日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic disease

高致病性禽流感病毒H5N1 2.3.4.4b分支B3.13基因型对小鼠具有高度致病性,可迅速引起急性肺部和神经系统疾病。

Tipih, Thomas; Mariappan, Vignesh; Yinda, Kwe C; Meade-White, Kimberly; Lewis, Matthew; Okumura, Atsushi; McCarthy, Natalie; Altynova, Ekaterina; Leventhal, Shanna S; Bushmaker, Trenton; Clancy, Chad S; de Wit, Emmie; Munster, Vincent J; Feldmann, Heinz; Rosenke, Kyle

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice.

2.3.4.4b 分支(而非历史分支 1)HA 复制 RNA 疫苗可保护小鼠免受牛 H5N1 攻击

Hawman David W, Tipih Thomas, Hodge Eddie, Stone E Taylor, Warner Nikole, McCarthy Natalie, Granger Brian, Meade-White Kimberly, Leventhal Shanna, Hatzakis Kiara, Park Stephanie, Gaffney Karen, Rosenke Kyle, Erasmus Jesse H, Feldmann Heinz

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.

复制型RNA疫苗可保护食蟹猴免受克里米亚-刚果出血热的侵害

Hawman David W, Leventhal Shanna, Meade-White Kimberly, Graham William, Gaffney Karen, Khandhar Amit, Murray Justin, Prado-Smith Jessy, Shaia Carl, Saturday Greg, Buda Henry, Moise Lenny, Erasmus Jesse, Feldmann Heinz

Single dose VSV-based vaccine protects mice against lethal heterologous Crimean-Congo hemorrhagic fever virus challenge

单剂量VSV疫苗可保护小鼠免受致命性异源克里米亚-刚果出血热病毒攻击。

Tipih, Thomas; Leventhal, Shanna S; Meade-White, Kimberly; Lewis, Matthew; Bushmaker, Trenton; Shaia, Carl; Marzi, Andrea; Feldmann, Heinz; Hawman, David W

A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

一种复制型RNA疫苗在恒河猴克里米亚-刚果出血热模型中提供了保护作用。

Hawman, David W; Leventhal, Shanna S; Meade-White, Kimberly; Khandhar, Amit; Murray, Justin; Lovaglio, Jamie; Shaia, Carl; Saturday, Greg; Hinkley, Troy; Erasmus, Jesse; Feldmann, Heinz

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

加速DNA疫苗接种方案可在猕猴模型中提供针对克里米亚-刚果出血热病毒攻击的保护

Hawman, David W; Meade-White, Kimberly; Leventhal, Shanna; Appelberg, Sofia; Ahlén, Gustaf; Nikouyan, Negin; Clancy, Chad; Smith, Brian; Hanley, Patrick; Lovaglio, Jamie; Mirazimi, Ali; Sällberg, Matti; Feldmann, Heinz

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

即使中和抗体减弱,复制子RNA疫苗仍可在非人灵长类动物体内诱导针对SARS-CoV-2的持久保护性免疫。

O'Connor, Megan A; Hawman, David W; Meade-White, Kimberly; Leventhal, Shanna; Song, Wenjun; Randall, Samantha; Archer, Jacob; Lewis, Thomas B; Brown, Brieann; Fredericks, Megan N; Sprouse, Kaitlin R; Tunggal, Hillary C; Maughan, Mara; Iwayama, Naoto; Ahrens, Chul; Garrison, William; Wangari, Solomon; Guerriero, Kathryn A; Hanley, Patrick; Lovaglio, Jamie; Saturday, Greg; Veesler, David; Edlefsen, Paul T; Khandhar, Amit P; Feldmann, Heinz; Fuller, Deborah Heydenburg; Erasmus, Jesse H

An Intramuscular DNA Vaccine for SARS-CoV-2 Decreases Viral Lung Load but Not Lung Pathology in Syrian Hamsters.

针对 SARS-CoV-2 的肌肉注射 DNA 疫苗可降低叙利亚仓鼠肺部病毒载量,但不能改善肺部病理

Leventhal Shanna S, Clancy Chad, Erasmus Jesse, Feldmann Heinz, Hawman David W

Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models

羟氯喹预防和治疗在猕猴和仓鼠SARS-CoV-2疾病模型中无效。

Rosenke, Kyle; Jarvis, Michael A; Feldmann, Friederike; Schwarz, Benjamin; Okumura, Atsushi; Lovaglio, Jamie; Saturday, Greg; Hanley, Patrick W; Meade-White, Kimberly; Williamson, Brandi N; Hansen, Frederick; Perez-Perez, Lizette; Leventhal, Shanna; Tang-Huau, Tsing-Lee; Callison, Julie; Haddock, Elaine; Stromberg, Kaitlin A; Scott, Dana; Sewell, Graham; Bosio, Catharine M; Hawman, David; de Wit, Emmie; Feldmann, Heinz

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

单剂量复制型RNA疫苗可在非人灵长类动物体内诱导产生针对SARS-CoV-2的中和抗体

Erasmus, Jesse H; Khandhar, Amit P; Walls, Alexandra C; Hemann, Emily A; O'Connor, Megan A; Murapa, Patience; Archer, Jacob; Leventhal, Shanna; Fuller, Jim; Lewis, Thomas; Draves, Kevin E; Randall, Samantha; Guerriero, Kathryn A; Duthie, Malcolm S; Carter, Darrick; Reed, Steven G; Hawman, David W; Feldmann, Heinz; Gale, Michael; Veesler, David; Berglund, Peter; Fuller, Deborah Heydenburg