日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

作者更正:靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Khoury, Nathalie; Pizzo, Michelle E; Discenza, Claire B; Joy, David; Tatarakis, David; Todorov, Mihail Ivilinov; Negwer, Moritz; Ha, Connie; De Melo, Gabrielly L; Sarrafha, Lily; Simon, Matthew J; Chan, Darren; Chau, Roni; Chew, Kylie S; Chow, Johann; Clemens, Allisa; Robles-Colmenares, Yaneth; Dugas, Jason C; Duque, Joseph; Kaltenecker, Doris; Kane, Holly; Leung, Amy; Lozano, Edwin; Moshkforoush, Arash; Roche, Elysia; Sandmann, Thomas; Tong, Mabel; Xa, Kaitlin; Zhou, Yinhan; Lewcock, Joseph W; Ertürk, Ali; Thorne, Robert G; Calvert, Meredith E K; Yu Zuchero, Y Joy

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

早期干预抗Aβ免疫疗法可减轻小胶质细胞活化,而不会导致残余斑块处的细胞耗竭。

Lis de Weerd ,Selina Hummel ,Stephan A Müller ,Iñaki Paris ,Thomas Sandmann ,Marie Eichholtz ,Robin Gröger ,Amelie L Englert ,Stephan Wagner ,Connie Ha ,Sonnet S Davis ,Valerie Warkins ,Dan Xia ,Brigitte Nuscher ,Anna Berghofer ,Marvin Reich ,Astrid F Feiten ,Kai Schlepckow ,Michael Willem ,Stefan F Lichtenthaler ,Joseph W Lewcock ,Kathryn M Monroe ,Matthias Brendel ,Christian Haass

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome

LRRK2激酶活性调节溶酶体中与帕金森病相关的脂质

Michael T Maloney # ,Xiang Wang # ,Rajarshi Ghosh ,Shan V Andrews ,Romeo Maciuca ,Shababa T Masoud ,Maayan Agam ,Richard M Caprioli ,Giuseppe Astarita ,Vitaliy V Bondar ,John Chen ,Chi-Lu Chiu ,Sonnet S Davis ,Audrey Cheuk-Nga Ho ,Hoang N Nguyen ,Nicholas E Propson ,Michelle L Reyzer ,Oliver B Davis ,Matthew C Deen ,Sha Zhu ,Gilbert Di Paolo ,David J Vocadlo ,Anthony A Estrada ,Javier de Vicente ,Joseph W Lewcock ,Annie Arguello ,Jung H Suh ,Sarah Huntwork-Rodriguez ,Anastasia G Henry

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Nathalie Khoury,Michelle E Pizzo,Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha,Gabrielly L De Melo,Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow,Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker,Holly Kane,Amy Leung,Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

可溶性 VCAM-1 可作为药效学脑脊液标志物,用于监测非人灵长类动物的 BACE2 活性

Tschirner Sarah K, Zuchero Y Joy Yu, Getz Jennifer A, Müller Stephan A, Nalbach Karsten, Kennedy Matthew E, Lewcock Joseph W, Lichtenthaler Stefan F

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model

在早期发育过程中,血脑屏障处转铁蛋白受体介导的转运水平升高,并在衰老过程中以及阿尔茨海默病小鼠模型中维持稳定。

Vanessa O Torres ,Michelle E Pizzo ,Darren Chan ,Jason C Dugas ,David Huynh ,David Joy ,Eric K Liang ,Lily Sarrafha ,Isabel Becerra ,Roni Chau ,Kylie S Chew ,Johann Chow ,Claire B Discenza ,Timothy K Earr ,Laura Furaso ,Nathalie Khoury ,Kendra J Lechtenberg ,Amy W Leung ,Hoang N Nguyen ,Emmanuel S Ojo ,Elysia Roche ,Matthew J Simon ,Hilda Solanoy ,Mabel Tong ,Raymond K Tong ,Kirk Henne ,Joseph W Lewcock ,Ryan J Watts ,Meredith E Calvert ,Robert G Thorne ,Y Joy Yu Zuchero

Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants

在雅芳父母与儿童纵向研究(ALSPAC)参与者中,混合型B细胞和T细胞免疫与严重急性呼吸综合征冠状病毒2疫苗接种后预防突破性感染相关

Baum, Holly E; Santopaolo, Marianna; Francis, Ore; Milodowski, Emily J; Entwistle, Katrina; Oliver, Elizabeth; Hitchings, Benjamin; Diamond, Divya; Thomas, Amy C; Mitchell, Ruth E; Kibble, Milla; Gupta, Kapil; Di Bartolo, Natalie; Klenerman, Paul; Brown, Anthony; Morales-Aza, Begonia; Oliver, Jennifer; Berger, Imre; Toye, Ash M; Finn, Adam; Goenka, Anu; Davidson, Andrew D; Ring, Susan; Molloy, Lynn; Lewcock, Melanie; Northstone, Kate; Roth, Firona; Timpson, Nicholas J; Wooldridge, Linda; Halliday, Alice; Rivino, Laura