日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed.

NLPD-PKA 是一种神经退行性疾病,其中 PRKAR1B L50R 变体表达,该疾病会影响受其影响的个体的蛋白激酶 A 的变构调节。

Benjamin-Zukerman Tal, Pane Valeria, Safadi-Safa Rania, Solomon Meir, Lev-Ram Varda, Aboraya Mohammad, Dakwar Anwar, Bertinetti Daniela, Hoy Andrew, Mol Merel O, van Swieten John, Maillard Rodrigo, Herberg Friedrich W, Ilouz Ronit

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice

热量限制可增加胰岛素敏感性,促进小鼠β细胞稳态和寿命

Cristiane Dos Santos #, Amanda Cambraia #, Shristi Shrestha, Melanie Cutler, Matthew Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Danielle Dean, Jean Philippe Cartailler, Patrick E MacDonald, Martin Hetzer, Mark Ellisman, Rafael Arrojo E Dri

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species

PRKAR1B基因的突变驱动着跨物种的神经退行性疾病的病理机制。

Benjamin-Zukerman, Tal; Shimon, Gilat; Gaine, Marie E; Dakwar, Anwar; Peled, Netta; Aboraya, Mohammad; Masri-Ismail, Ashar; Safadi-Safa, Rania; Solomon, Meir; Lev-Ram, Varda; Rissman, Robert A; Mayrhofer, Johanna E; Raffeiner, Andrea; Mol, Merel O; Argue, Benney M R; McCool, Shaylah; Doan, Binh; van Swieten, John; Stefan, Eduard; Abel, Ted; Ilouz, Ronit

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

神经元周围网络能稳定突触回路的印迹吗?

Varda Lev-Ram, Sakina Palida Lemieux, Thomas J Deerinck, Eric A Bushong, Alex J Perez, Denise R Pritchard, Brandon H Toyama, Sung Kyu R Park, Daniel B McClatchy, Jeffrey N Savas, Michael Whitney, Stephen R Adams, Mark H Ellisman, John Yates 3rd, Roger Y Tsien

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo

通过在体外和体内对HAPLN1进行基因编码标记,可以对神经元周围网状结构和神经元细胞外基质进行成像。

Lemieux, Sakina P; Lev-Ram, Varda; Tsien, Roger Y; Ellisman, Mark H

Age Mosaicism across Multiple Scales in Adult Tissues.

成人组织中多尺度年龄镶嵌现象

Arrojo E Drigo Rafael, Lev-Ram Varda, Tyagi Swati, Ramachandra Ranjan, Deerinck Thomas, Bushong Eric, Phan Sebastien, Orphan Victoria, Lechene Claude, Ellisman Mark H, Hetzer Martin W

Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells

长寿命蛋白质的可视化揭示了有丝分裂后细胞核内的年龄镶嵌现象

Brandon H Toyama, Rafael Arrojo E Drigo, Varda Lev-Ram, Ranjan Ramachandra, Thomas J Deerinck, Claude Lechene, Mark H Ellisman, Martin W Hetzer

Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy.

利用光镜和电镜的基因标记揭示了多个脑区黑视素-视网膜神经节细胞的突触特化

Kim Keun-Young, Rios Luis C, Le Hiep, Perez Alex J, Phan Sébastien, Bushong Eric A, Deerinck Thomas J, Liu Yu Hsin, Ellisman Maya A, Lev-Ram Varda, Ju Suyeon, Panda Sneha A, Yoon Sanghee, Hirayama Masatoshi, Mure Ludovic S, Hatori Megumi, Ellisman Mark H, Panda Satchidananda

Split-miniSOG for Spatially Detecting Intracellular Protein-Protein Interactions by Correlated Light and Electron Microscopy

Split-miniSOG 用于通过关联光和电子显微镜在空间上检测细胞内蛋白质 - 蛋白质相互作用

Daniela Boassa, Sakina P Lemieux, Varda Lev-Ram, Junru Hu, Qing Xiong, Sebastien Phan, Mason Mackey, Ranjan Ramachandra, Ryan Emily Peace, Stephen R Adams, Mark H Ellisman, John T Ngo

Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

通过小鼠脑马赛克成像鉴定蛋白激酶 A 异构体特异性亚细胞定位和功能

Ronit Ilouz, Varda Lev-Ram, Eric A Bushong, Travis L Stiles, Dinorah Friedmann-Morvinski, Christopher Douglas, Jeffrey L Goldberg, Mark H Ellisman, Susan S Taylor