日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H(1) receptor

利用基于片段的药物发现方法将3D支架转化为高效配体:以组胺H(1)受体为例

Dekker, Tom; van Linden, Oscar P J; Lim, Herman D; Dekker, Mabel E; Vischer, Henry F; Leurs, Rob; van der Meer, Tiffany; Buzink, Maurice C M L; Hamilton, David J; Zarzycka, Barbara; Janssen, Elwin; Wijtmans, Maikel; de Esch, Iwan J P

Automated navigation of condensate phase behavior with active machine learning

利用主动机器学习实现冷凝相行为的自动导航

Leurs, Yannick H A; van den Hout, Willem; Gardin, Andrea; van Dongen, Joost L J; Rodriguez-Abetxuko, Andoni; Erkamp, Nadia A; van Hest, Jan C M; Grisoni, Francesca; Brunsveld, Luc

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.

CXCR3 对小分子识别的结构可视化揭示了 CXCR3-CXCR7 系统中的双重激动作用

Saha Shirsha, Sano Fumiya K, Sharma Saloni, Ganguly Manisankar, Dalal Annu, Mishra Sudha, Tiwari Divyanshu, Akasaka Hiroaki, Kobayashi Takaaki A, Roy Nabarun, Zaidi Nashrah, Itoh Yuzuru, Leurs Rob, Banerjee Ramanuj, Shihoya Wataru, Nureki Osamu, Shukla Arun K

Stabilization of Condensate Interfaces Using Dynamic Protein Insertion

利用动态蛋白质插入稳定凝聚界面

Leurs, Yannick H A; Giezen, Sanne N; Li, Yudong; van den Hout, Willem; Beeren, Jay; van den Aker, Linn J M; Voets, Ilja K; van Hest, Jan C M; Brunsveld, Luc

Recent Developments in the Optical Control of Adrenergic Signaling

肾上腺素能信号光学控制的最新进展

Shi, Shuang; Cao, Yangzhi; Wijtmans, Maikel; Vischer, Henry F; Leurs, Rob

Photo-clenbuterol: Optical Control of β(2)-Adrenergic Receptor Signaling by Photoswitchable Ligand Efficacy.

光克仑特罗:通过光开关配体效力对β(2)-肾上腺素能受体信号传导进行光学控制

Cao Yangzhi, Shi Shuang, Does Simone A H, Buzink Christian M L, Gao Meichun, de Esch Iwan J P, Vischer Henry F, Wijtmans Maikel, Leurs Rob

Reconstructing historical catch trends of threatened sharks and rays based on fisher ecological knowledge

基于渔民的生态知识,重建受威胁鲨鱼和鳐鱼的历史捕捞趋势。

Leurs, Guido; Jabado, Rima W; Camará, Assana; Dos Santos, Lilísio; Nonque, Diosnes Manuel; Zuidewind, Thije J; Barry, Iça; Campredon, Pierre; Blaschke, Benja; de Boer, Karin; Hijner, Nadia; Olff, Han; Pontes, Samuel Ledo; Regalla, Aissa; Walsh, Matthew Bjerregaard; Govers, Laura L

Prevalence, characteristics, and outcomes of patients with low baseline C-reactive protein in giant cell arteritis

巨细胞动脉炎患者基线C反应蛋白水平低的患病率、特征和预后

Pichon, Samuel; Koether, Vincent; Leurs, Amélie; Chepy, Aurelien; Gachet, Benoît; Sobanski, Vincent; Launay, David; Lambert, Marc; Hachulla, Eric

Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3

首个非典型趋化因子受体3的光开关小分子激动剂的设计、合成和药理学表征

Bérenger, Sophie; Adamska, Justyna M; Deflorian, Francesca; de Graaf, Chris; Palmer, Christie B; Szpakowska, Martyna; Chevigné, Andy; de Esch, Iwan J P; Zarzycka, Barbara; Vischer, Henry F; Wijtmans, Maikel; Leurs, Rob

Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment.

用于开发半衰期延长的酰化肽基 CGRP 受体拮抗剂以治疗偏头痛的管线

Kristensen Jens Bjelke, Elster Lisbeth, Lundh Morten, Ballarín-González Borja, Alexopoulou Flora, Kræmer Martin, Jensen Ditte Marie, Leurs Ulrike, Nielsen Jens Christian, Hansen Henrik H, Haanes Kristian A, Degn Matilda