Leung, Kevin K; Wells, James A
细胞生物学
发表日期：2026
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Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome

利用工程化蛋白质和化学工具探测细胞表面蛋白质组

期刊:Chemical Reviews
影响因子:55.8
doi:10.1021/acs.chemrev.4c00554
Leung, Kevin K; Schaefer, Kaitlin; Lin, Zhi; Yao, Zi; Wells, James A
细胞生物学
发表日期：2025
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β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE，导致神经元tau蛋白病理和毒性增加

期刊:Molecular Neurodegeneration
影响因子:17.5
doi:10.1186/s13024-025-00883-4
Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Miller Bruce L, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A
神经科学
细胞生物学
发表日期：2025
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Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines

缺氧诱导胰腺腺癌（PDAC）细胞系细胞表面广泛的蛋白质和蛋白水解重塑

期刊:Journal of Proteome Research
影响因子:3.6
doi:10.1021/acs.jproteome.4c01037
Lui, Irene; Schaefer, Kaitlin; Kirkemo, Lisa L; Zhou, Jie; Perera, Rushika M; Leung, Kevin K; Wells, James A
细胞生物学
肿瘤
肿瘤免疫
发表日期：2025
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A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.

用于扩展细胞外靶向蛋白降解的细胞因子受体靶向嵌合体（kineTAC）工具箱

期刊:
影响因子:
doi:10.1101/2025.09.02.673832
Kumru Kaan, Yao Zi, Holmes Brandon B, Zhao Fangzhu, Zhang Yun, Ferrara Emilio, Peters-Clarke Trenton M, Leung Kevin K, Wells James A
细胞生物学
发表日期：2025
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Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery.

低密度脂蛋白受体靶向嵌合体用于膜蛋白降解和增强药物递送

期刊:
影响因子:
doi:10.1101/2025.06.06.658366
Zhao Fangzhu, Wu Yan, Schaefer Kaitlin, Zhang Yun, Miao Kun, Yao Zi, Ganjave Snehal D, Kumru Kaan, Peters-Clarke Trenton M, Inague Alex, Olzmann James A, Leung Kevin K, Wells James A
其它
药物研究
发表日期：2025
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β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.

β-淀粉样蛋白诱导小胶质细胞表达GPC4和APOE，导致神经元Tau病理和毒性增加

期刊:
影响因子:
doi:10.1101/2025.02.20.637701
Holmes Brandon B, Weigel Thaddeus K, Chung Jesseca M, Kaufman Sarah K, Apresa Brandon I, Byrnes James R, Kumru Kaan S, Vaquer-Alicea Jaime, Gupta Ankit, Rose Indigo V L, Zhang Yun, Nana Alissa L, Alter Dina, Grinberg Lea T, Spina Salvatore, Leung Kevin K, Condello Carlo, Kampmann Martin, Seeley William W, Coutinho-Budd Jaeda C, Wells James A
神经科学
细胞生物学
发表日期：2025
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Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells

从单个催化位点进行光邻近标记，可以实现体外和细胞内蛋白质伴侣的卡宾标记的校准和分辨率提高。

期刊:ACS Central Science
影响因子:10.4
doi:10.1021/acscentsci.3c01473
Bartholow, Thomas G; Burroughs, Paul W W; Elledge, Susanna K; Byrnes, James R; Kirkemo, Lisa L; Garda, Virginia; Leung, Kevin K; Wells, James A
细胞生物学
发表日期：2024
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Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy

B细胞和前列腺细胞中Myc诱导的细胞表面蛋白质组的大规模重塑为免疫治疗创造了新的机遇。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2018861118
Chen, Wentao; Mou, Kurt Yun; Solomon, Paige; Aggarwal, Rahul; Leung, Kevin K; Wells, James A
B细胞
细胞生物学
免疫/内分泌
发表日期：2021
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