日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity

退伍军人的早发性痴呆:脑多发性病变和临床病理复杂性

Diego Iacono, Patricia Lee, Brian L Edlow, Nichelle Gray, Bruce Fischl, Kimbra Kenney, Henry L Lew, Scott Lozanoff, Peter Liacouras, John Lichtenberger, Kristen Dams-O'Connor, David Cifu, Sidney R Hinds, Daniel P Perl

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

NT5C2突变驱动复发性淋巴母细胞白血病硫嘌呤耐药的结构和机制

Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad; Carpenter, Zachary; Ambesi-Impiombato, Alberto; Sánchez-Martín, Marta; Kirschner-Schwabe, Renate; Lew, Scott; Seetharaman, Jayaraman; Tong, Liang; Ferrando, Adolfo A

Using a second-order differential model to fit data without baselines in protein isothermal chemical denaturation.

使用二阶微分模型拟合蛋白质等温化学变性中无基线的数据

Tang Chuanning, Lew Scott, He Dacheng

Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila

嗜肺军团菌胞质核苷酸酶 II 的变构调节和底物活化

Srinivasan, Bharath; Forouhar, Farhad; Shukla, Arpit; Sampangi, Chethana; Kulkarni, Sonia; Abashidze, Mariam; Seetharaman, Jayaraman; Lew, Scott; Mao, Lei; Acton, Thomas B; Xiao, Rong; Everett, John K; Montelione, Gaetano T; Tong, Liang; Balaram, Hemalatha

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations

丙二酰辅酶A脱羧酶的晶体结构揭示了其催化机制和致病突变。

Froese, D Sean; Forouhar, Farhad; Tran, Timothy H; Vollmar, Melanie; Kim, Yi Seul; Lew, Scott; Neely, Helen; Seetharaman, Jayaraman; Shen, Yang; Xiao, Rong; Acton, Thomas B; Everett, John K; Cannone, Giuseppe; Puranik, Sriharsha; Savitsky, Pavel; Krojer, Tobias; Pilka, Ewa S; Kiyani, Wasim; Lee, Wen Hwa; Marsden, Brian D; von Delft, Frank; Allerston, Charles K; Spagnolo, Laura; Gileadi, Opher; Montelione, Gaetano T; Oppermann, Udo; Yue, Wyatt W; Tong, Liang

A bidirectional system for the dynamic small molecule control of intracellular fusion proteins

一种用于动态小分子控制细胞内融合蛋白的双向系统

Neklesa, Taavi K; Noblin, Devin J; Kuzin, Alexander P; Lew, Scott; Seetharaman, Jayaraman; Acton, Thomas B; Kornhaber, Gregory J; Xiao, Rong; Montelione, Gaetano Thomas; Tong, Liang; Crews, Craig M

Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction

利用计算机设计具有Morita-Baylis-Hillman反应催化活性的烯酮结合蛋白

Bjelic, Sinisa; Nivón, Lucas G; Çelebi-Ölçüm, Nihan; Kiss, Gert; Rosewall, Carolyn F; Lovick, Helena M; Ingalls, Erica L; Gallaher, Jasmine Lynn; Seetharaman, Jayaraman; Lew, Scott; Montelione, Gaetano Thomas; Hunt, John Francis; Michael, Forrest Edwin; Houk, K N; Baker, David

Computational design of catalytic dyads and oxyanion holes for ester hydrolysis

酯水解催化二元体和氧阴离子空穴的计算设计

Richter, Florian; Blomberg, Rebecca; Khare, Sagar D; Kiss, Gert; Kuzin, Alexandre P; Smith, Adam J T; Gallaher, Jasmine; Pianowski, Zbigniew; Helgeson, Roger C; Grjasnow, Alexej; Xiao, Rong; Seetharaman, Jayaraman; Su, Min; Vorobiev, Sergey; Lew, Scott; Forouhar, Farhad; Kornhaber, Gregory J; Hunt, John F; Montelione, Gaetano T; Tong, Liang; Houk, K N; Hilvert, Donald; Baker, David

Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations

一种对脂质A生物合成至关重要的特化酰基载体蛋白的结构,该蛋白含有处于开放和封闭构象的极长链脂肪酸。

Ramelot, Theresa A; Rossi, Paolo; Forouhar, Farhad; Lee, Hsiau-Wei; Yang, Yunhuang; Ni, Shuisong; Unser, Sarah; Lew, Scott; Seetharaman, Jayaraman; Xiao, Rong; Acton, Thomas B; Everett, John K; Prestegard, James H; Hunt, John F; Montelione, Gaetano T; Kennedy, Michael A

Structures of domains I and IV from YbbR are representative of a widely distributed protein family

YbbR蛋白的结构域I和IV代表了一种广泛分布的蛋白质家族。

Barb, Adam W; Cort, John R; Seetharaman, Jayaraman; Lew, Scott; Lee, Hsiau-Wei; Acton, Thomas; Xiao, Rong; Kennedy, Michael A; Tong, Liang; Montelione, Gaetano T; Prestegard, James H