日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamic Supercoiling Sponsors Transcription Amplification by MYC

动态超螺旋通过 MYC 促进转录扩增

Jha, Rajiv Kumar; Kouzine, Fedor; Wang, Bo; Phelan, James D; Das, Subhendu K; Lewis, Brian A; Levens, David

The plusses and minuses of DNA torsion

DNA扭转的利弊

Henikoff, Steven; Levens, David L

A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc-haploinsufficiency in the absence of p53.

在缺乏 p53 的情况下,通过 Myc 单倍体不足的剂量补偿,揭示了内源性 Myc 的致瘤阈值。

Bao Xiaozhong, Abdullaev Zied, Das Subhendu K, Zgonc Valerie, Ylaya Kris, Pittaluga Stefania, Hewitt Stephen M, Sedivy John M, Pack Svetlana J, Mackem Susan, Levens David

Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome.

MYC拓扑体活性过高会引发急性DNA损伤、MYC降解,并被p53拓扑体取代

Das Subhendu K, Karmakar Sharmistha, Venkatachalapathy Harish, Jha Rajiv Kumar, Batchelor Eric, Levens David

MYC: a complex problem

MYC:一个复杂的问题

Das, Subhendu K; Lewis, Brian A; Levens, David

MYC function and regulation in physiological perspective

MYC 的功能和生理调控

Jha, Rajiv Kumar; Kouzine, Fedor; Levens, David

Non-equilibrium structural dynamics of supercoiled DNA plasmids exhibits asymmetrical relaxation.

超螺旋DNA质粒的非平衡结构动力学表现出不对称弛豫

Shaheen Cynthia, Hastie Cameron, Metera Kimberly, Scott Shane, Zhang Zhi, Chen Sitong, Gu Gracia, Weber Lisa, Munsky Brian, Kouzine Fedor, Levens David, Benham Craig, Leslie Sabrina

Mechanical determinants of chromatin topology and gene expression

染色质拓扑结构和基因表达的机械决定因素

Jha, Rajiv Kumar; Levens, David; Kouzine, Fedor

Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

攻克“不可成药”的MYCN致癌转录因子:克服以往障碍,影响儿童癌症治疗

Wolpaw, Adam J; Bayliss, Richard; Büchel, Gabriele; Dang, Chi V; Eilers, Martin; Gustafson, W Clay; Hansen, Gwenn H; Jura, Natalia; Knapp, Stefan; Lemmon, Mark A; Levens, David; Maris, John M; Marmorstein, Ronen; Metallo, Steven J; Park, Julie R; Penn, Linda Z; Rape, Michael; Roussel, Martine F; Shokat, Kevan M; Tansey, William P; Verba, Kliment A; Vos, Seychelle M; Weiss, William A; Wolf, Elmar; Mossé, Yaël P

Targeting CDK9 for the Treatment of Glioblastoma

靶向 CDK9 治疗胶质母细胞瘤

Ranjan, Alice; Pang, Ying; Butler, Madison; Merchant, Mythili; Kim, Olga; Yu, Guangyang; Su, Yu-Ting; Gilbert, Mark R; Levens, David; Wu, Jing