日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overcoming functional and translational challenges of cellular immunotherapies for solid tumors

克服实体瘤细胞免疫疗法的功能和转化挑战

Chen, Yi-Ching; Chen, Kok-Siong; Levine, Bruce L; Shah, Khalid

Clinical trial results provide the rationale to protect dual HIV-specific T cells with a signaling-defective HIV fusion inhibitor.

临床试验结果为使用信号缺陷型 HIV 融合抑制剂保护双重 HIV 特异性 T 细胞提供了理论依据。

Tebas Pablo, Jadlowsky Julie K, Zhou Yuqi, Pampena M Betina, Leslie George J, Liu Nan, Srivatsa Sriram, Maldini Colby R, Wang Jingxin, Tsang Chungdhak Jaming, Mohamed Ola, Romano Josephine, Haggarty Beth, Plesa Gabriela, Gaymon Avery L, Brennan Andrea L, Veloso Elizabeth, Levine Bruce L, Putt Mary E, Kulikovskaya Irina, Gonzalez Vanessa, Fraietta Joseph A, Betts Michael R, Hoxie James A, Riley James L

Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations

构建具有突破当前限制的单载体逻辑门控CAR-T细胞,使其转基因大小达到预期水平

Rommel, Philipp C; Engel, Nils W; Malachowski, Julia K; Shukla, Divanshu; Hodson, Isabella R; Gonzales, Donna; van der Loo, Johannes C M; Young, Regina M; Riley, James L; Levine, Bruce L; June, Carl H

Unanswered questions following reports of secondary malignancies after CAR-T cell therapy

CAR-T细胞疗法后出现继发性恶性肿瘤的报道引发了一些未解之谜

Levine, Bruce L; Pasquini, Marcelo C; Connolly, John E; Porter, David L; Gustafson, Michael P; Boelens, Jaap J; Horwitz, Edwin M; Grupp, Stephan A; Maus, Marcela V; Locke, Frederick L; Ciceri, Fabio; Ruggeri, Annalisa; Snowden, John; Heslop, Helen E; Mackall, Crystal L; June, Carl H; Sureda, Anna M; Perales, Miguel-Angel

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

经 CCR5 编辑的 CD4+ T 细胞可增强 HIV 特异性免疫力,从而实现 HIV 病毒反弹后复制的控制。

Tebas, Pablo; Jadlowsky, Julie K; Shaw, Pamela A; Tian, Lifeng; Esparza, Erin; Brennan, Andrea L; Kim, Sukyung; Naing, Soe Yu; Richardson, Max W; Vogel, Ashley N; Maldini, Colby R; Kong, Hong; Liu, Xiaojun; Lacey, Simon F; Bauer, Anya M; Mampe, Felicity; Richman, Lee P; Lee, Gary; Ando, Dale; Levine, Bruce L; Porter, David L; Zhao, Yangbing; Siegel, Don L; Bar, Katharine J; June, Carl H; Riley, James L

Regulatory Considerations for Genome-Edited T-cell Therapies

基因编辑T细胞疗法的监管考量

Jadlowsky, Julie K; Chang, Ju-Fang; Spencer, David H; Warrington, John M; Levine, Bruce L; June, Carl H; Fraietta, Joseph A; Singh, Nathan

Paving the Road for Chimeric Antigen Receptor T Cells: American Society for Transplantation and Cellular Therapy 80/20 Task Force Consensus on Challenges and Solutions to Improving Efficiency of Clinical Center Certification and Maintenance of Operations for Commercially Approved Immune Effector Cell Therapies

为嵌合抗原受体T细胞铺平道路:美国移植和细胞治疗学会80/20工作组关于提高商业批准的免疫效应细胞疗法临床中心认证和运营维护效率的挑战和解决方案的共识

Nikiforow, Sarah; Frigault, Matthew J; Frey, Noelle V; Gardner, Rebecca A; Komanduri, Krishna V; Perales, Miguel-Angel; Kebriaei, Partow; Warkentin, Phyllis Irene; Pasquini, Marcelo; Aho, Joy Lynn; Levine, Bruce L; Heslop, Helen E; Hlucky, Tracey L; Habucky, Karen; Gharibo, Mecide; Jagasia, Madan; Locke, Frederick L

Anti-CD19 CAR T cells in combination with ibrutinib for the treatment of chronic lymphocytic leukemia

抗CD19 CAR T细胞联合伊布替尼治疗慢性淋巴细胞白血病

Gill, Saar; Vides, Vanessa; Frey, Noelle V; Hexner, Elizabeth O; Metzger, Susan; O'Brien, Megan; Hwang, Wei-Ting; Brogdon, Jennifer L; Davis, Megan M; Fraietta, Joseph A; Gaymon, Avery L; Gladney, Whitney L; Lacey, Simon F; Lamontagne, Anne; Mato, Anthony R; Maus, Marcela V; Melenhorst, J Joseph; Pequignot, Edward; Ruella, Marco; Shestov, Maksim; Byrd, John C; Schuster, Stephen J; Siegel, Donald L; Levine, Bruce L; June, Carl H; Porter, David L

Flexor Digitorum Longus Transfer for Posterior Tibial Tendon Dysfunction is the Standard of Care: Does the Evidence Support It?

屈趾长肌腱转移术治疗胫后肌腱功能障碍是标准治疗方法:证据支持吗?

Fesnak, Andrew D; Hanley, Patrick J; Levine, Bruce L; Goldberg, Terry E; Lee, Seonjoo; Devanand, Davangere; Schneider, Lon S S; Gravelin, Misty; Rigan, Laurie; Adamo, Joan E; Ellison, Sharon; Segear, Erika; Parrish, Amanda; Deeter, Christine; Hamill, Jennifer; Soliz, Erik; Idris, Ahamed; Mashour, George A; Weatherwax, Kevin J; Kasture, Sarang P; Mistry, Alpesh; Low, Samantha; Fisher, Andrew; Bond, Alistair P; Lambert, Laura-Ann; Jayatilaka, Lara; Philpott, Matthew; Fisher, Lauren; Mason, Lyndon W; Molloy, Andrew P; Dooley, Sean W; Evashwick-Rogler, Thomas; Murawski, Christopher D; Guyton, Gregory P; Smyth, Niall A

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia

在复发或难治性急性淋巴细胞白血病的儿童和青少年中,人源化 CD19 靶向嵌合抗原受体 (CAR) T 细胞治疗未接受过 CAR 治疗和接受过 CAR 治疗的儿童和青少年。

Myers, Regina M; Li, Yimei; Barz Leahy, Allison; Barrett, David M; Teachey, David T; Callahan, Colleen; Fasano, Christina C; Rheingold, Susan R; DiNofia, Amanda; Wray, Lisa; Aplenc, Richard; Baniewicz, Diane; Liu, Hongyan; Shaw, Pamela A; Pequignot, Edward; Getz, Kelly D; Brogdon, Jennifer L; Fesnak, Andrew D; Siegel, Donald L; Davis, Megan M; Bartoszek, Chelsie; Lacey, Simon F; Hexner, Elizabeth O; Chew, Anne; Wertheim, Gerald B; Levine, Bruce L; June, Carl H; Grupp, Stephan A; Maude, Shannon L