日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Thorough QT Study to Assess the Effects of Milvexian on Cardiac Repolarization in Healthy Participants

一项全面的QT间期研究旨在评估米尔维西安对健康受试者心脏复极化的影响

Zannikos, Peter; Park, JongHanne; Dari, Anna; Takhtoukh, Samiha; Levesque, Paul; Plotnikov, Alexei N; Mitra, Amitava; Ajavon-Hartmann, Antoinette; Merali, Samira; Perez Ruixo, Juan Jose; Goyal, Navin

Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes

舒张压降低可能预示着衰竭的人类心肌细胞具有更高的促心律失常倾向。

Zhou, Xin; Levesque, Paul; Chaudhary, Khuram; Davis, Myrtle; Rodriguez, Blanca

Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

是时候进行全面整合的非临床-临床风险评估,以简化QT间期延长责任认定流程了:制药行业的视角

Vargas, Hugo M; Rolf, Michael G; Wisialowski, Todd A; Achanzar, William; Bahinski, Anthony; Bass, Alan; Benson, Charles T; Chaudhary, Khuram W; Couvreur, Nicolas; Dota, Corina; Engwall, Michael J; Michael Foley, C; Gallacher, David; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Guth, Brian; Himmel, Herbert M; Hegele-Hartung, Christa; Ito, Maki; Jenkinson, Stephen; Chiba, Katsuyoshi; Lagrutta, Armando; Levesque, Paul; Martel, Eric; Okai, Yoshiko; Peri, Ravikumar; Pointon, Amy; Qu, Yusheng; Teisman, Ard; Traebert, Martin; Yoshinaga, Takashi; Gintant, Gary A; Leishman, Derek J; Valentin, Jean-Pierre

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P(1)) Modulators: Optimization of the PK, PD, and Safety Profiles

芳基醚衍生的鞘氨醇-1-磷酸受体(S1P(1))调节剂:药代动力学、药效学和安全性特征的优化

Xiao, Zili; Yang, Michael G; Dhar, T G Murali; Xiao, Hai-Yun; Gilmore, John L; Marcoux, David; McIntyre, Kim W; Taylor, Tracy L; Shi, Hong; Levesque, Paul C; Marino, Anthony M; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D; Sun, Huadong; Xie, Jenny H; Carter, Percy H; Dyckman, Alaric J

Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961]

对“评估 hERG 阻滞效力的系统策略及其在新的心脏安全范式中的意义”的更正[毒理学和应用药理学卷 394C (2020) 114961]

Ridder, Bradley J; Leishman, Derek J; Bridgland-Taylor, Matthew; Samieegohar, Mohammadreza; Han, Xiaomei; Wu, Wendy W; Randolph, Aaron; Tran, Phu; Sheng, Jiansong; Danker, Timm; Lindqvist, Anders; Konrad, Daniel; Hebeisen, Simon; Polonchuk, Liudmila; Gissinger, Evgenia; Renganathan, Muthukrishnan; Koci, Bryan; Wei, Haiyang; Fan, Jingsong; Levesque, Paul; Kwagh, Jae; Imredy, John; Zhai, Jin; Rogers, Marc; Humphries, Edward; Kirby, Robert; Stoelzle-Feix, Sonja; Brinkwirth, Nina; Rotordam, Maria Giustina; Becker, Nadine; Friis, Søren; Rapedius, Markus; Goetze, Tom A; Strassmaier, Tim; Okeyo, George; Kramer, James; Kuryshev, Yuri; Wu, Caiyun; Himmel, Herbert; Mirams, Gary R; Strauss, David G; Bardenet, Remi; Li, Zhihua

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

评估 hERG 阻滞效力的系统策略及其在新心脏安全范式中的意义

Ridder Bradley J, Leishman Derek J, Bridgland-Taylor Matthew, Samieegohar Mohammadreza, Han Xiaomei, Wu Wendy W, Randolph Aaron, Tran Phu, Sheng Jiansong, Danker Timm, Lindqvist Anders, Konrad Daniel, Hebeisen Simon, Polonchuk Liudmila, Gissinger Evgenia, Renganathan Muthukrishnan, Koci Bryan, Wei Haiyang, Fan Jingsong, Levesque Paul, Kwagh Jae, Imredy John, Zhai Jin, Rogers Marc, Humphries Edward, Kirby Robert, Stoelzle-Feix Sonja, Brinkwirth Nina, Rotordam Maria Giustina, Becker Nadine, Friis Søren, Rapedius Markus, Goetze Tom A, Strassmaier Tim, Okeyo George, Kramer James, Kuryshev Yuri, Wu Caiyun, Himmel Herbert, Mirams Gary R, Strauss David G, Bardenet Rémi, Li Zhihua

Identification of potent tricyclic prodrug S1P(1) receptor modulators

鉴定强效三环类前药S1P(1)受体调节剂

Marcoux, David; Xiao, Hai-Yun; Murali Dhar, T G; Xie, Jenny; Lehman-McKeeman, Lois D; Wu, Dauh-Rurng; Dabros, Marta; Yang, Xiaoxia; Taylor, Tracy L; Zhou, Xia D; Heimrich, Elizabeth M; Thomas, Rochelle; McIntyre, Kim W; Shi, Hong; Levesque, Paul C; Sun, Huadong; Yang, Zheng; Marino, Anthony M; Cornelius, Georgia; D'Arienzo, Celia J; Gupta, Anuradha; Pragalathan, Bala; Rampulla, Richard; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Salter-Cid, Luisa; Lombardo, Louis J; Carter, Percy H; Dyckman, Alaric J

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials

BMS-986104的鉴定和临床前药理学研究:一种在临床试验中应用的差异化S1P1受体调节剂

Dhar, T G Murali; Xiao, Hai-Yun; Xie, Jenny; Lehman-McKeeman, Lois D; Wu, Dauh-Rurng; Dabros, Marta; Yang, Xiaoxia; Taylor, Tracy L; Zhou, Xia D; Heimrich, Elizabeth M; Thomas, Rochelle; McIntyre, Kim W; Warrack, Bethanne; Shi, Hong; Levesque, Paul C; Zhu, Jia L; Hennan, James; Balimane, Praveen; Yang, Zheng; Marino, Anthony M; Cornelius, Georgia; D'Arienzo, Celia J; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Salter-Cid, Luisa; Barrish, Joel C; Carter, Percy H; Dyckman, Alaric J

Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor

发现 5-苯基-N-(吡啶-2-基甲基)-2-(嘧啶-5-基)喹唑啉-4-胺是一种强效的 I Kur 抑制剂

Finlay, Heather J; Johnson, James A; Lloyd, John L; Jiang, Ji; Neels, James; Gunaga, Prashantha; Banerjee, Abhisek; Dhondi, Naveen; Chimalakonda, Anjaneya; Mandlekar, Sandhya; Conder, Mary Lee; Sale, Harinath; Xing, Dezhi; Levesque, Paul; Wexler, Ruth R