日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability

定向进化获得高效聚碳酸酯解聚酶及其优异的操作稳定性

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202525215
Jones, Henry A; Hutton, Amy E; Harris-Jukes, Dominic; Davidson, John; Johannissen, Linus O; Levy, Colin W; Shaver, Michael P; Green, Anthony P
发表日期：2026
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Efficient and selective energy transfer photoenzymes powered by visible light

高效且选择性的能量转移光酶，由可见光驱动

期刊:Nature Chemistry
影响因子:20.2
doi:10.1038/s41557-025-01820-0
Crawshaw, Rebecca; Smithson, Ross; Hofer, Johannes; Hardy, Florence J; Roberts, George W; Trimble, Jonathan S; Kohn, Anna R; Levy, Colin W; Drost, Deborah A; Merten, Christian; Heyes, Derren J; Obexer, Richard; Bach, Thorsten; Green, Anthony P
发表日期：2025
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Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors

利用简单的磷酸供体酶促合成关键的RNA治疗构建模块

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-67366-4
Meng, Qinglong; Benckendorff, Caecilie; Morrill, Charlotte; Zhuo, Ying; Egerström, Annette; Ní Cheallaigh, Aisling; Derrington, Sasha R; Obexer, Richard; Ortmayer, Mary; Levy, Colin W; Finnigan, James D; Charnock, Simon J; Turner, Nicholas J; Miller, Gavin J; Lovelock, Sarah L
发表日期：2025
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Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00478
Kavanagh Madeline E, McLean Kirsty J, Gilbert Sophie H, Amadi Cecilia N, Snee Matthew, Tunnicliffe Richard B, Arora Kriti, Boshoff Helena I M, Fanourakis Alexander, Rebollo-Lopez Maria Jose, Ortega Fatima, Levy Colin W, Munro Andrew W, Leys David, Abell Chris, Coyne Anthony G
代谢
肠道菌群
发表日期：2025
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Photocobilins integrate B(12) and bilin photochemistry for enzyme control

光胆素整合维生素B12和胆素的光化学反应，从而控制酶活性。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-024-46995-1
Zhang, Shaowei; Jeffreys, Laura N; Poddar, Harshwardhan; Yu, Yuqi; Liu, Chuanyang; Patel, Kaylee; Johannissen, Linus O; Zhu, Lingyun; Cliff, Matthew J; Yan, Cunyu; Schirò, Giorgio; Weik, Martin; Sakuma, Michiyo; Levy, Colin W; Leys, David; Heyes, Derren J; Scrutton, Nigel S
发表日期：2024
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Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

利用扩展遗传密码探测非血红素铁加氧酶中的铁氧基反应性

期刊:ACS Catalysis
影响因子:13.1
doi:10.1021/acscatal.4c02365
Hardy, Florence J; Quesne, Matthew G; Gérard, Emilie F; Zhao, Jingming; Ortmayer, Mary; Taylor, Christopher J; Ali, Hafiz S; Slater, Jeffrey W; Levy, Colin W; Heyes, Derren J; Bollinger, J Martin Jr; de Visser, Sam P; Green, Anthony P
发表日期：2024
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Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

期刊:
影响因子:
doi:10.1101/2024.10.28.620643
Kavanagh, Madeline E; McLean, Kirsty J; Gilbert, Sophie H; Amadi, Cecilia; Snee, Matthew; Tunnicliffe, Richard B; Arora, Kriti; Boshoff, Helena I; Fanourakis, Alexander; Rebello-Lopez, Maria Jose; Ortega-Muro, Fatima; Levy, Colin W; Munro, Andrew W; Leys, David; Abell, Chris; Coyne, Anthony G
代谢
发表日期：2024
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Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

基于结构的结核分枝杆菌CYP125和CYP142抑制剂的发现

期刊:Chemistry-A European Journal
影响因子:3.7
doi:10.1002/chem.202203868
Katariya, Mona M; Snee, Matthew; Tunnicliffe, Richard B; Kavanagh, Madeline E; Boshoff, Helena I M; Amadi, Cecilia N; Levy, Colin W; Munro, Andrew W; Abell, Chris; Leys, David; Coyne, Anthony G; McLean, Kirsty J
发表日期：2023
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How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity

10-表-古贝波尔合成酶如何避免过早反应淬灭，从而高纯度地形成三环产物

期刊:ACS Catalysis
影响因子:13.1
doi:10.1021/acscatal.2c03155
Whitehead, Joshua N; Leferink, Nicole G H; Komati Reddy, Gajendar; Levy, Colin W; Hay, Sam; Takano, Eriko; Scrutton, Nigel S
发表日期：2022
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Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

儿茶酚-O-甲基转移酶的赤道活性位点压缩和静电重组

期刊:ACS Catalysis
影响因子:13.1
doi:10.1021/acscatal.9b00174
Czarnota, Sylwia; Johannissen, Linus O; Baxter, Nicola J; Rummel, Felix; Wilson, Alex L; Cliff, Matthew J; Levy, Colin W; Scrutton, Nigel S; Waltho, Jonathan P; Hay, Sam
发表日期：2019
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